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Methyl 4-acetamido-2-methoxybenzoate

Methyl 4-acetamido-2-methoxybenzoate structure

CAS No.: 4093-29-2

Chemical Name:: Methyl 4-acetamido-2-methoxybenzoate

Synonyms: Metoclopramide EP Impurity D;MetoclopraMide Related CoMpound D;Metoclopramide RC D (USP);Metoclopramide BP Impurity D;Methyl 4-Acetamido-o-anisate;MetocloprDmide EP Impurity D;4-ACETYLAMINO-2-METHOXYBENZOATE;methyl 4-(acetylamino)-o-anisate;Metoclopramide related Complex D;Cinibide Tartaric acid impurity 34

CBNumber:: CB5439124

Molecular Formula:: C11H13NO4

Molecular Weight:: 223.23

MDL Number:: MFCD00065258

MOL File:: 4093-29-2.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:49

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Methyl 4-acetamido-2-methoxybenzoate Properties

Melting point	128.0 to 132.0 °C
Boiling point	417.5±35.0 °C(Predicted)
Density	1.210±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Sparingly), Methanol (Slightly), Water (Slightly)
form	Solid
pka	14.09±0.70(Predicted)
color	Off-White to Light Beige
InChI	InChI=1S/C11H13NO4/c1-7(13)12-8-4-5-9(11(14)16-3)10(6-8)15-2/h4-6H,1-3H3,(H,12,13)
InChIKey	OERVVBDWGVOBIS-UHFFFAOYSA-N
SMILES	C(OC)(=O)C1=CC=C(NC(C)=O)C=C1OC
CAS DataBase Reference	4093-29-2(CAS DataBase Reference)
FDA UNII	W4UJW899BA
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H319

Precautionary statements

P264-P270-P280-P301+P312-P305+P351+P338-P337+P313

WGK Germany

HS Code

2924296000

NFPA 704

	0
2		0

Methyl 4-acetamido-2-methoxybenzoate price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S447994	METHYL 4-ACETAMIDO-2-METHOXYBENZOATE Aldrich^CPR	4093-29-2	1 unit	$185	2025-07-31	Buy
Sigma-Aldrich	PHR2285	Metoclopramide Related Compound D Pharmaceutical Secondary Standard; Certified Reference Material	4093-29-2	100MG	$743	2025-07-31	Buy
Sigma-Aldrich	1440841	Metoclopramide Related Compound D	4093-29-2	15mg	$1250	2025-07-31	Buy
Sigma-Aldrich	S447994	METHYL 4-ACETAMIDO-2-METHOXYBENZOATE Aldrich	4093-29-2	1g	$179	2024-03-01	Buy
TCI Chemical	M2776	Methyl 4-Acetamido-2-methoxybenzoate >98.0%(GC)	4093-29-2	5g	$28	2025-07-31	Buy

Product number	Packaging	Price	Buy
S447994	1 unit	$185	Buy
PHR2285	100MG	$743	Buy
1440841	15mg	$1250	Buy
S447994	1g	$179	Buy
M2776	5g	$28	Buy

Methyl 4-acetamido-2-methoxybenzoate Chemical Properties,Uses,Production

Uses

Methyl 4-acetamido-2-methoxybenzoate (Metoclopramide EP Impurity D) is an impurity of bromopride (B686645), which is an antiemetic.

Synthesis

27492-84-8

108-24-7

4093-29-2

To a solution of methyl 4-amino-2-methoxybenzoate (501 mg, 2.77 mmol) in anhydrous ethanol (8 mL) was slowly added acetic anhydride (0.42 mL, 4.44 mmol, 1.6 equiv). The resulting clarified solution was heated to 60-65 °C and the reaction was maintained at this temperature with stirring for 2 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature and the solvent was subsequently removed using a rotary evaporator. The residue was washed sequentially with deionized water (10 mL) and saturated sodium bicarbonate solution (10 mL) and then extracted with ethyl acetate (20 mL in two portions of 10 mL each). The organic phases were combined, washed sequentially with deionized water and saturated saline, and dried over anhydrous magnesium sulfate. After filtration, the organic phase was concentrated under reduced pressure to give methyl 4-acetamido-2-methoxybenzoate (545 mg, 88% yield) as a white solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 2.07 (s, 3H, AcNH-4), 3.74 (s, 3H, OMe-2 or COOMe), 3.77 (s, 3H, COOMe or OMe-2), 7.19 (br d, J = 8.8 Hz, 1H, H-5), 10.22 (s, 1H, NH ). Ref: J. Med. Chem. 2007, 50(15), 3561-3572.

References

[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 15, p. 3561 - 3572
[2] Patent: WO2011/123890, 2011, A1. Location in patent: Page/Page column 118-119
[3] Patent: WO2015/26792, 2015, A1. Location in patent: Paragraph 0542
[4] Archiv der Pharmazie, 1980, vol. 313, # 4, p. 297 - 300
[5] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 7, p. 2311 - 2315

Methyl 4-acetamido-2-methoxybenzoate Preparation Products And Raw materials

Raw materials

METHYL 4-AMINOSALICYLATE 4-Aminosalicylic acid Dimethyl sulfate METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE Methyl 4-amino-2-methoxybenzoate

Acetyl chloride Iodomethane Acetic anhydride Sodium bicarbonate

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Preparation Products

Methyl 4-acetamido-5-bromo-2-methoxybenzoate methyl 4,5-diamino-o-anisate 4-AMINO-2-METHOXYBENZOIC ACID Methyl 4-acetamido-5-chloro-2-methoxybenzoate methyl 4-acetamido-5-iodo-2-methoxybenzoate

6-methoxy-1H-benzotriazole-5-carboxylic acid

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Methyl 4-acetamido-2-methoxybenzoate Suppliers

Global( 231)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 +86-18192627656	1059@dideu.com	China	3527	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5251	58
Changzhou Rokechem Technology Co., Ltd.	18758118018	sales001@rokechem.com	China	255	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21622	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	340	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8826	58

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Changzhou Rokechem Technology Co., Ltd.	58
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Anqing Chico Pharmaceutical Co., Ltd.	58
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Standardpharm Co. Ltd.	58
Neostar United (Changzhou) Industrial Co., Ltd.	58

View Lastest Price from Methyl 4-acetamido-2-methoxybenzoate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-09-11	Methyl 4-acetamido-2-methoxybenzoate 4093-29-2	US $0.00-0.00 / Kg/Drum	1KG	98%min	1000kg	WUHAN FORTUNA CHEMICAL CO., LTD
2025-07-25	Methyl 4-acetamido-2-methoxybenzoate 4093-29-2	US $0.00 / kg	1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-05-26	Methyl 4-Acetamido-2-Methoxybenzoate 4093-29-2	US $5.00-2.00 / KG	1KG	99%	10000kg	Hebei Chuanghai Biotechnology Co,.LTD

Methyl 4-acetamido-2-methoxybenzoate
4093-29-2
US $0.00-0.00 / Kg/Drum
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Methyl 4-acetamido-2-methoxybenzoate
4093-29-2
US $0.00 / kg
99%
Shaanxi Dideu New Materials Co. Ltd

Methyl 4-Acetamido-2-Methoxybenzoate
4093-29-2
US $5.00-2.00 / KG
99%
Hebei Chuanghai Biotechnology Co,.LTD

Methyl 4-acetamido-2-methoxybenzoate Spectrum

Methyl 4-acetamido-2-methoxybenzoate(4093-29-2)¹HNMR

4093-29-2(Methyl 4-acetamido-2-methoxybenzoate)Related Search:

2-Methoxybenzoic acid 4-Methoxybenzoic acid Methyl 2-iodobenzoate METSULFURON METHYL 4-Aminobenzoic acid

Methyl acetate Methylparaben 4-Acetylbenzoic acid Methyl acrylate Acetaminophen

Methyl methoxyacetate 4-Dimethylaminobenzoic acid Kresoxim-methyl Bensulfuron methyl Methyl benzoate

Thiophanate-methyl Methyl Methyl 4-acetamido-5-chloro-2-methoxybenzoate

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4-acetamide-2-methoxybenzoicacid-methylester Methyl4-acetylamino-2-methoxybenzoate 4-ACETYLAMINO-2-METHOXY-BENZOIC ACID METHYL ESTER METHYL 4-ACETAMIDO-2-METHOXYBENZOATE methyl 4-(acetylamino)-o-anisate 4-ACETAMIDO-2-METHOXYBENZOIC ACID METHYL ESTER Methyl - 4 - Acetamido - 2 – Methoxy Benzoate(Methopabate) () METHYL4-ACETAMINO-2-METHOXYBENZOATE 4-ACETYLAMINO-2-METHOXYBENZOATE 4-ACETAMIDO-2-METHOXYBENZOIC ACID METHYL ESTER (METHOPABATE) 2-Methoxy-4-acetylaMino Methyl benzoate MetoclopraMide Related CoMpound D Metoclopramide RC D (USP) Methyl-4-acetylaMino-2-Methoxybenzoate (Methyl-4-acetaMido-o-anisate) Benzoic acid,4-(acetylamino)-2-methoxy-, methyl ester Metoclopramide EP Impurity D Metoclopramide BP Impurity D 4-acetyloxy-2-methoxybenzoic acid methyl ester Metoclopramide Impurity 4（Metoclopramide EP Impurity D） Methyl 4-(Acetylamino)-2-methoxyben 4-Acetamido-o-anisic Acid Methyl Ester Methyl 4-Acetamido-o-anisate METHYL 4-ACETAMIDO-2-METHOXYBENZOATE 4093-29-2 Metoclopramide EP Impurity DQ: What is Metoclopramide EP Impurity D Q: What is the CAS Number of Metoclopramide EP Impurity D Q: What is the storage condition of Metoclopramide EP Impurity D Q: What are the applications of Metoclopramide EP Impurity D Methyl4-acetamido-2-methoxybenzoate(MetoclopramideImpurity) Metoclopramide Related Compound D (methyl 4-acetamido-2-methoxybenzoate) (1440841) MetocloprDmide EP Impurity D Metoclopramide Hydrochloride Monohydrate Impurity D Metoclopramide Hydrochloride Monohydrate EP Impurity D Metoclopramide USP Related Compound D Benzoic acid, 4-(acetylamino)-2-methoxy-, methyl ester (9CI, ACI) 4-(acetylamino)-2-methoxy-Benzoic acid methyl ester (9CI ACI) Cinibide Tartaric acid impurity 34 Metoclopramide related Complex D Metoclopramide EP Impurity D (Metoclopramide USP Related Compound D) 4093-29-2 4093-29-2