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VESNARINONE

VESNARINONE structure

CAS No.: 81840-15-5

Chemical Name:: VESNARINONE

Synonyms: Arkin;CS-2139;0PC-8212;OPC 8212;VESNARINONE;Piteranometozine;Vesnarinone(OPC8212);VESNARINONE USP/EP/BP;OPC8212;OPC 8212;OPC-8212;Vesnarinone, 10 mM in DMSO

CBNumber:: CB6750484

Molecular Formula:: C22H25N3O4

Molecular Weight:: 395.45

MDL Number:: MFCD00867124

MOL File:: 81840-15-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-19 21:59:04

Product description	Number	Pack Size	Price
Vesnarinone ≥98%	23489	1mg	$36
Vesnarinone ≥98%	23489	5mg	$153
Vesnarinone ≥98%	23489	10mg	$268
Vesnarinone ≥98%	23489	25mg	$587
Vesnarinone ≥98%	23489	1mg	$32
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VESNARINONE Properties

Melting point	238.1-239.5° (Tominaga); mp 238.1-239.8° (Shimizu)
Boiling point	519.41°C (rough estimate)
Density	1.2414 (rough estimate)
refractive index	1.6500 (estimate)
storage temp.	Store at -20°C
solubility	DMSO:9.84(Max Conc. mg/mL);24.88(Max Conc. mM) DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.26(Max Conc. mM) DMF:3.0(Max Conc. mg/mL);7.59(Max Conc. mM)
pka	2.86(at 25℃)
form	A crystalline solid
color	White to off-white
FDA UNII	5COW40EV8M

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

NFPA 704

	0
3		0

VESNARINONE price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	23489	Vesnarinone ≥98%	81840-15-5	1mg	$36	2026-04-30	Buy
Cayman Chemical	23489	Vesnarinone ≥98%	81840-15-5	5mg	$153	2026-04-30	Buy
Cayman Chemical	23489	Vesnarinone ≥98%	81840-15-5	10mg	$268	2026-04-30	Buy
Cayman Chemical	23489	Vesnarinone ≥98%	81840-15-5	25mg	$587	2026-04-30	Buy
Cayman Chemical	23489	Vesnarinone ≥98%	81840-15-5	1mg	$32	2024-03-01	Buy

Product number	Packaging	Price	Buy
23489	1mg	$36	Buy
23489	5mg	$153	Buy
23489	10mg	$268	Buy
23489	25mg	$587	Buy
23489	1mg	$32	Buy

VESNARINONE Chemical Properties,Uses,Production

Description

Vesnarinone is a new orally-active positive inotropic agent introduced for the treatment of congestive heart failure. It exerts a positive inotropic effect on the heart and has a peripheral vasodilatory effect. Vesnarinone is claimed not to affect heart rate or aggravate arrhythmia.

Description

Vesnarinone is an inhibitor of phosphodiesterase 3 (PDE3; IC₅₀s = 10.7 and 13.2 μM for PDE3A and PDE3B, respectively). It also inhibits ether-a-go-go-related gene 1 (ERG1) channels (IC₅₀ = 1.1 μM in HEK293T cells expressing human ERG1). Vesnarinone (3-300 μM) increases contractile tension in isolated ventricular muscles of dog, cat, rabbit, and guinea pig in a dose-dependent manner. Oral and i.v. administration of vesnarinone increases right ventricular pressure with no effect on heart rate in dog models of tricuspid insufficiency- and pulmonary stenosis-induced congestive heart failure. It also increases contractility and coronary flow while decreasing heart rate in a guinea pig model of aortic stenosis-induced congestive heart failure. Formulations containing vesnarinone have been used for the treatment of congestive heart failure.

Chemical Properties

Colorless granular crystals from ethanol-chloroform, melting point 238.1-239.5°C; also odorless and tasteless light yellow crystalline powder, melting point 238.1-239.8°C. UV maximum absorption (methanol, ethanol, chloroform): 271 nm (ε25100, 25200, 23000, C=10μg/m1). Solubility % (25°C): glacial acetic acid 18.68, chloroform 14.19, benzyl alcohol 5.913, N-methyl-2-pyrrolidone 3.407, dimethyl sulfoxide 2.509, cyclobutanesulfone 1.229, dimethylformamide 1.179, dioxane 0.1653, methanol 0.1151, acetone 0.06389, ethanol 0.04005, water 0.002086. pKa 2.86.

Originator

Otsuka (Japan)

Uses

Cardiotonic.

Definition

ChEBI: Arkin (TN) is an organic molecular entity.

brand name

Arkin (Otsuka America);Arkin-Z.

References

[1] MOHSEN NIKPOUR . Design, synthesis and biological evaluation of 6-(benzyloxy)-4-methylquinolin-2(1H)-one derivatives as PDE3 inhibitors[J]. Bioorganic & Medicinal Chemistry, 2010, 18 2: Pages 855-862. DOI: 10.1016/j.bmc.2009.11.044
[2] Y KATAYAMA. Inhibitory effects of vesnarinone on cloned cardiac delayed rectifier K(+) channels expressed in a mammalian cell line.[J]. Journal of Pharmacology and Experimental Therapeutics, 2000, 294 1: 339-346.
[3] FELDMAN A M. Pharmacologic Properties and Clinical Evaluation of the New Inotropic Agent OPC-8212 (Vesnarinone)[J]. Cardiovascular Therapeutics, 1993, 11 1: 1-11. DOI: 10.1111/j.1527-3466.1993.tb00264.x
[4] MD S E R, FACC James B Y M Richard Holubkov PhD, FACC Jay N C M B G White PhD, et al. Estrogen is associated with improved survival in aging women with congestive heart failure: analysis of the vesnarinone studies[J]. Journal of the American College of Cardiology, 2000, 36 2: Pages 529-533. DOI: 10.1016/s0735-1097(00)00738-5

VESNARINONE Preparation Products And Raw materials

Raw materials

4-Methylanisole 3,4-DIHYDROQUINOLIN-2(1H)-ONE Piperazine Formamide

Preparation Products

VESNARINONE Suppliers

Global( 89)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	10000	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471;	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39040	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	9922	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Shaanxi Dideu Medichem Co. Ltd	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Zibo Hangyu Biotechnology Development Co., Ltd	58

View Lastest Price from VESNARINONE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-05-20	Vesnarinone 81840-15-5	US $48.00-119.00 / mg		99.85%	10g	TargetMol Chemicals Inc.

Vesnarinone
81840-15-5
US $48.00-119.00 / mg
99.85%
TargetMol Chemicals Inc.

VESNARINONE Spectrum

VESNARINONE(81840-15-5)¹HNMR

81840-15-5(VESNARINONE)Related Search:

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(4-HYDROXY-PHENYL)-PIPERAZIN-1-YL-METHANONE ETHAMIVAN 1-(4-METHOXYBENZOYL)-PIPERAZINE VESNARINONE 1-[4-(4-AMINO-PHENYL)-PIPERAZIN-1-YL]-ETHANONE

6-AMINO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE 6''-AMINO-1,2,3,4-TETRAHYDROQUINOLINE 4-(4-BENZYLPIPERAZINO)ANILINE (3-METHOXY-PHENYL)-PIPERAZIN-1-YL-METHANONE 2-METHYL-4-(4-METHYLPIPERAZIN-1-YL)ANILINE

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VESNARINONE Arkin Piteranometozine OPC 8212 6-[4-(3,4-Dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro-2(1H)-quinolinone 2(1H)-Quinolinone, 6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro- 0PC-8212 3，4-Dihydro-6-[4-(3，4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone Vesnarinone(OPC8212) OPC8212;OPC 8212;OPC-8212 CS-2139 6-[4-(3,4-dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one VESNARINONE USP/EP/BP OPC8212,phosphodiesterase 3,Inhibitor,OSC5,OPC 8212,oral activity,OSC4,OSC3,positive inotropic activity,Vesnarinone,heart failure,inhibit,Phosphodiesterase (PDE) 6-(4-(3,4-Dimethoxybenzoyl)piperazin-1-yl)-3,4-dihydroquinolin-2(1H)-one Vesnarinone, 10 mM in DMSO 81840-15-5