2,3'-Bipyridine, 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-, hydrochloride (1:1)

2,3'-Bipyridine, 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-, hydrochloride (1:1) structure

CAS No.: 202409-40-3

Chemical Name:: 2,3'-Bipyridine, 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-, hydrochloride (1:1)

Synonyms: Etoricoxib HCl;L791456 hydrochloride;L-791456 hydrochloride;L 791456 hydrochloride;Etoricoxib hydrochloride;L-791456 monohydrochloride salt;2,3'-Bipyridine, 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-, hydrochloride (1:1)

CBNumber:: CB910662525

Molecular Formula:: C18H16Cl2N2O2S

Molecular Weight:: 395.3

MDL Number:

MOL File:: 202409-40-3.mol

MSDS File:: SDS

Last updated:2025-04-18 09:52:59

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2,3'-Bipyridine, 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-, hydrochloride (1:1) Properties

FDA UNII	138Y28RY5E

2,3'-Bipyridine, 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-, hydrochloride (1:1) Chemical Properties, Uses, Production

Uses

Etoricoxib hydrochloride (MK-0663 hydrochloride) is a synthetic nonsteroidal anti-inflammatory drug with cyclooxygenase-2 inhibitory activity. Etoricoxib hydrochloride can inhibit the conversion of arachidonic acid to prostaglandins, thereby reducing inflammation and pain. Etoricoxib hydrochloride is used to inhibit osteoarthritis and has anti-inflammatory and bone remodeling effects. The formulation of etoricoxib hydrochloride is prepared by emulsion solvent evaporation technology and exhibits good cell compatibility and enhanced alkaline phosphatase activity[1].

References

[1] Riendeau D, et al.Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2. J Pharmacol Exp Ther. 2001 Feb;296(2):558-66. PMID:11160644
[2] Etoricoxib-loaded bio-adhesive hybridized polylactic acid-based nanoparticles as an intra-articular injection for the treatment of osteoarthritis DOI:10.1016/j.ijpharm.2020.119081
[3] Kunak CS, et al. The Effect of Etoricoxib on Hepatic Ischemia-Reperfusion Injury in Rats. Oxid Med Cell Longev. 2015;2015:598162. DOI:10.1155/2015/598162
[4] Tanwar L, et al. Anti-proliferative and apoptotic effects of etoricoxib, a selective COX-2 inhibitor, on 1,2-dimethylhydrazine dihydrochloride-induced colon carcinogenesis. Asian Pac J Cancer Prev. 2010;11(5):1329-33. PMID:21198287

2,3'-Bipyridine, 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-, hydrochloride (1:1) Preparation Products And Raw materials

Raw materials

Preparation Products

2,3'-Bipyridine, 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-, hydrochloride (1:1) Suppliers

Global Suppliers ( 2)

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58

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2,3'-Bipyridine, 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-, hydrochloride (1:1) Etoricoxib HCl Etoricoxib hydrochloride L 791456 hydrochloride L791456 hydrochloride L-791456 hydrochloride L-791456 monohydrochloride salt 202409-40-3