2-Hydroxyethyl phosphonic acid
- CAS No.
- 22987-21-9
- Chemical Name:
- 2-Hydroxyethyl phosphonic acid
- Synonyms
- 2-Hydroxyethanephosphonic acid;BRN 1751212;Einecs 245-370-6;2-Hydroxyethyl phosphonic acid;(2-hydroxyethyl)-phosphonicaci;P-(2-Hydroxyethyl)-phosphonic Acid;Phosphonic acid, (2-hydroxyethyl)-;Phosphonic acid, P-(2-hydroxyethyl)-;2-Hydroxyethyl phosphonic acid, 97 %;Ethephon-hydroxy 100 μg/mL in Acetonitrile
- CBNumber:
- CB3137295
- Molecular Formula:
- C2H7O4P
- Molecular Weight:
- 126.05
- MDL Number:
- MFCD00043865
- MOL File:
- 22987-21-9.mol
- MSDS File:
- SDS
| Boiling point | 398.8±44.0 °C(Predicted) |
|---|---|
| Density | 1.611±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO (Sparingly), Methanol (Slightly) |
| form | Colourless to Red Thick Oil to Semi-Solid |
| pka | 2.25±0.10(Predicted) |
| Appearance | Colorless to light yellow Viscous Liquid |
| Stability | Hygroscopic |
| InChI | InChI=1S/C2H7O4P/c3-1-2-7(4,5)6/h3H,1-2H2,(H2,4,5,6) |
| InChIKey | SEHJHHHUIGULEI-UHFFFAOYSA-N |
| SMILES | P(CCO)(=O)(O)O |
| EWG's Food Scores | 1 |
| FDA UNII | 8A26D6AUP2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P405-P501 |
2-Hydroxyethyl phosphonic acid price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-H939650-25MG | 2-Hydroxyethanephosphonic Acid >95%(HPLC) | 22987-21-9 | 25mg | $271 | 2026-06-03 | Buy |
| TRC | TRC-H939650-250MG | 2-Hydroxyethanephosphonic Acid >95%(HPLC) | 22987-21-9 | 250mg | $1973 | 2026-06-03 | Buy |
| Biosynth | XAA98721 | 2-Hydroxyethylphosphonic acid | 22987-21-9 | 250mg | $360 | 2026-06-05 | Buy |
| Biosynth | XAA98721 | 2-Hydroxyethylphosphonic acid | 22987-21-9 | 2.5g | $1386.5 | 2026-06-05 | Buy |
| Matrix Scientific | 203687 | 2-Hydroxyethylphosphonic acid | 22987-21-9 | 1.00g | $794 | 2026-05-18 | Buy |
2-Hydroxyethyl phosphonic acid Chemical Properties, Uses, Production
Uses
2-Hydroxyethanephosphonic acid is an substrate used in the study of 2-hydroxyethylphosphonate dioxygenase reaction mechanism. 2-Hydroxyethanephosphonic Acid is also a required intermediate in labelled Fosfomycin (F727502) biosynthesis.
Definition
ChEBI: A phosphonic acid consisting of ethanol with the phospho group at the 2-position.
Synthesis
39118-50-8
22987-21-9
The general procedure for the synthesis of (2-hydroxyethyl)phosphonic acid from ethyl 2-(dimethoxyphosphono)acetate was as follows: to a 500 mL four-necked round-bottomed flask equipped with a heating jacket, thermocouples, a 10-pallet old Shore column and distillation head, were added sequentially dimethyl-2-(acetoxy)ethyl phosphonate (293 g, 1.5 mol), AMBERLYST-15 ion exchange resin (48 g) and water (72 g, 4 mol). The reaction mixture was heated to 100 °C. After 15 hours of reaction, the reaction temperature was raised to 105°C. During this process, the vapor temperature frequently reached 95 °C and the distillate was mainly water. Subsequently, about 150 g of additional water was added to the reaction system and the volatile components were removed under vacuum, resulting in 168 g (89% yield) of hydroxyethylphosphonic acid. The method avoids the use of stoichiometric HCl, thereby reducing the generation of corrosive and carcinogenic by-products (e.g., hydrochloric acid and methyl chloride), which are mainly methanol and methyl acetate, as compared to conventional methods. In addition, the method offers the advantage of easy recovery and reuse of the ion exchange resin.
References
[1] Patent: US2015/361117, 2015, A1. Location in patent: Paragraph 0009
[2] Phosphorus and Sulfur and the Related Elements, 1982, vol. 13, p. 363 - 370
2-Hydroxyethyl phosphonic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66028182 17714375163 | yftan@aikonchem.com | China | 16674 | 50 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4578 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4372 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
View Latest Price from 2-Hydroxyethyl phosphonic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 2-HYDROXYETHYL PHOSPHONIC ACID
22987-21-9
|
1KG | 98% | 1tone | Henan Aochuang Chemical Co.,Ltd. |
-
- 2-HYDROXYETHYL PHOSPHONIC ACID
22987-21-9
- 98%
- Henan Aochuang Chemical Co.,Ltd.
22987-21-9 (2-Hydroxyethyl phosphonic acid) Related Search:
1of4
