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BUCLIZINE

BUCLIZINE Structure
BUCLIZINE structure
CAS No.
82-95-1
Chemical Name:
BUCLIZINE
Synonyms
ah2526;AH 2526;Postafen;Bucladin;Buclifen;Buclozin;BUCLIZINE;Hitabutyzyne;Histabutyzine;Histabutizine
CBNumber:
CB9111794
Molecular Formula:
C28H33ClN2
Molecular Weight:
433.03
MDL Number:
MFCD00242701
MOL File:
82-95-1.mol
MSDS File:
SDS
Last updated:2026-05-28 04:54:14
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BUCLIZINE Properties

Boiling point bp0.001 217-220°
Density 0.9970 (rough estimate)
refractive index 1.5940 (estimate)
pka 6.84±0.10(Predicted)
EWG's Food Scores 1
FDA UNII 0C94V6X681
ATC code R06AE01,R06AE51

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P261-P280-P305+P351+P338-P304+P340

BUCLIZINE price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
aablocks AA00G4AK Buclizine 95% 82-95-1 1g $52 2026-05-28 Buy
aablocks AA00G4AK Buclizine 95% 82-95-1 5g $185 2026-05-28 Buy
aablocks AA00G4AK Buclizine 95% 82-95-1 10g $318 2026-05-28 Buy
aablocks AA00G4AK Buclizine 95% 82-95-1 25g $718 2026-05-28 Buy
Crysdot CD11050241 Buclizine 97% 82-95-1 1g $589 2026-05-26 Buy
Product number Packaging Price Buy
AA00G4AK 1g $52 Buy
AA00G4AK 5g $185 Buy
AA00G4AK 10g $318 Buy
AA00G4AK 25g $718 Buy
CD11050241 1g $589 Buy

BUCLIZINE Chemical Properties, Uses, Production

Chemical Properties

White powder crystal. Melting point 230-240°C (221-225°C). Insoluble in water, soluble in ethanol, chloroform, boiling point 217-220 ℃ (0.133 kPa). Its hydrochloride (C28H33CIN2-2HCI = 505.98) is also known as Anchimine, melting point 265-266 ℃.

Originator

Longifine,UCB

Uses

Buclizine is an antinauseant.

Definition

ChEBI: An N-alkylpiperazine carrying (4-chlorophenyl)(phenyl)methyl and 4-tert-butylbenzyl groups.

Manufacturing Process

1 mol 4-chlorobenzhydril chloride was heated in toluene to reflux with 1 mol ethyl ester of piperazine 1-carboxylic acid at about 150°C in a presence of an excess of triethyl amine. On cooling the triethyl amine hydrochloride was filtered off, a solvent was removed in vacuum and the residue [(4-chlorophenyl)- phenyl-methyl]piperazine carboxylic acid ethyl ester was boiled straight away with potassium hydroxide in ethanol for 48 hours. After removing ethanol in vacuum to dryness, the residue was dissolved in benzene and washed with water. The benzene solution was dried, benzene removed in vacuum. The residue was distilled to give 4-chlorobezhydryl-piperazine. It had given the desired 1-(p-tert-butylbenzyl)-4-(p-chloro-α-phenylbenzyl)- piperazine, buclizine, by a reaction with 4-tert-butylbenzyl chloride in the presence of any halogen hydrochloride acceptor (triethyl amine, sodium or potassium carbonate and so on). The obtained product had BP: 230°- 240°C/0.001 mm Hg.

brand name

Bucladin (Stuart).

Therapeutic Function

Antihistaminic, Antiallergic, Antinauseant, Tranquilizer, Appetite stimulant

Synthesis

Buclizine is mainly used in the prevention of motion sickness and in combination with analgesics for treatment of migraine.

BUCLIZINE synthesis

129-74-8
82-95-1
Synthesis of BUCLIZINE from Buclizine, dihydrochloride

BUCLIZINE Preparation Products And Raw materials

Raw materials

Paraformaldehyde tert-Butylbenzene 1-Benzylpiperazine Bromo(4-chlorophenyl)phenyl methane Aluminium chloride hexahydrate
4-Chlorobenzhydrylchloride Ethyl N-piperazinecarboxylate 4-tert-Butylbenzyl chloride 1-(4-Chlorobenzhydryl)piperazine 1-(4-tert-Butylbenzyl)piperazine
Buclizine, dihydrochloride 4-tert-Butylbenzyl alcohol 4-Chlorobenzaldehyde

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Preparation Products

BUCLIZINE Suppliers

Global Suppliers ( 66)
Supplier Tel Email Country ProdList Advantage
Syntechem Co.,Ltd info@syntechem.com China 12973 57
S.Z. PhyStandard Bio-Tech. Co., Ltd. 0755-83725681-603 China 4484 50
Beijing HuaMeiHuLiBiological Chemical 010-56205725 waley188@sohu.com China 12323 58
Cantotech Chemicals, Ltd. 86-0755-86635001 cantotech@126.com China 4554 55
Quality Control Solutions Ltd. 0755-66853366 13670046396 orders@qcsrm.com China 18188 56
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Wuhai Shuou Technology Co., Ltd. 17792809151;18872220797 2355916837@ycphar.com China 6120 55
MQ (shanghai) Pharmaceuticals Co., Ltd. 13761635123 sales@linyuepharm.com China 5731 55
Taian Jiaye Biotechnology Co.Ltd 15318151873;13127280945 285424065@qq.com China 9961 55
Wuhan Netcom Electronic Commerce Limited 18064670521 2355935187@ycphar.com China 4870 58
Supplier Advantage
Syntechem Co.,Ltd 57
S.Z. PhyStandard Bio-Tech. Co., Ltd. 50
Beijing HuaMeiHuLiBiological Chemical 58
Cantotech Chemicals, Ltd. 55
Quality Control Solutions Ltd. 56
Shanghai YuanYe Biotechnology Co., Ltd. 60
Wuhai Shuou Technology Co., Ltd. 55
MQ (shanghai) Pharmaceuticals Co., Ltd. 55
Taian Jiaye Biotechnology Co.Ltd 55
Wuhan Netcom Electronic Commerce Limited 58

View Latest Price from BUCLIZINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Buclizine pictures 2026-04-20 Buclizine
82-95-1
 $1520.00-2500.00 10g TargetMol Chemicals Inc.
  • Buclizine pictures
  • Buclizine
    82-95-1
  • $1520.00-2500.00
  • TargetMol Chemicals Inc.

82-95-1 (BUCLIZINE) Related Search:

Cetirizine dihydrochloride Cetirizine 1-(4-Methylbenzyl)piperazine Buclizine, dihydrochloride 1-(4-Chlorobenzyl)piperazine
BUCLIZINE CHLORCYCLIZINE Cyclizine 4-tert-Butylbenzylamine 1-(4-Chlorobenzhydryl)piperazine
1-Benzhydrylpiperazine 1-(4-tert-Butylbenzyl)piperazine BUCLIZINE HCL migraleve N-(4-Isopropylbenzyl)ethanamine
1-(4-Ethyl-benzyl)-piperazine Buclizine hydrochloride impurity standard Buclizine hydrochloride imp. A (BP): 1,4-bis(4-chlorobenzhydryl)piperazine

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Histabuticine Histabutizine Histabutyzine Hitabutyzyne Piperazine, 1-(p-tert-butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl)- Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]- piperazine,1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl) Postafen ah2526 Aphilan-R base aphilan-rbase Bucladin Buclifen 1-[4-(Chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]piperrazine AH 2526 1-(4-tert-Butylbenzyl)-4-[(4-chlorophenyl)(phenyl)methyl]piperazine 1-(p-tert-butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl)-piperazin 1-(p-tert-Butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl)piperazine Buclozin Buclizine diHCl BUCLIZINE 1-(4-tert-butylbenzyl)-4-(4-chlorobenzhydryl)piperazine Buclizinebase Buclizine (base and/or unspecified salts) 82-95-1 1129-74-8 C28H33ClN2