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VESNARINONE

VESNARINONE structure

CAS No.: 81840-15-5

Chemical Name:: VESNARINONE

Synonyms: OPC 8212;Arkin;CS-2139;0PC-8212;VESNARINONE;Piteranometozine;Vesnarinone(OPC8212);VESNARINONE USP/EP/BP;OPC8212;OPC 8212;OPC-8212;Vesnarinone, 10 mM in DMSO

CBNumber:: CB6750484

Molecular Formula:: C22H25N3O4

Molecular Weight:: 395.45

MDL Number:: MFCD00867124

MOL File:: 81840-15-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:48:25

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VESNARINONE Properties

Melting point	238.1-239.5° (Tominaga); mp 238.1-239.8° (Shimizu)
Boiling point	519.41°C (rough estimate)
Density	1.2414 (rough estimate)
refractive index	1.6500 (estimate)
storage temp.	Store at -20°C
solubility	DMSO:9.84(Max Conc. mg/mL);24.88(Max Conc. mM) DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.26(Max Conc. mM) DMF:3.0(Max Conc. mg/mL);7.59(Max Conc. mM)
form	A crystalline solid
pka	2.86(at 25℃)
color	White to off-white
FDA UNII	5COW40EV8M

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

NFPA 704

	0
3		0

VESNARINONE price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	23489	Vesnarinone ≥98%	81840-15-5	1mg	$36	2026-04-30	Buy
Cayman Chemical	23489	Vesnarinone ≥98%	81840-15-5	5mg	$153	2026-04-30	Buy
Cayman Chemical	23489	Vesnarinone ≥98%	81840-15-5	10mg	$268	2026-04-30	Buy
Cayman Chemical	23489	Vesnarinone ≥98%	81840-15-5	25mg	$587	2026-04-30	Buy
ChemScene	CS-5387	Vesnarinone 98.52%	81840-15-5	5mg	$108	2026-06-04	Buy

Product number	Packaging	Price	Buy
23489	1mg	$36	Buy
23489	5mg	$153	Buy
23489	10mg	$268	Buy
23489	25mg	$587	Buy
CS-5387	5mg	$108	Buy

VESNARINONE Chemical Properties, Uses, Production

Description

Vesnarinone is a new orally-active positive inotropic agent introduced for the treatment of congestive heart failure. It exerts a positive inotropic effect on the heart and has a peripheral vasodilatory effect. Vesnarinone is claimed not to affect heart rate or aggravate arrhythmia.

Description

Vesnarinone is an inhibitor of phosphodiesterase 3 (PDE3; IC₅₀s = 10.7 and 13.2 μM for PDE3A and PDE3B, respectively). It also inhibits ether-a-go-go-related gene 1 (ERG1) channels (IC₅₀ = 1.1 μM in HEK293T cells expressing human ERG1). Vesnarinone (3-300 μM) increases contractile tension in isolated ventricular muscles of dog, cat, rabbit, and guinea pig in a dose-dependent manner. Oral and i.v. administration of vesnarinone increases right ventricular pressure with no effect on heart rate in dog models of tricuspid insufficiency- and pulmonary stenosis-induced congestive heart failure. It also increases contractility and coronary flow while decreasing heart rate in a guinea pig model of aortic stenosis-induced congestive heart failure. Formulations containing vesnarinone have been used for the treatment of congestive heart failure.

Chemical Properties

Colorless granular crystals from ethanol-chloroform, melting point 238.1-239.5°C; also odorless and tasteless light yellow crystalline powder, melting point 238.1-239.8°C. UV maximum absorption (methanol, ethanol, chloroform): 271 nm (ε25100, 25200, 23000, C=10μg/m1). Solubility % (25°C): glacial acetic acid 18.68, chloroform 14.19, benzyl alcohol 5.913, N-methyl-2-pyrrolidone 3.407, dimethyl sulfoxide 2.509, cyclobutanesulfone 1.229, dimethylformamide 1.179, dioxane 0.1653, methanol 0.1151, acetone 0.06389, ethanol 0.04005, water 0.002086. pKa 2.86.

Originator

Otsuka (Japan)

Uses

Cardiotonic.

Definition

ChEBI: Arkin (TN) is an organic molecular entity.

brand name

Arkin (Otsuka America);Arkin-Z.

References

[1] MOHSEN NIKPOUR . Design, synthesis and biological evaluation of 6-(benzyloxy)-4-methylquinolin-2(1H)-one derivatives as PDE3 inhibitors[J]. Bioorganic & Medicinal Chemistry, 2010, 18 2: Pages 855-862. DOI: 10.1016/j.bmc.2009.11.044
[2] Y KATAYAMA. Inhibitory effects of vesnarinone on cloned cardiac delayed rectifier K(+) channels expressed in a mammalian cell line.[J]. Journal of Pharmacology and Experimental Therapeutics, 2000, 294 1: 339-346.
[3] FELDMAN A M. Pharmacologic Properties and Clinical Evaluation of the New Inotropic Agent OPC-8212 (Vesnarinone)[J]. Cardiovascular Therapeutics, 1993, 11 1: 1-11. DOI: 10.1111/j.1527-3466.1993.tb00264.x
[4] MD S E R, FACC James B Y M Richard Holubkov PhD, FACC Jay N C M B G White PhD, et al. Estrogen is associated with improved survival in aging women with congestive heart failure: analysis of the vesnarinone studies[J]. Journal of the American College of Cardiology, 2000, 36 2: Pages 529-533. DOI: 10.1016/s0735-1097(00)00738-5

VESNARINONE Preparation Products And Raw materials

Raw materials

4-Methylanisole 3,4-Dihydroquinolin-2(1H)-one Piperazine Formamide

Preparation Products

VESNARINONE Suppliers

Global Suppliers ( 90)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2915	55
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2110	70
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7545	61
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4853	58
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Zhengzhou Saifun Biotechnology Co., Ltd.	022-60688926		China	60	55
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
ShangHai Biochempartner Co.,Ltd	177-54423994 17754423994	2853530910@QQ.com	China	8000	62
Shanghai Rechem science Co., Ltd.	021-31433387 15618786686	sales@rechemscience.com	China	2970	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58

Supplier	Advantage
Shanghai Boyle Chemical Co., Ltd.	55
LGM Pharma	70
Haoyuan Chemexpress Co., Ltd.	61
MedChemexpress LLC	58
Bide Pharmatech Ltd.	60
Zhengzhou Saifun Biotechnology Co., Ltd.	55
Shanghai YuanYe Biotechnology Co., Ltd.	60
ShangHai Biochempartner Co.,Ltd	62
Shanghai Rechem science Co., Ltd.	58
Amadis Chemical Company Limited	58

View Latest Price from VESNARINONE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-05-20	Vesnarinone 81840-15-5	$48.00-119.00		99.85%	10g	TargetMol Chemicals Inc.

Vesnarinone
81840-15-5
$48.00-119.00
99.85%
TargetMol Chemicals Inc.

VESNARINONE Spectrum

VESNARINONE(81840-15-5)¹HNMR

81840-15-5 (VESNARINONE) Related Search:

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VESNARINONE Arkin Piteranometozine 6-[4-(3,4-Dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro-2(1H)-quinolinone 2(1H)-Quinolinone, 6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro- 0PC-8212 3，4-Dihydro-6-[4-(3，4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone Vesnarinone(OPC8212) OPC8212;OPC 8212;OPC-8212 CS-2139 6-[4-(3,4-dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one VESNARINONE USP/EP/BP OPC8212,phosphodiesterase 3,Inhibitor,OSC5,OPC 8212,oral activity,OSC4,OSC3,positive inotropic activity,Vesnarinone,heart failure,inhibit,Phosphodiesterase (PDE) 6-(4-(3,4-Dimethoxybenzoyl)piperazin-1-yl)-3,4-dihydroquinolin-2(1H)-one Vesnarinone, 10 mM in DMSO OPC 8212 81840-15-5