2-Chloro-6-(trifluoromethyl)nicotinonitrile
- CAS No.
- 386704-06-9
- Chemical Name:
- 2-Chloro-6-(trifluoromethyl)nicotinonitrile
- Synonyms
- 2-Chloro-6-trifuoromethyl-nico;2-Chloro-6-(trifluoromethyl)nicot;hloro-6-(trifluoromethyl)nicotinonitrile;2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINITRILE;2-Chloro-6-(trifluoromethyl)nicotinonitrile;2-chloro-6-(trifluoromethyl)-3-pyridinecarbonitrile;3-Pyridinecarbonitrile, 2-chloro-6-(trifluoromethyl)-;2-Chloro-6-(trifluoromethyl)pyridine-3-carbonitrile, 2-Chloro-3-cyano-6-(trifluoromethyl)pyridine
- CBNumber:
- CB91096456
- Molecular Formula:
- C7H2ClF3N2
- Molecular Weight:
- 206.55
- MDL Number:
- MFCD01862660
- MOL File:
- 386704-06-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933399990 |
2-Chloro-6-(trifluoromethyl)nicotinonitrile price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC5448 | 2-Chloro-6-(trifluoromethyl)nicotinonitrile 98% | 386704-06-9 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC5448 | 2-Chloro-6-(trifluoromethyl)nicotinonitrile 98% | 386704-06-9 | 5g | $55 | 2026-06-04 | Buy |
| Apolloscientific | PC5448 | 2-Chloro-6-(trifluoromethyl)nicotinonitrile 98% | 386704-06-9 | 25g | $256 | 2026-06-04 | Buy |
| Synthonix | C38965 | 2-Chloro-6-(trifluoromethyl)nicotinonitrile 95+% | 386704-06-9 | 1g | $51 | 2026-05-06 | Buy |
| Synthonix | C38965 | 2-Chloro-6-(trifluoromethyl)nicotinonitrile 95+% | 386704-06-9 | 5g | $60 | 2026-05-06 | Buy |
2-Chloro-6-(trifluoromethyl)nicotinonitrile Chemical Properties, Uses, Production
Synthesis
116548-04-0
386704-06-9
Step 3: Preheated 2-hydroxy-6-trifluoromethylnicotinonitrile (45 g, 0.24 mol) was mixed with phosphoryl chloride (90 mL) and phosphorus pentachloride (74.6 g, 0.359 mol) was slowly added. Violent foaming was observed on initial addition. After addition, the reaction mixture was gently refluxed for 22 hours. Complete conversion of the feedstock to 2-chloro-6-trifluoromethylnicotinonitrile was confirmed by TLC (detected as a small amount of the reaction mixture quenched with saturated sodium bicarbonate solution). Subsequently, the reaction mixture was cooled to 50-55 °C and the excess phosphoryl chloride was removed by distillation under reduced pressure. The residue was poured into crushed ice (~100 g) and neutralized with saturated sodium bicarbonate solution. The aqueous phase was extracted with ethyl acetate (3 x 200 mL), the organic layers were combined and washed sequentially with water (200 mL) and brine (200 mL) and dried over anhydrous magnesium sulfate. The organic solvent was concentrated under reduced pressure to obtain a brown liquid crude product, which was purified by column chromatography (eluent: 10% ethyl acetate in hexane solution) to obtain 2-chloro-6-trifluoromethylnicotinonitrile (36g, yield 73%) as a light brown liquid.
References
[1] Patent: US2013/79373, 2013, A1. Location in patent: Paragraph 0265; 0268
[2] Patent: WO2013/45452, 2013, A1. Location in patent: Page/Page column 40
2-Chloro-6-(trifluoromethyl)nicotinonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Changzhou Huanling Chemical Co., Ltd. | 89803005 18206112582 | info@huanlingchem.com | China | 983 | 68 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Nan Jing Dirise Chemcial Co.,LTD | 025-52161033 15312098939 | 2432674894@qq.com | China | 585 | 64 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6742 | 52 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Sphinx Scientific Laboratory (Tianjin) Co., Ltd. | 022-66211289-843 13672102692 | contact@sphinxpharm.com | China | 361 | 62 |
View Latest Price from 2-Chloro-6-(trifluoromethyl)nicotinonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINONITRILE
386704-06-9
|
$1.50-36.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2021-07-13 | 2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINONITRILE
386704-06-9
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINONITRILE
386704-06-9
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINONITRILE
386704-06-9
- $1.50-36.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINONITRILE
386704-06-9
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINONITRILE
386704-06-9
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
