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ChemicalBook >> CAS DataBase List >>6-Amino-3,4-dihydro-1H-quinolin-2-one

6-Amino-3,4-dihydro-1H-quinolin-2-one

6-Amino-3,4-dihydro-1H-quinolin-2-one Structure
6-Amino-3,4-dihydro-1H-quinolin-2-one structure
CAS No.
22246-13-5
Chemical Name:
6-Amino-3,4-dihydro-1H-quinolin-2-one
Synonyms
AKOS BB-9801;6-amino-3,4-dihydrocarbostyril;6-Amino-3,4-dihydroquinolin-2(1H);6-Amino-3,4-dihydro-1H-quinolin-2-one;6-AMino-1,3,4-trihydro-quinolin-2-one;6-amino-3,4-dihydro-2(1 )-quinalinone;6-AMINO-3,4-DIHYDRO-2(1H)-QUINOLINONE;6-Amino-3,4-dihydroquinoline-2(1H)-one;6-aMino-3,4-dihydro-2(1H )-quinalinone;2(1H)-Quinolinone, 6-amino-3,4-dihydro-
CBNumber:
CB9138360
Molecular Formula:
C9H10N2O
Molecular Weight:
162.19
MDL Number:
MFCD00559318
MOL File:
22246-13-5.mol
MSDS File:
SDS
Last updated:2026-09-12 18:56:00
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6-Amino-3,4-dihydro-1H-quinolin-2-one Properties

Melting point 174-176 °C
Boiling point 423.0±45.0 °C(Predicted)
Density 1.237±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 14.47±0.20(Predicted)
Appearance Light yellow to light brown Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2933499090

6-Amino-3,4-dihydro-1H-quinolin-2-one price More Price(48)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR451145 6-Amino-3,4-dihydroquinolin-2(1H)-one 95% 22246-13-5 5g $551 2026-06-04 Buy
Matrix Scientific 119773 6-Amino-3,4-dihydroquinolin-2(1H)-one 22246-13-5 1.00g $67 2026-05-18 Buy
Matrix Scientific 119773 6-Amino-3,4-dihydroquinolin-2(1H)-one 22246-13-5 5.00g $238 2026-05-18 Buy
Matrix Scientific 119773 6-Amino-3,4-dihydroquinolin-2(1H)-one 22246-13-5 10.00g $467 2026-05-18 Buy
Synthonix A22440 6-Amino-3,4-dihydroquinolin-2(1H)-one 97% 22246-13-5 100mg $24 2026-05-06 Buy
Product number Packaging Price Buy
OR451145 5g $551 Buy
119773 1.00g $67 Buy
119773 5.00g $238 Buy
119773 10.00g $467 Buy
A22440 100mg $24 Buy

6-Amino-3,4-dihydro-1H-quinolin-2-one Chemical Properties, Uses, Production

Uses

6-Amino-3,4-dihydrocarbostyril is a useful synthetic compound used to prepare cardiotonic agents.

Synthesis

3,4-Dihydro-6-nitro-2(1H)-quinolinone

22246-16-8

6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE

22246-13-5

At 0 °C, 6-nitro-3,4-dihydroquinolin-2(1H)-one (3 g) was dissolved in methanol (60 mL) and zinc powder (5 eq.) and ammonium chloride (5 eq.) were added sequentially. The reaction mixture was stirred at room temperature for 1 h. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was filtered through a bed of diatomaceous earth and the filtrate was concentrated under reduced pressure. The residue was dissolved in a dichloromethane solution containing 5% methanol and subsequently washed with water. The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford 6-amino-3,4-dihydroquinolin-2(1H)-one (2.3 g in 91% yield. The product was characterized by 1H NMR (DMSO-d6, 400MHz): δ 9.654 (broad single peak, 1H), 6.53 (double peak, 1H), 6.378-6.334 (multiple peaks, 2H), 4.707 (broad single peak, 2H), 2.699 (triple peak, 2H), 2.330 (triple peak, 2H).

References

[1] Patent: WO2015/38417, 2015, A1. Location in patent: Page/Page column 90; 91
[2] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 16, p. 4606 - 4609
[3] Patent: WO2006/71940, 2006, A2. Location in patent: Page/Page column 416
[4] Proceedings of the Imperial Academy (Tokyo), 1939, vol. 15, p. 148,153
[5] Chem. Zentralbl., 1939, vol. 110, # II, p. 3089

6-Amino-3,4-dihydro-1H-quinolin-2-one Preparation Products And Raw materials

Raw materials

3,4-Dihydro-6-nitro-2(1H)-quinolinone Ammonium chloride Methanol ZINC

Preparation Products

6-Hydroxy-2(1H)-3,4-dihydroquinolinone

6-Amino-3,4-dihydro-1H-quinolin-2-one Suppliers

Global Suppliers ( 74)
Supplier Tel Email Country ProdList Advantage
PharmaBlock Sciences (Nanjing),Inc. 025-86918202 4000255188 sales@pharmablock.com China 5000 55
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
Chiba Pharmaceutical Science and technology Co, Ltd. 0531-81313138 13066006660 chibapharm@foxmail.com China 3996 55
Shanghai Keepontech Co.,Ltd 021-54849683 13601642561 sales@keepontech.com China 998 59
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29977 65
EnliPharma Technology Co., Ltd 0551-66399836 18955197623 sales@enlipharma.com China 1875 55
Amatek Scientific Co. Ltd. 0512-56316828 4008675858 sales@amateksci.com China 9848 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Beijing Wuyunyongchang Science and Technology Co., Ltd. 15210642910 moon5.1days@126.com China 202 56
ShangHai KenEn Chemical Technology Co., Ltd. 13120367189;18621755571 mychess007@163.com China 1994 55
Supplier Advantage
PharmaBlock Sciences (Nanjing),Inc. 55
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
Chiba Pharmaceutical Science and technology Co, Ltd. 55
Shanghai Keepontech Co.,Ltd 59
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
EnliPharma Technology Co., Ltd 55
Amatek Scientific Co. Ltd. 55
Bide Pharmatech Ltd. 60
Beijing Wuyunyongchang Science and Technology Co., Ltd. 56
ShangHai KenEn Chemical Technology Co., Ltd. 55

View Latest Price from 6-Amino-3,4-dihydro-1H-quinolin-2-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE pictures 2019-07-10 6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE
22246-13-5
 $8.80 1KG 97%-99% 100kg Career Henan Chemical Co

6-Amino-3,4-dihydro-1H-quinolin-2-one Spectrum

6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE(22246-13-5)1HNMR

22246-13-5 (6-Amino-3,4-dihydro-1H-quinolin-2-one) Related Search:

Aminoguanidine bicarbonate 6-(1-Piperazinyl)-3,4-dihydrocarbostyril monohydrobromide 6-Piperazin-1-yl-3,4-dihydro-1H-quinolin-2-one 6,8-Dinitro-3,4-dihydro-1H-quinolin-2-one 6-Amino-3,4-dihydro-1H-quinolin-2-one
VESNARINONE 3,4-Dihydro-6-nitro-2(1H)-quinolinone AURORA KA-4837 AURORA KA-2344 AURORA KA-5364
AURORA KA-5365 AURORA KA-4790

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6-AMINO-3,4-DIHYDRO-2(1H)-QUINOLINONE AKOS BB-9801 6-amino-3,4-dihydro-2(1 )-quinalinone 6-AMino-1,3,4-trihydro-quinolin-2-one 6-aMino-3,4-dihydro-2(1H )-quinalinone 6-amino-3,4-dihydrocarbostyril 6-Amino-3,4-dihydroquinoline-2(1H)-one 6-Amino-3,4-dihydroquinolin-2(1H) 2(1H)-Quinolinone, 6-amino-3,4-dihydro- 6-Amino-3,4-dihydro-1H-quinolin-2-one 22246-13-5 pharmacetical