1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine
- CAS No.
- 141699-58-3
- Chemical Name:
- 1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine
- Synonyms
- 1-Boc-3-(mesyloxy)azetidine;N-Boc-3-methanesulfonyloxyazetidine;1-Boc-3-methanesulfonyloxy-azetidine;N-Boc 3-(Methylsulfonyloxy)azetidine;1-N-BOC-3-METHANESULFONYLOXYAZETIDINE;1-(tert-Butoxycarbonyl)-3-(mesyloxy)azetidine;tert-butyl 3-methylsulfonyloxyazetidine-1-carboxylate;1-(tert-butoxycarbonyl)azetidine-3-yl-methanesulfonate;tert-Butyl 3-[(methylsulfonyl)oxy]azetane-1-carboxylate;1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine
- CBNumber:
- CB91116921
- Molecular Formula:
- C9H17NO5S
- Molecular Weight:
- 251.3
- MDL Number:
- MFCD05664832
- MOL File:
- 141699-58-3.mol
| Product description | Number | Pack Size | Price |
| tert-Butyl 3-[(methylsulfonyl)oxy]-1-azetanecarboxylate Aldrich | SYX00004 | 1g | $30.7 |
| tert-Butyl 3-[(Methylsulfonyl)oxy]azetidine-1-carboxylate >98.0%(GC) | B5801 | 5g | $40 |
| tert-Butyl 3-[(Methylsulfonyl)oxy]azetidine-1-carboxylate >98.0%(GC) | B5801 | 25g | $156 |
| tert-Butyl3-(Methanesulfonyloxy)azetidine-1-carboxylate | B423283 | 100mg | $60 |
| tert-Butyl 3-[(methylsulfonyl)oxy]azetidine-1-carboxylate | FB136866 | 500mg | $75 |
| More product size | |||
| Melting point | 69 °C |
|---|---|
| Boiling point | 378.5±31.0 °C(Predicted) |
| Density | 1.28±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | -4.18±0.40(Predicted) |
| form | powder to crystal |
| color | White to Light yellow |
| InChI | InChI=1S/C9H17NO5S/c1-9(2,3)14-8(11)10-5-7(6-10)15-16(4,12)13/h7H,5-6H2,1-4H3 |
| InChIKey | XXBDTKYKFFIAEY-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CC(OS(C)(=O)=O)C1 |
| UNSPSC Code | 12352200 |
1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SYX00004 | tert-Butyl 3-[(methylsulfonyl)oxy]-1-azetanecarboxylate Aldrich | 141699-58-3 | 1g | $30.7 | 2025-07-31 | Buy |
| TCI Chemical | B5801 | tert-Butyl 3-[(Methylsulfonyl)oxy]azetidine-1-carboxylate >98.0%(GC) | 141699-58-3 | 5g | $40 | 2025-07-31 | Buy |
| TCI Chemical | B5801 | tert-Butyl 3-[(Methylsulfonyl)oxy]azetidine-1-carboxylate >98.0%(GC) | 141699-58-3 | 25g | $156 | 2025-07-31 | Buy |
| TRC | B423283 | tert-Butyl3-(Methanesulfonyloxy)azetidine-1-carboxylate | 141699-58-3 | 100mg | $60 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB136866 | tert-Butyl 3-[(methylsulfonyl)oxy]azetidine-1-carboxylate | 141699-58-3 | 500mg | $75 | 2021-12-16 | Buy |
1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine Chemical Properties,Uses,Production
Synthesis
124-63-0
141699-55-0
141699-58-3
Preparation of Example 26-2: tert-butyl 3-((methylsulfonyl)oxy)azetidine-1-carboxylate Under a nitrogen atmosphere, methanesulfonyl chloride (2.57 mL, 33.3 mmol) and triethylamine (11.6 mL, 83.1 mmol) were sequentially added to a solution of tetrahydrofuran (100 mL) containing N-Boc-3-hydroxyazetidine (4.8 g, 27.7 mmol). The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, saturated aqueous sodium bicarbonate solution was added to the reaction solution and the mixture was diluted with ethyl acetate. The organic layer was separated, washed with saturated brine and subsequently dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under vacuum. The residue was purified by silica gel column chromatography (eluent ratio: n-heptane/ethyl acetate = 9:1 to 1:1) to quantitatively obtain N-Boc-3-methylsulfonyloxyazetidine. 1H-NMR (CDCl3) δ (ppm): 1.45 (9H, s), 3.07 (3H, s), 4.03-4.18 (2H, m), 4.22-4.36 (2H, m), 5.12-5.27 (1H, m).
References
[1] Patent: US2014/235614, 2014, A1. Location in patent: Paragraph 0570; 0571; 0572
[2] Patent: EP1340757, 2003, A1
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 18, p. 7731 - 7757
[4] Patent: WO2018/102419, 2018, A1. Location in patent: Paragraph 0344; 0345; 0346; 0347
[5] Patent: US2012/10182, 2012, A1. Location in patent: Page/Page column 40
1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29850 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2176 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
View Lastest Price from 1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-07-06 | 1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine
141699-58-3
|
US $1.00 / KG | 1KG | 95% | 500KG | Career Henan Chemical Co |
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- 1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine
141699-58-3
- US $1.00 / KG
- 95%
- Career Henan Chemical Co
