ChemicalBook >> CAS DataBase List >>trans-4-Dimethylaminocrotonic acid hydrochloride
trans-4-Dimethylaminocrotonic acid hydrochloride
- CAS No.
- 848133-35-7
- Chemical Name:
- trans-4-Dimethylaminocrotonic acid hydrochloride
- Synonyms
- (E)-4-(dimethylamino)but-2-enoic acid hydrochloride;(e)-4-(dimethylamino)-2-butenoic acid hydrochloride;THRX-196194;Afatinib intermediate E;trans-4-Dimethylaminocrotonic;(E)-4-(Dimethylamino)-2-buteno;TRANS-4-DIMETHYLAMINOCROTONIC ACID HCL;(E)-4-(DIMETHYLAMINO)BUT-2-ENOIC ACID HCL;4-DiMethylaMino-But-2-Enoic Acid Hcl Salt;(2E)-4-(Dimethylamino)but-2-enoic acid HCl
- CBNumber:
- CB8854829
- Molecular Formula:
- C6H12ClNO2
- Molecular Weight:
- 165.62
- MDL Number:
- MFCD03695466
- MOL File:
- 848133-35-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-05-28 03:33:46
| Melting point | 162 °C |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1S/C6H11NO2.ClH/c1-7(2)5-3-4-6(8)9;/h3-4H,5H2,1-2H3,(H,8,9);1H/b4-3+; |
| InChIKey | UUHNQHFOIVLAQX-BJILWQEISA-N |
| SMILES | C(/CN(C)C)=C\C(=O)O.Cl |
| CAS DataBase Reference | 848133-35-7(CAS DataBase Reference) |
| FDA UNII | ZRA8B68TND |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| HS Code | 2922498590 | |||||||||
| NFPA 704 |
|
trans-4-Dimethylaminocrotonic acid hydrochloride price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D5625 | (E)-4-(Dimethylamino)-2-butenoic Acid Hydrochloride | 848133-35-7 | 1G | $31 | 2026-04-30 | Buy |
| TCI Chemical | D5625 | (E)-4-(Dimethylamino)-2-butenoic Acid Hydrochloride | 848133-35-7 | 5G | $114 | 2026-04-30 | Buy |
| TRC | TRC-D446630-1G | trans 4-Dimethylaminocrotonic Acid Hydrochloride | 848133-35-7 | 1g | $142 | 2026-06-03 | Buy |
| Usbiological | 009646 | trans 4-Dimethylaminocrotonic Acid Hydrochloride | 848133-35-7 | 250mg | $418 | 2026-06-03 | Buy |
| Biosynth | FD22343 | trans 4-Dimethylaminocrotonic acid HCl | 848133-35-7 | 100g | $389 | 2026-06-04 | Buy |
trans-4-Dimethylaminocrotonic acid hydrochloride Chemical Properties, Uses, Production
Description
trans-4-Dimethylaminocrotonic acid hydrochloride is a very important pharmaceutical intermediate and is an essential part of the structure of the anti-tumour drugs afatinib and neratinib. It is also an important organic synthesis reagent for the preparation of novel pyrazole derivatives and 6-heterocycloalkyl quinazoline derivatives.
Chemical Properties
White Solid
Uses
trans 4-Dimethylaminocrotonic acid HCl is a reagent used in the preparation of tyrosine kinase inhibiting antitumor agents.
Synthesis
trans-4-Dimethylaminocrotonic acid hydrochloride is synthesised using (E)-4-(dimethylamino)-2-butenoic acid methyl ester as a raw material by adding reagents such as water, sodium hydroxide, methanol, and hydrogen chloride through a chemical reaction.
trans-4-Dimethylaminocrotonic acid hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global Suppliers ( 389)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan XuanDe Chemical Co., Ltd. | 0531-88803958 19862127196 | zhangxu@shiningpharm.com | China | 201 | 58 |
| Sichuan Hainuowei Technology Co. Ltd. | 13708085536 13708085536 | hanovichem@163.com | China | 3268 | 56 |
| Established by Hangzhou Boman Biochem Tech Co., Ltd | 13588048971 | sales@bomanbiochem.com | China | 491 | 58 |
| Mianyang Vandino Pharmaceutical Technology Co., Ltd. | 15681201579 15861805752 | 1755695756@qq.com | China | 291 | 58 |
| TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD. | 022-60189726 18812034280 | 188120342808@163.com | China | 143 | 61 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
View Latest Price from trans-4-Dimethylaminocrotonic acid hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | trans-4-Dimethylaminocrotonic acid hydrochloride
848133-35-7
|
1g | 99% | 100mt/year | Jinan Finer Chemical Co., Ltd | ||
 |
2026-09-02 | trans-4-Dimethylaminocrotonic acid hydrochloride
848133-35-7
|
$5.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | trans-4-Dimethylaminocrotonic acid hydrochloride
848133-35-7
|
$1.10 | 1g | 99.0% Min | 100 Tons | Dideu Industries Group Limited |
-
- trans-4-Dimethylaminocrotonic acid hydrochloride
848133-35-7
- $0.00
- 99%
- Jinan Finer Chemical Co., Ltd
-
- trans-4-Dimethylaminocrotonic acid hydrochloride
848133-35-7
- $5.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- trans-4-Dimethylaminocrotonic acid hydrochloride
848133-35-7
- $1.10
- 99.0% Min
- Dideu Industries Group Limited
848133-35-7 (trans-4-Dimethylaminocrotonic acid hydrochloride) Related Search:
Isopropyl 3-aminocrotonate
L-Lysine hydrochloride
Crotonic acid
Topotecan hydrochloride
BOC-1,4-TRANS-ACHC-OH
Trans-4-(Maleimidomethyl)cyclohexanecarboxylic Acid
trans-1-Chloro-3,3,3-trifluoroprop-1-ene
N,N-Dimethylformamide
trans-Ethyl 4-aminocyclohexanecarboxylate hydrochloride
trans-3-fluoro-3-methylcyclobutane-1-carboxylic acid
1of4
2E)-4-(Dimethylamino)-2-butenoic acid hydrochloride
Afatinib int-2 Trans-4-Dimethylaminocrotonic acid hydrochloride
2-Butenoic acid, 4-(dimethylamino)-, (2E)-, hydrochloride
trans-4-Dimethylaminocrotonic acid hydrochloride, >=97%
trans-4-Dimethylaminocrotonic
trans-4-dimethylaminocrotonic acid hydrochloride salt
2-Butenoic acid,4-(dimethylamino)-, hydrochloride (1:1), (2E)-
trans-4-Dimethylaminocrotonic acid hydrochloride(848133-35-7)
(E)-4-(DIMETHYLAMINO)BUT-2-ENOIC ACID HCL
(e)-4-(dimethylamino)-2-butenoic acid hydrochloride
4-DiMethylaMino-But-2-Enoic Acid Hcl Salt
trans-4-Dimethylaminocrotonic acid hydrochloride
TRANS-4-DIMETHYLAMINOCROTONIC ACID HCL
2-BUTENOIC ACID, 4-(DIMETHYLAMINO)-, HYDROCHLORIDE
Afatinib intermediate E
(2E)-4-(diMethylaMino)but-2-enoic acid hydrochloride
trans-4-(DiMethylaMino)-2-butenoic Acid Hydrochloride
trans-4-Dimethylaminocrotonic acid hydrochloride (E)-4-(Dimethylamino)-2-butenoic acid hydrochloride
(2E)-4-(dimethylamino)but-2-enoic acid hydrochloride, trans
2-Butenoic acid, 4-(dimethylamino)-, hydrochloride (1:1)
(2E)-4-(Dimethylamino)but-2-enoic acid?hydrochloride (1:1)
(E)-4-Dimethylaminocrotonic Acid Hydrochloride
trans-4-Dimethylaminocrotonic acid hydrochloride ISO 9001：2015 REACH
THRX-196194
(E)-4-(Dimethylamino)-2-buteno
(2E)-4-(dimethylamino)-2-Butenoic acid hydrochloride (1:1)
(2E)-4-(Dimethylamino)but-2-enoic acid HCl
trans-4-Dimethylaminocrotonic acid hydrochloride，(E)-4-(Dimethylamino)But-2-Enoic Acid Hydrochloride
848133-35-7Trans-4-dimethylaminocrotonicacidhydrochloride
trans-4-Dimethylaminocrotonic acid HCl 98%
trans-4-Dimethylaminocrotonic acid hydrochloride
Afatinib Int
(E)-4-(dimethylamino)but-2-enoic acid hydrochloride
trans-4-(Dimethylamino)but-2-enoic acid hydrochloride
848133-35-7
Others chemical reagents
Amines
Intermediates & Fine Chemicals
Pharmaceuticals
848133-35-7
