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trifluoromethanesulfonanilide

trifluoromethanesulfonanilide Structure
trifluoromethanesulfonanilide structure
CAS No.
456-64-4
Chemical Name:
trifluoromethanesulfonanilide
Synonyms
1,1,1-trifluoro-N-phenylmethanesulfonamide;N-[(Trifluoromethyl)sulfonyl]aniline;Phenyltriflamide;N-Phenyltriflamide;Trifluoromethanesulfonaniline;trifluoromethanesulfonanilide;N-Phenyltrifluoromethanesulfonamide;1,1,1-Trifluoromethanesulfonanilide;1,1,1-trifluoro-N-phenylmethylsulfonyl;N-Phenyl-1,1,1-trifluoromethanesulfonamide
CBNumber:
CB91310457
Molecular Formula:
C7H6F3NO2S
Molecular Weight:
225.19
MDL Number:
MFCD00521820
MOL File:
456-64-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-04 16:00:12
Product description Number Pack Size Price
Trifluoromethanesulfonanilide >98.0%(HPLC)(T) T2985 1g $113
Trifluoromethanesulfonanilide >98.0%(HPLC)(T) T2985 5g $380
Trifluoromethanesulfonanilide Asreported 291791 250mg $303
Trifluoromethanesulfonanilide Asreported 291791 500mg $415
Trifluoromethanesulfonanilide Asreported 291791 1g $556
More product size
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trifluoromethanesulfonanilide Properties

Melting point 65-66℃
Boiling point 233.5±50.0 °C(Predicted)
Density 1.539±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
form powder to crystal
pka 4.35±0.10(Predicted)
color White to Almost white

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P310+P330-P405
RIDADR  UN 2811 6.1/PG III
RTECS  PB0482000
HazardClass  6.1
PackingGroup  III
HS Code  2904100090
REACH Registrations Active
Limited Quantities 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

trifluoromethanesulfonanilide price More Price(46)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical T2985 Trifluoromethanesulfonanilide >98.0%(HPLC)(T) 456-64-4 1g $113 2026-04-30 Buy
TCI Chemical T2985 Trifluoromethanesulfonanilide >98.0%(HPLC)(T) 456-64-4 5g $380 2026-04-30 Buy
Usbiological 291791 Trifluoromethanesulfonanilide Asreported 456-64-4 250mg $303 2026-06-03 Buy
Usbiological 291791 Trifluoromethanesulfonanilide Asreported 456-64-4 500mg $415 2026-06-03 Buy
Usbiological 291791 Trifluoromethanesulfonanilide Asreported 456-64-4 1g $556 2026-06-03 Buy
Product number Packaging Price Buy
T2985 1g $113 Buy
T2985 5g $380 Buy
291791 250mg $303 Buy
291791 500mg $415 Buy
291791 1g $556 Buy

trifluoromethanesulfonanilide Chemical Properties,Uses,Production

Synthesis Reference(s)

Tetrahedron Letters, 14, p. 3839, 1973 DOI: 10.1016/S0040-4039(01)87051-9

Synthesis

Trifluoromethanesulfonic anhydride

358-23-6

Aniline

62-53-3

trifluoromethanesulfonanilide

456-64-4

Under stirring conditions, 4 g (2.4 mL) of trifluoromethanesulfonic anhydride was slowly added dropwise to 15 mL of aniline. After the dropwise addition was completed, the reaction mixture was continued to be stirred for 30 minutes. Upon completion of the reaction, the reaction solution was acidified with 10% hydrochloric acid solution, followed by filtration to collect the precipitate precipitated. The precipitate was washed several times with water, dried and purified by sublimation. Finally 2.9 g (90% yield) of the target compound 1,1,1 -trifluoro-N-phenylmethanesulfonamide was obtained under vacuum as a white powder (19F NMR δF -75.30 ppm).

References

[1] Journal of the American Chemical Society, 2018, vol. 140, # 9, p. 3202 - 3205
[2] Russian Journal of Organic Chemistry, 2016, vol. 52, # 8, p. 1112 - 1117
[3] Zh. Org. Khim., 2016, vol. 52, # 8, p. 1122 - 1127,6
[4] Organic Letters, 2016, vol. 18, # 13, p. 3130 - 3133
[5] Tetrahedron, 1975, vol. 31, # 20, p. 2517 - 2521

trifluoromethanesulfonanilide Preparation Products And Raw materials

Raw materials

Trifluoromethanesulfonic anhydride Aniline

Preparation Products

1-CYCLOHEXEN-1-YL TRIFLUOROMETHANE-

trifluoromethanesulfonanilide Suppliers

Global( 81)Suppliers
Supplier Tel Email Country ProdList Advantage
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10399 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +86-189 4982 3763 sales@tnjchem.com China 34526 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 17705817739 info@dycnchem.com China 52693 58
GIHI CHEMICALS CO.,LIMITED 		+86-571-86217390; +8618058761490 info@gihichemicals.com China 49859 58
Aladdin Scientific 		tp@aladdinsci.com United States 50108 58
Suzhou ARTK Medchem Co., Ltd. 		+86-18168183658 sales1@artkmedchem.com China 39007 58
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. 		+8618950047208 ellena@amitychem.com China 43392 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131885 58
Nanjing Hengbei Chemicals Co., Ltd. 025-58393656 18913958656 sales@hengbeichem.cn China 236 58
Henan Aochuang Chemical Co.,Ltd. +86-0371-63689365 +8618638391208 sales@aochuangchem.com China 9322 58
Supplier Advantage
Shenzhen Nexconn Pharmatechs Ltd 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
GIHI CHEMICALS CO.,LIMITED 		58
Aladdin Scientific 		58
Suzhou ARTK Medchem Co., Ltd. 		58
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. 		58
Amadis Chemical Company Limited 		58
Nanjing Hengbei Chemicals Co., Ltd. 58
Henan Aochuang Chemical Co.,Ltd. 58

View Lastest Price from trifluoromethanesulfonanilide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
trifluoromethanesulfonanilide pictures 2025-04-04 trifluoromethanesulfonanilide
456-64-4
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

456-64-4(trifluoromethanesulfonanilide)Related Search:

Trifluoromethanesulfonyl bromide Trifluoromethyl trifluorovinyl ether Benzoic acid (trifluoromethanesulfonic acid)anhydride Saprisartan FLUORIDAMID
trifluoromethanesulfonanilide MEFLUIDIDE N-Phenyl-bis(trifluoromethanesulfonimide) Nickel, bis[N-[1-ethyl-1,2,3,4-tetrahydro-6-[(1,3,4-thiadiazol-2-yl-kN3)azo-kN1]-7-quinolinyl]-1,1,1-trifluoromethanesulfonamidato-kN]- Nickel, bis[N-[6-[2-(4,5-dicyano-1-methyl-1H-imidazol-2-yl-kN3)diazenyl-kN1]-1,2,3,4-tetrahydro-1-methyl-7-quinolinyl]-1,1,1-trifluoromethanesulfonamidato-kN]-
PERFLUIDONE Methanesulfonamide, 1,1,1-trifluoro-N-[1,2,3,4-tetrahydro-1-(2-methylpropyl)-7-quinolinyl]- Zinc,bis[1,1,1-trifluoro-N-[1,2,3,4-tetrahydro-1-(2-methylpropyl)-6-[(1,3,4-thiadiazol-2-yl-kN3)azo-kN1]-7-isoquinolinyl]methanesulfonamidato-kN]- Methanesulfonamide, N-(1-ethyl-1,2,3,4-tetrahydro-7-quinolinyl)-1,1,1-trifluoro- Triflumidate
N-(2-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]SULFANYL)PHENYL)(TRIFLUORO)METHANESULFONAMIDE BIS(4-TRIFLUOROMETHYLSULFONAMIDOPHENYL)-1,4-DIISOPROPYLBENZENE C,C,C-TRIFLUORO-N,N-DIPHENYL-METHANESULFONAMIDE

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trifluoromethanesulfonanilide Methanesulfonamide, 1,1,1-trifluoro-N-phenyl- 1,1,1-trifluoro-N-phenyl-methanesulfonamide 1,1,1-Trifluoromethanesulfonanilide Methanesulfonanilide,1,1,1-trifluoro- (6CI,8CI) 1,1,1-Trifluoro-N-phenylmethanesulphonamide N-Phenyl-1,1,1-trifluoromethanesulfonamide N-Phenyltriflamide N-Phenyltrifluoromethanesulfonamide Phenyltriflamide Trifluoromethanesulfonaniline 1,1,1-Trifluoro-N-phenylmethanesulfonamide - [T93999] 1,1,1-trifluoro-N-phenylmethylsulfonyl 1,1,1-trifluoro-N-phenylmethanesulfonamide N-[(Trifluoromethyl)sulfonyl]aniline 456-64-4 456644