4'-Hydroxy-3'-nitroacetophenone
- CAS No.
- 6322-56-1
- Chemical Name:
- 4'-Hydroxy-3'-nitroacetophenone
- Synonyms
- 1-(4-hydroxy-3-nitrophenyl)ethan-1-one;4-HYDROXY-3-NITROACETOPHENONE;NSC 32113;2-Nitro-4-acetylphenol;Formoterol Impurity 68;4-ACETYL-2-NITRO-PHENOL;Acetophenone Impurity 8;-Hydroxy-3-nitroacetophenone;3-NITRO-4-HYDROXY ACETOPHENONE;3'-NITRO-4'-HYDROXYACETOPHENONE
- CBNumber:
- CB9114043
- Molecular Formula:
- C8H7NO4
- Molecular Weight:
- 181.15
- MDL Number:
- MFCD00017002
- MOL File:
- 6322-56-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 132-135 °C(lit.) |
|---|---|
| Boiling point | 314.24°C (rough estimate) |
| Density | 1.4283 (rough estimate) |
| refractive index | 1.5468 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Chloroform, Dichloromethane, DMSO, Ethyl Acetate |
| form | powder to crystal |
| pka | 5.18±0.14(Predicted) |
| color | Light yellow to Amber to Dark green |
| BRN | 1959078 |
| InChI | 1S/C8H7NO4/c1-5(10)6-2-3-8(11)7(4-6)9(12)13/h2-4,11H,1H3 |
| InChIKey | MMNKVWGVSHRIJL-UHFFFAOYSA-N |
| SMILES | CC(=O)c1ccc(O)c(c1)[N+]([O-])=O |
| CAS DataBase Reference | 6322-56-1(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Hydroxy-3-nitroacetophenone(6322-56-1) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39-36-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29147000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4'-Hydroxy-3'-nitroacetophenone price More Price(68)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 330256 | 4′-Hydroxy-3′-nitroacetophenone 98% | 6322-56-1 | 1g | $42.9 | 2023-01-07 | Buy |
| TCI Chemical | H0968 | 4'-Hydroxy-3'-nitroacetophenone >98.0%(GC) | 6322-56-1 | 5g | $27 | 2026-04-30 | Buy |
| AstaTech | 28657 | 4-ACETYL-2-NITRO-PHENOL 97% | 6322-56-1 | 25G | $23 | 2026-04-30 | Buy |
| AstaTech | 28657 | 4-ACETYL-2-NITRO-PHENOL 97% | 6322-56-1 | 100G | $53 | 2026-04-30 | Buy |
| Biosynth | FH24225 | 4'-Hydroxy-3'-nitroacetophenone | 6322-56-1 | 0.5kg | $150 | 2026-06-04 | Buy |
4'-Hydroxy-3'-nitroacetophenone Chemical Properties,Uses,Production
Chemical Properties
Yellow Solid
Uses
4’-Hydroxy-3’-nitroacetophenone, >95% (cas# 6322-56-1) is a compound useful in organic synthesis.
Uses
4′-Hydroxy-3′-nitroacetophenone may be used in chemical synthesis.
Preparation
Preparation by nitration of 4-hydroxyacetophenone.
Synthesis
99-93-4
6322-56-1
The general procedure for the synthesis of 4'-hydroxy-3'-nitroacetophenone from p-hydroxyacetophenone was as follows: phenol (94 mg, 1 mmol) was dissolved in 3 mL of glacial acetic acid in a 50 mL test tube. Solid Y(NO3)3-6H2O (383 mg, 1 mmol) was then added and the reaction mixture was shaken continuously for 10 min at room temperature. The reaction process was monitored by thin layer chromatography (TLC) in petroleum ether with 10% ethyl acetate. After completion of the reaction, 30 mL of ice-cold water was added to the reaction mixture and allowed to stand for 15 min. The solid product was collected by filtration and washed with distilled water. The resulting solid product was used for analysis without further purification. The experimental methods for synthesizing compounds 2a-2e are detailed in Supporting Information.
References
[1] Synthetic Communications, 1997, vol. 27, # 19, p. 3301 - 3311
[2] Synlett, 2003, # 2, p. 191 - 194
[3] Synthetic Communications, 2008, vol. 38, # 19, p. 3366 - 3374
[4] Chinese Chemical Letters, 2011, vol. 22, # 7, p. 827 - 830
[5] Synthetic Communications, 1998, vol. 28, # 15, p. 2773 - 2781
4'-Hydroxy-3'-nitroacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
4'-Hydroxy-3'-nitroacetophenone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| NanJing FineTech Chemical Co., Ltd | 025-52078417 17714198479 | sales@fine-chemtech.com | China | 275 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Lastest Price from 4'-Hydroxy-3'-nitroacetophenone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 4'-Hydroxy-3'-nitroacetophenone
6322-56-1
|
$1.00-100.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2025-04-04 | 4'-Hydroxy-3'-nitroacetophenone
6322-56-1
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2020-02-26 | 4'-Hydroxy-3'-nitroacetophenone
6322-56-1
|
1KG | 99.0% | 100 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 4'-Hydroxy-3'-nitroacetophenone
6322-56-1
- $1.00-100.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 4'-Hydroxy-3'-nitroacetophenone
6322-56-1
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 4'-Hydroxy-3'-nitroacetophenone
6322-56-1
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
