METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE
- CAS No.
- 4093-28-1
- Chemical Name:
- METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE
- Synonyms
- ethyl p-acetaminosalicylate;Methyl 4-acetamidosalicylate;Methyl-4-(acetylamino)salicylat;Methyl 4-(Acetamido)-2-Methoxyb;methyl 4-(acetylamino)salicylate;Ethopabate USP Related Compound A;Methyl 4-(Acetylamino)-2-hydroxyben;METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE;Methyl-2-metroxy-4-acetylaminobenzoate;METHYL-2-METHOXY-4-ACETYLAMINOBENZOATE
- CBNumber:
- CB9129788
- Molecular Formula:
- C10H11NO4
- Molecular Weight:
- 209.2
- MDL Number:
- MFCD00458326
- MOL File:
- 4093-28-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methyl 4-Acetamido-2-hydroxybenzoate | TRC-M275280-5G | 5g | $67 |
| Methyl 4-Acetamido-2-hydroxybenzoate | TRC-M275280-10G | 10g | $121 |
| Methyl 4-acetamido-2-hydroxybenzoate 98% | OR8935 | 25g | $21 |
| Methyl 4-acetamido-2-hydroxybenzoate 98% | OR8935 | 100g | $36 |
| Methyl 4-acetamido-2-hydroxybenzoate 98% | OR8935 | 500g | $175 |
| More product size | |||
| Melting point | 146-147° |
|---|---|
| Boiling point | 405.1±35.0 °C(Predicted) |
| Density | 1.317±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 9.29±0.10(Predicted) |
| color | Light Orange to Light Brown |
| InChI | InChI=1S/C10H11NO4/c1-6(12)11-7-3-4-8(9(13)5-7)10(14)15-2/h3-5,13H,1-2H3,(H,11,12) |
| InChIKey | LCXHOHRQXZMSQN-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)C1=CC=C(NC(C)=O)C=C1O |
| CAS DataBase Reference | 4093-28-1(CAS DataBase Reference) |
| FDA UNII | 677WEL9DDE |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P280-P271 |
| HazardClass | IRRITANT |
| HS Code | 2916399090 |
| REACH Registrations | Active |
METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-M275280-5G | Methyl 4-Acetamido-2-hydroxybenzoate | 4093-28-1 | 5g | $67 | 2026-06-03 | Buy |
| TRC | TRC-M275280-10G | Methyl 4-Acetamido-2-hydroxybenzoate | 4093-28-1 | 10g | $121 | 2026-06-03 | Buy |
| Apolloscientific | OR8935 | Methyl 4-acetamido-2-hydroxybenzoate 98% | 4093-28-1 | 25g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR8935 | Methyl 4-acetamido-2-hydroxybenzoate 98% | 4093-28-1 | 100g | $36 | 2026-06-04 | Buy |
| Apolloscientific | OR8935 | Methyl 4-acetamido-2-hydroxybenzoate 98% | 4093-28-1 | 500g | $175 | 2026-06-04 | Buy |
METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE Chemical Properties,Uses,Production
Chemical Properties
Light Brown Solid
Uses
Methyl 4-Acetamido-2-hydroxybenzoate is a reagent used in the synthesis of Mosapride.
Synthesis
75-36-5
4136-97-4
4093-28-1
Methyl 4-amino-2-hydroxybenzoate (50.7 g, 303.6 mmol) was dissolved in ethyl acetate (750 mL) with stirred water (250 mL) and sodium bicarbonate solution (34.9 g). The mixture was cooled to 0°C over 15 minutes, followed by slow dropwise addition of acetyl chloride (29.7 mL, 415.5 mmol). The reaction mixture was gradually warmed to room temperature and stirred continuously for 2 hours. After completion of the reaction, the organic and aqueous layers were separated, the organic layer was washed with brine and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give the white solid product methyl 4-acetamido-2-hydroxybenzoate (63.5 g, 99% yield). The product was confirmed by NMR hydrogen spectrum (CDCl3): δ10.86 (broad single peak, 1H), 7.78 (double peak, J=8.6Hz, 1H), 7.23 (single peak, 1H), 7.16 (broad single peak, 1H), 7.10 (double peak, J=8.6Hz, 1H), 6.13 (broad single peak, 1H), 3.92 (single peak, 3H), 2.19 ( single peak, 3H); mass spectrum (m/z): 208 (MH)+.
References
[1] Patent: WO2013/42135, 2013, A1. Location in patent: Page/Page column 11
[2] Patent: US2014/187581, 2014, A1. Location in patent: Paragraph 0095-0097
[3] Organic Process Research and Development, 2010, vol. 14, # 1, p. 92 - 98
[4] Patent: US2016/251376, 2016, A1. Location in patent: Paragraph 0955; 0956; 0957
[5] Bioorganic and Medicinal Chemistry Letters, 1996, vol. 6, # 22, p. 2657 - 2662
METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 17389186172 | 1077@dideu.com | China | 3999 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52693 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49859 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +86-15965530500 | nickzhang@hangyubiotech.com | China | 9932 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +86-15355479329 | market18@leapchem.com | China | 43303 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501 | product@acmec-e.com | China | 33301 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 54746 | 58 | |
| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | ellena@amitychem.com | China | 43392 | 58 |
View Lastest Price from METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-07 | METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE
4093-28-1
|
$20.00-30.00 | 1KG | 99% | 200000KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | Methyl 4-acetamido-2-hydroxybenzoate
4093-28-1
|
$1.00 | 1kg | 98% | 200kg | Career Henan Chemical Co |
-
- METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE
4093-28-1
- $20.00-30.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Methyl 4-acetamido-2-hydroxybenzoate
4093-28-1
- $1.00
- 98%
- Career Henan Chemical Co
