2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)-

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2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)- Suppliers list
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2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)- manufacturers

  • AM-8123
  • AM-8123 pictures
  • $293.00
  • 2026-07-27
  • CAS:2049973-02-4
  • Purity: 99.76%
  • Supply Ability: 10g
2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)- Basic information
Product Name:2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)-
Synonyms:2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)-;AM-8123
CAS:2049973-02-4
MF:C27H33N7O5S
MW:567.67
EINECS:
Product Categories:
Mol File:2049973-02-4.mol
2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)- Structure
2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)- Chemical Properties
Boiling point 754.1±70.0 °C(Predicted)
density 1.33±0.1 g/cm3(Predicted)
pka4.07±0.10(Predicted)
Safety Information
MSDS Information
2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)- Usage And Synthesis
UsesAM-8123 is an orally active and potent APJ agonist. AM-8123 inhibits Forskolin-stimulated cAMP production and promotes Gα protein activation. AM-8123 can be used for the research of cardiovascular disease[1].
in vivo

AM-8123 (100 mg/kg; p.o.) results in sustained improvement in systolic function and decreases both EDV and ESV as measured by echocardiography but not by the invasive pressure-volume conductance catheter at study termination[1].
AM-8123 (0.035, 0.09, 0.9, and 9 mg/kg; i.v.) improves cardiovascular function[1].
AM-8123 exhibits appreciably greater oral bioavailability in rats and dogs relative to pyr-apelin-13. AM-8123 infusion results in an increase in EF, SV, and dP/dt max at submicromolar unbound plasma concentrations with minimal change in HR, indicating that acute infusion of AM-8123 is associated with an improvement in several markers of cardiac function. AM-8123 is a more potent mediator of both ERK and AKT phosphorylation relative to pyr-apelin-13[1].

Animal Model:Lewis rats (2~3 months old)[1]
Dosage:100 mg/kg
Administration:P.o.
Result:Resulted in sustained improvement in systolic function.
Decreased both EDV and ESV as measured by echocardiography but not by the invasive pressure-volume conductance catheter at study termination.
Animal Model:Rats[1]
Dosage:0.035, 0.09, 0.9, and 9 mg/kg
Administration:I.v.
Result:Improved cardiovascular function.
References[1] Ason B, et al. Cardiovascular response to small-molecule APJ activation. JCI Insight. 2020;5(8):e132898. Published 2020 Apr 23. doi:10.1172/jci.insight.132898
2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)- Preparation Products And Raw materials
Tag:2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)-(2049973-02-4) Related Product Information
(2R,3S)-Azelaprag APJ receptor agonist 8 2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)- Azelaprag Apelin-13 TFA (Ala13)-Apelin-13 TFA