2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINONITRILE
- CAS No.
- 386704-06-9
- Chemical Name:
- 2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINONITRILE
- Synonyms
- 2-Chloro-6-trifuoromethyl-nico;2-Chloro-6-(trifluoromethyl)nicot;hloro-6-(trifluoromethyl)nicotinonitrile;2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINITRILE;2-Chloro-6-(trifluoromethyl)nicotinonitrile;2-chloro-6-(trifluoromethyl)-3-pyridinecarbonitrile;3-Pyridinecarbonitrile, 2-chloro-6-(trifluoromethyl)-;2-Chloro-6-(trifluoromethyl)pyridine-3-carbonitrile, 2-Chloro-3-cyano-6-(trifluoromethyl)pyridine
- CBNumber:
- CB91096456
- Molecular Formula:
- C7H2ClF3N2
- Molecular Weight:
- 206.55
- MDL Number:
- MFCD01862660
- MOL File:
- 386704-06-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Chloro-6-(trifluoromethyl)nicotinonitrile 98% | PC5448 | 1g | $21 |
| 2-Chloro-6-(trifluoromethyl)nicotinonitrile 98% | PC5448 | 5g | $55 |
| 2-Chloro-6-(trifluoromethyl)nicotinonitrile 98% | PC5448 | 25g | $256 |
| 2-Chloro-6-(trifluoromethyl)nicotinonitrile 98% | PC5448 | 1g | $21 |
| 2-Chloro-6-(trifluoromethyl)nicotinonitrile 98% | PC5448 | 5g | $55 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933399990 |
2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINONITRILE price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC5448 | 2-Chloro-6-(trifluoromethyl)nicotinonitrile 98% | 386704-06-9 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC5448 | 2-Chloro-6-(trifluoromethyl)nicotinonitrile 98% | 386704-06-9 | 5g | $55 | 2026-06-04 | Buy |
| Apolloscientific | PC5448 | 2-Chloro-6-(trifluoromethyl)nicotinonitrile 98% | 386704-06-9 | 25g | $256 | 2026-06-04 | Buy |
| Apolloscientific | PC5448 | 2-Chloro-6-(trifluoromethyl)nicotinonitrile 98% | 386704-06-9 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC5448 | 2-Chloro-6-(trifluoromethyl)nicotinonitrile 98% | 386704-06-9 | 5g | $55 | 2026-06-04 | Buy |
2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINONITRILE Chemical Properties,Uses,Production
Synthesis
116548-04-0
386704-06-9
Step 3: Preheated 2-hydroxy-6-trifluoromethylnicotinonitrile (45 g, 0.24 mol) was mixed with phosphoryl chloride (90 mL) and phosphorus pentachloride (74.6 g, 0.359 mol) was slowly added. Violent foaming was observed on initial addition. After addition, the reaction mixture was gently refluxed for 22 hours. Complete conversion of the feedstock to 2-chloro-6-trifluoromethylnicotinonitrile was confirmed by TLC (detected as a small amount of the reaction mixture quenched with saturated sodium bicarbonate solution). Subsequently, the reaction mixture was cooled to 50-55 °C and the excess phosphoryl chloride was removed by distillation under reduced pressure. The residue was poured into crushed ice (~100 g) and neutralized with saturated sodium bicarbonate solution. The aqueous phase was extracted with ethyl acetate (3 x 200 mL), the organic layers were combined and washed sequentially with water (200 mL) and brine (200 mL) and dried over anhydrous magnesium sulfate. The organic solvent was concentrated under reduced pressure to obtain a brown liquid crude product, which was purified by column chromatography (eluent: 10% ethyl acetate in hexane solution) to obtain 2-chloro-6-trifluoromethylnicotinonitrile (36g, yield 73%) as a light brown liquid.
References
[1] Patent: US2013/79373, 2013, A1. Location in patent: Paragraph 0265; 0268
[2] Patent: WO2013/45452, 2013, A1. Location in patent: Page/Page column 40
2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20121 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Baoji Guokang Healthchem Co., Ltd. | +86-0917-3909592 +86-13892490616 | gksales1@gk-bio.com | China | 9056 | 58 |
View Lastest Price from 2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINONITRILE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-09 | 2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINONITRILE
386704-06-9
|
$1.50-36.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2021-07-13 | 2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINONITRILE
386704-06-9
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINONITRILE
386704-06-9
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINONITRILE
386704-06-9
- $1.50-36.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINONITRILE
386704-06-9
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 2-CHLORO-6-(TRIFLUOROMETHYL)NICOTINONITRILE
386704-06-9
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
