cosalane
- CAS No.
- 154212-56-3
- Chemical Name:
- cosalane
- Synonyms
- cosalane;NSC-658586;NSC 658586;Benzoic acid, 3,3'-[4-(3β,5α)-cholestan-3-yl-1-butenylidene]bis[5-chloro-6-hydroxy-;5-{4-[(1R,3aS,3bR,5aS,7S,9aS,9bS,11aR)-9a,11a-dimethyl-1-[(2R)-6-methylheptan-2-yl]-hexadecahydro-1H-cyclopenta[a]phenanthren-7-yl]-1-(3-carboxy-5-chloro-4-hydroxyphenyl)but-1-en-1-yl}-3-chloro-2-hydroxybenzoic acid
- CBNumber:
- CB91338121
- Molecular Formula:
- C45H60Cl2O6
- Molecular Weight:
- 767.86
- MDL Number:
- MFCD00920790
- MOL File:
- 154212-56-3.mol
- MSDS File:
- SDS
| Boiling point | 797.4±60.0 °C(Predicted) |
|---|---|
| Density | 1.191±0.06 g/cm3(Predicted) |
| pka | 2.07±0.14(Predicted) |
| form | Solid |
| color | White to off-white |
| Water Solubility | 1.4ug/L(temperature not stated) |
| FDA UNII | 2R84Y6217J |
cosalane price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0077983 | Cosalane 98.82% | 154212-56-3 | 1mg | $487 | 2026-06-04 | Buy |
| ChemScene | CS-0077983 | Cosalane 98.82% | 154212-56-3 | 5mg | $1137 | 2026-06-04 | Buy |
| ChemScene | CS-0077983 | Cosalane 98.82% | 154212-56-3 | 10mg | $1408 | 2026-06-04 | Buy |
| aablocks | AA00AXI5 | Cosalane | 154212-56-3 | 1mg | $318 | 2026-05-28 | Buy |
| aablocks | AA00AXI5 | Cosalane | 154212-56-3 | 5mg | $715 | 2026-05-28 | Buy |
cosalane Chemical Properties,Uses,Production
Uses
Cosalane (NSC 658586) is a potent inhibitor of HIV replication. Cosalane has an intrinsic ability to block human and murine CCR7 function in vitro in response to both of its natural ligands, CCL19 and CCL21, with the IC50 of 0.207/2.66 μM in human for CCL19/CCL21 and 0.193/1.98 μM in murine, respectively[1][2].
IC 50
Human CCR7; Murine CCR7
References
[1] Kenneth A Fowler, et al. The Ex Vivo Treatment of Donor T Cells with Cosalane, an HIV Therapeutic and Small-Molecule Antagonist of CC-Chemokine Receptor 7, Separates Acute Graft-versus-Host Disease from Graft-versus-Leukemia Responses in Murine Hematopoietic Stem Cell Transplantation Models. Biol Blood Marrow Transplant. 2019 Jun;25(6):1062-1074. DOI:10.1016/j.bbmt.2019.01.022
[2] Emily A Hull-Ryde, et al. Identification of Cosalane as an Inhibitor of Human and Murine CC-Chemokine Receptor 7 Signaling via a High-Throughput Screen. SLAS Discov. 2018 Dec;23(10):1083-1091. DOI:10.1177/2472555218780917
cosalane Preparation Products And Raw materials
Raw materials
Preparation Products
cosalane Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4861 | 55 | |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
