6-Bromo-3 H-isobenzofuran-1-one
- CAS No.
- 19477-73-7
- Chemical Name:
- 6-Bromo-3 H-isobenzofuran-1-one
- Synonyms
- 6-Bromophthalide;Roxadustat Impurity 12;6-bromo-1(3H)-isobenzofuanone;6-bromo-2-benzofuran-1(3H)-one;6-bromo-1H-isobenzofuran-1-one;6-Bromo-3 H-isobenzofuran-1-one;1(3H)-Isobenzofuranone, 6-broMo-;6-broMo-1,3-dihydro-2-benzofuran-1-one;1(3H)-Isobenzofuranone, 6-bromo-, 97%min;6-Bromophthalide (6-Bromo-3H-isobenzofuran-1-one)
- CBNumber:
- CB9119987
- Molecular Formula:
- C8H5BrO2
- Molecular Weight:
- 213.03
- MDL Number:
- MFCD03428561
- MOL File:
- 19477-73-7.mol
- MSDS File:
- SDS
| Melting point | 99.5 °C |
|---|---|
| Boiling point | 362.4±42.0 °C(Predicted) |
| Density | 1.742±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1S/C8H5BrO2/c9-6-2-1-5-4-11-8(10)7(5)3-6/h1-3H,4H2 |
| InChIKey | BELKVKMBIAENSA-UHFFFAOYSA-N |
| SMILES | C1(=O)C2=C(C=CC(Br)=C2)CO1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS03 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H272 |
| Precautionary statements | P501-P220-P210-P221-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 24/25 |
| HS Code | 29322090 |
6-Bromo-3 H-isobenzofuran-1-one price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR400356 | 6-Bromophthalide >98% | 19477-73-7 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR400356 | 6-Bromophthalide >98% | 19477-73-7 | 5g | $59 | 2026-06-04 | Buy |
| Apolloscientific | OR400356 | 6-Bromophthalide >98% | 19477-73-7 | 25g | $274 | 2026-06-04 | Buy |
| Apolloscientific | OR400356 | 6-Bromophthalide >98% | 19477-73-7 | 100g | $901 | 2026-06-04 | Buy |
| Matrix Scientific | 074102 | 6-Bromo-3H-isobenzofuran-1-one | 19477-73-7 | 5.00g | $60 | 2026-05-18 | Buy |
6-Bromo-3 H-isobenzofuran-1-one Chemical Properties, Uses, Production
Chemical Properties
Light red crystal
Synthesis
57319-65-0
19477-73-7
Step c: Synthesis of 6-bromoisobenzofuran-1(3H)-one Aqueous (22 mL) solution of NaNO2 (2.2 g, 0.040 mol) was added dropwise to a suspension of 6-aminoisobenzofuran-1(3H)-one (5.0 g, 0.030 mol) in HBr (70 mL, 48%), keeping the reaction temperature at 0 °C. After completion of dropwise addition, stirring of the reaction mixture was continued for 20 min. Subsequently, the reaction solution was transferred to a pre-cooled solution of CuBr (22 g, 0.21 mol) in HBr (48%, 23 mL). The resulting dark brown mixture was stirred for 20 min and then diluted with deionized water (200 mL) to precipitate an orange precipitate. The precipitate was collected by filtration, washed with saturated NaHCO3 solution and subsequently extracted with ethyl acetate (20 mL x 3). The organic phases were combined, dried with anhydrous Na2SO4 and concentrated under reduced pressure to afford 6-bromoisobenzofuran-1(3H)-one (5.4 g, 84% yield). 1H NMR (300 MHz, CDCl3) δ 8.05 (d, J = 1.8 Hz, 1H), 7.80 (dd, J = 8.1, 1.8 Hz, 1H), 7.39 (d, J = 8.1 Hz, 1H), 5.28 (s, 2H).
References
[1] Patent: US2008/9524, 2008, A1. Location in patent: Page/Page column 410
[2] Patent: EP1362856, 2003, A1. Location in patent: Page/Page column 159
[3] Patent: US2015/231142, 2015, A1. Location in patent: Paragraph 1265
[4] Chemistry of Heterocyclic Compounds, 2010, vol. 46, # 2, p. 140 - 145
[5] Journal of Medicinal Chemistry, 2015, vol. 58, # 9, p. 3997 - 4015
6-Bromo-3 H-isobenzofuran-1-one Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chongqing AoShe Biological Chemical Co., Ltd. | 023-63225655 13320248848 | 2366581735@qq.com | China | 501 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Suzhou Highfine Biotech Co., Ltd | 0512-69209928 18796809688 | zhouyingxiang@highfine.com | China | 472 | 75 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 |
View Latest Price from 6-Bromo-3 H-isobenzofuran-1-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-12 | Roxadustat Impurity 12 | 10mg | 98% | 500mg | ShenZhen H&D Pharmaceutical Technology Co., LTD | ||
 |
2021-07-13 | 6-BROMO-3 H-ISOBENZOFURAN-1-ONE
19477-73-7
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 6-BROMO-3 H-ISOBENZOFURAN-1-ONE
19477-73-7
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Roxadustat Impurity 12
- 98%
- ShenZhen H&D Pharmaceutical Technology Co., LTD
-
- 6-BROMO-3 H-ISOBENZOFURAN-1-ONE
19477-73-7
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 6-BROMO-3 H-ISOBENZOFURAN-1-ONE
19477-73-7
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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