TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID
- CAS No.
- 3685-25-4
- Chemical Name:
- TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID
- Synonyms
- 4-azanylcyclohexane-1-carboxylic acid;4α-Amino-1β-cyclohexanecarboxylic acid;(1α)-4β-Aminocyclohexanecarboxylic acid;TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID;trans-4-Aminocyclohexanecarboxylic ccid;trans-4-Aminocyclohexyl carboxylic acid;trans-4-AminocyclohexanecarboxylicAcid>trans-4-Aminocyclohexane-1-carboxylic acid;Cyclohexanecarboxylic acid, 4-aMino-, trans-;trans-4-Aminocyclohexanecarboxylic Acid
- CBNumber:
- CB9104974
- Molecular Formula:
- C7H13NO2
- Molecular Weight:
- 143.18
- MDL Number:
- MFCD00209953
- MOL File:
- 3685-25-4.mol
- MSDS File:
- SDS
| Melting point | 495 °C |
|---|---|
| Boiling point | 56-58 °C(Press: 0.08 Torr) |
| Density | 1.133±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| Water Solubility | Soluble in water |
| form | powder to crystal |
| pka | 4.46±0.10(Predicted) |
| color | White to Almost white |
| InChI | InChI=1S/C7H13NO2/c8-6-3-1-5(2-4-6)7(9)10/h5-6H,1-4,8H2,(H,9,10)/t5-,6- |
| InChIKey | DRNGLYHKYPNTEA-IZLXSQMJSA-N |
| SMILES | [C@@H]1(C(O)=O)CC[C@@H](N)CC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| Safety Statements | 24/25 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29159000 | |||||||||
| NFPA 704 |
|
TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A1656 | trans-4-Aminocyclohexanecarboxylic Acid >98.0%(GC)(T) | 3685-25-4 | 1g | $52 | 2026-04-30 | Buy |
| TCI Chemical | A1656 | trans-4-Aminocyclohexanecarboxylic Acid >98.0%(GC)(T) | 3685-25-4 | 5g | $170 | 2026-04-30 | Buy |
| AstaTech | 51511 | TRANS-4-AMINO-CYCLOHEXANECARBOXYLIC ACID 97% | 3685-25-4 | 1G | $19 | 2026-04-30 | Buy |
| AstaTech | 51511 | TRANS-4-AMINO-CYCLOHEXANECARBOXYLIC ACID 97% | 3685-25-4 | 5G | $70 | 2026-04-30 | Buy |
| AstaTech | 51511 | TRANS-4-AMINO-CYCLOHEXANECARBOXYLIC ACID 97% | 3685-25-4 | 25G | $240 | 2026-04-30 | Buy |
TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID Chemical Properties,Uses,Production
Uses
The trans-4-Aminocyclohexanecarboxylic acid derivative is a useful building block for the synthesis of a variety of pharmacologically active compounds such as glimepiride (L-370518).
Synthesis
150-13-0
1776-53-0
3685-23-2
The general procedure for the synthesis of 4-aminocyclohexanecarboxylic acid and cis-4-aminocyclohexanecarboxylic acid from p-aminobenzoic acid is as follows: p-aminobenzoic acid (10.0 g, 0.07 mol, 1 equiv.), 5% Ru/C catalyst (2.50 g), and 10% NaOH solution (100.0 mL) were added in an autoclave. The mixture was subjected to 100 bar hydrogen pressure and the reaction was stirred in a 15 bar hydrogen atmosphere. After 20 h of reaction, the progress of the reaction was monitored by thin layer chromatography (TLC) with DCM/MeOH/NH3 (5:5:1, v/v/v) as the unfolding agent and ninhydrin as the color developer to confirm the complete consumption of the starting material. Nuclear magnetic resonance (NMR) analysis showed that the reaction was fully converted and the ratio of cis to trans product was 1:4.6. The reaction was terminated.
References
[1] European Journal of Medicinal Chemistry, 2001, vol. 36, # 3, p. 265 - 286
[2] Biochemische Zeitschrift, 1933, vol. 262, p. 462
[3] Journal of the American Chemical Society, 1938, vol. 60, p. 2341,2343
[4] Chemische Berichte, 1942, vol. 75, p. 425,428
[5] Chemische Berichte, 1943, vol. 76, p. 1019,1023
TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Advanced Technology Co., Ltd. | 010-69729398 18612521532 | sale@process-chem.com | China | 173 | 55 |
| TaiChem Taizhou Limited | 052386810091 | zcwy9518@yeah.net | China | 3917 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
View Lastest Price from TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 4-Aminocyclohexanecarboxylic acid
3685-25-4
|
$3.00-9.00 | 99% | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |||
 |
2025-04-04 | trans-4-Aminocyclohexane carboxylic acid
3685-25-4
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2024-07-20 | TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID
3685-25-4
|
$1.00 | 1Kg | 98% | 20T | Shaanxi Dideu Medichem Co. Ltd |
-
- 4-Aminocyclohexanecarboxylic acid
3685-25-4
- $3.00-9.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- trans-4-Aminocyclohexane carboxylic acid
3685-25-4
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID
3685-25-4
- $1.00
- 98%
- Shaanxi Dideu Medichem Co. Ltd
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