(+/-)-Benzyloxycarbonyl-alpha-phosphonoglycine trimethyl ester
- CAS No.
- 88568-95-0
- Chemical Name:
- (+/-)-Benzyloxycarbonyl-alpha-phosphonoglycine trimethyl ester
- Synonyms
- Methyl 2-(((benzyloxy)carbonyl)aMino)-2-(diMethoxyphosphoryl)acetate;(±)-Z-α-Phosphonoglycine trimethyl ester;N-Benzylcarbonyl-alpha-phosphonoglycine trimethyl ester;(±)-Z-a-phosphonoglycine trimethyl ester;N-Cbz-2-Phosphonoglycine trimethyl ester;Benzyloxycarbonylamino-(dimethoxy-phosphoryl)-acetic acid methyl ester;Methyl 2-(((b;ycine trimethyL;)-Z-α-Phosphonog;)-Z-α-PhosphonogL
- CBNumber:
- CB9143207
- Molecular Formula:
- C13H18NO7P
- Molecular Weight:
- 331.26
- MDL Number:
- MFCD00043304
- MOL File:
- 88568-95-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 77-80 °C(lit.) |
|---|---|
| Boiling point | 480.5±45.0 °C(Predicted) |
| Density | 1.284±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Soluble in methanol. |
| pka | 9.42±0.46(Predicted) |
| form | Crystalline Powder |
| color | White |
| BRN | 5764460 |
| Major Application | peptide synthesis |
| InChI | InChI=1S/C13H18NO7P/c1-18-12(15)11(22(17,19-2)20-3)14-13(16)21-9-10-7-5-4-6-8-10/h4-8,11H,9H2,1-3H3,(H,14,16) |
| InChIKey | GSYSFVSGPABNNL-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)C(P(OC)(OC)=O)NC(OCC1=CC=CC=C1)=O |
| CAS DataBase Reference | 88568-95-0(CAS DataBase Reference) |
| UNSPSC Code | 12352209 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335-H302 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 22-24/25-36-26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29242990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
(+/-)-Benzyloxycarbonyl-alpha-phosphonoglycine trimethyl ester price More Price(94)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 376353 | Z-α-Phosphonoglycine trimethyl ester 97% | 88568-95-0 | 5g | $162 | 2026-04-30 | Buy |
| TCI Chemical | C2440 | N-Carbobenzoxy-2-phosphonoglycine Trimethyl Ester >98.0%(HPLC)(N) | 88568-95-0 | 1g | $46 | 2026-04-30 | Buy |
| TCI Chemical | C2440 | N-Carbobenzoxy-2-phosphonoglycine Trimethyl Ester >98.0%(HPLC)(N) | 88568-95-0 | 5g | $96 | 2026-04-30 | Buy |
| Usbiological | 262055 | (+/-)-Benzyloxycarbonyl-a-phosphonoglycine trimethylester Asreported | 88568-95-0 | 10g | $360 | 2026-06-03 | Buy |
| Usbiological | 262055 | (+/-)-Benzyloxycarbonyl-a-phosphonoglycine trimethylester Asreported | 88568-95-0 | 25g | $531 | 2026-06-03 | Buy |
(+/-)-Benzyloxycarbonyl-alpha-phosphonoglycine trimethyl ester Chemical Properties, Uses, Production
Preparation
A-phosphonoylglycine trimethyl ester was added to a round-bottom flask, and a 10% sodium carbonate aqueous solution was added and stirred to dissolve it. Then dioxane was added, and a 10% solution of 9-fluorenylmethoxycarbonyl chloride dioxane was slowly added dropwise to the reaction solution under ice bath conditions. After the addition was completed, the reaction was carried out in an ice bath for 2 hours, and then at room temperature for 8 hours. The solution was diluted with water and extracted 4 times with diethyl ether. The aqueous layer was placed in an ice bath, and the pH was adjusted with concentrated hydrochloric acid until Congo red paper turned blue. The solution was placed in a refrigerator overnight, and a white precipitate was obtained. The precipitate was extracted with ethyl acetate, and the combined organic liquids were washed with water. The organic layer was dried with anhydrous magnesium sulfate and then dried under vacuum to obtain (+/-)-BENZYLOXYCARBONYL-ALPHA-PHOSPHONOGLYCINE TRIMETHYL ESTER.
Description
(+/-)-Benzyloxycarbonyl-alpha-phosphonoglycine trimethyl ester is an important organic compound with the appearance of white to off-white powder to crystals, melting point of 78.0~ 82.0 °C, soluble in methanol, irritating to the eyes and skin, store in a cool, dry place in a closed Keep away from strong oxidising agents. Keep away from strong oxidising agents. It is mainly used in chemical industry and experimental research.
Chemical Properties
White crystalline powder
Uses
Starting material for the synthesis of (Z)-dehydroamino acids by Wittig-Horner reaction with aldehydes; the dehydroamino acids can be stereoselectively reduced to amino acids
Uses
Z-α-Phosphonoglycine is used in the synthesis of calcitonin gene-related peptide antagonists. Also used in the synthesis of dehydroamino acid esters for amino acid and peptide research.
reaction suitability
reaction type: solution phase peptide synthesis
(+/-)-Benzyloxycarbonyl-alpha-phosphonoglycine trimethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ITIC MEDCHEM(SUZHOU) CO.,LTD. | 0512-68323967 18015559028 | sales@iticmedchem.com | China | 528 | 61 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Shanghai Targsense Scientific Co., Ltd. | 18916626092 | targsense@qq.com | China | 110 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Suzhou Highfine Biotech Co., Ltd | 0512-69209928 18796809688 | zhouyingxiang@highfine.com | China | 472 | 75 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
View Latest Price from (+/-)-Benzyloxycarbonyl-alpha-phosphonoglycine trimethyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-07 | N-Cbz-2-Phosphonoglycine trimethyl ester
88568-95-0
|
1KG | 98% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2019-07-06 | (+/-)-BENZYLOXYCARBONYL-ALPHA-PHOSPHONOGLYCINE TRIMETHYL ESTER
88568-95-0
|
$100.00 | 1KG | 99% | Career Henan Chemical Co |
-
- N-Cbz-2-Phosphonoglycine trimethyl ester
88568-95-0
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- (+/-)-BENZYLOXYCARBONYL-ALPHA-PHOSPHONOGLYCINE TRIMETHYL ESTER
88568-95-0
- $100.00
- 99%
- Career Henan Chemical Co
88568-95-0 ((+/-)-Benzyloxycarbonyl-alpha-phosphonoglycine trimethyl ester) Related Search:
1of3
