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(S)-1-Cbz-pyrrolidine-3-carboxylic acid

(S)-1-Cbz-pyrrolidine-3-carboxylic acid structure

CAS No.: 192214-00-9

Chemical Name:: (S)-1-Cbz-pyrrolidine-3-carboxylic acid

Synonyms: N-Cbz-S-3-Pyrrolidinecarboxylic acid;(S)-1-Cbz-3-pyrrolidinecarboxylic acid;(S)-1-Cbz-pyrrolidine-3-carboxylic acid;(S)-1-N-Cbz-Pyrrolidine-3-carboxylic acid;(S)-1-Cbz-pyrrolidine-3-carboxylic acid - [P12341];(3S)-1-benzyloxycarbonylpyrrolidine-3-carboxylic acid;1,3-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl) ester, (3S)-

CBNumber:: CB91500982

Molecular Formula:: C13H15NO4

Molecular Weight:: 249.26

MDL Number:: MFCD09608053

MOL File:: 192214-00-9.mol

MSDS File:: SDS

Last updated:2026-05-28 05:50:01

Product description	Number	Pack Size	Price
(S)-1-N-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID 97%	24146	1G	$43
(S)-1-N-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID 97%	24146	5G	$127
(S)-1-Cbz-pyrrolidine-3-carboxylic acid	124897	1.00g	$710
(S)-1-Cbz-pyrrolidine-3-carboxylic acid 95+%	P12341	1g	$86
(S)-1-Cbz-pyrrolidine-3-carboxylic acid 95+%	P12341	5g	$110
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(S)-1-Cbz-pyrrolidine-3-carboxylic acid Properties

Melting point	96-98 °C
Boiling point	432.3±45.0 °C(Predicted)
Density	1.309±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	4.46±0.20(Predicted)
Appearance	White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

(S)-1-Cbz-pyrrolidine-3-carboxylic acid price More Price(75)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AstaTech	24146	(S)-1-N-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID 97%	192214-00-9	1G	$43	2026-04-30	Buy
AstaTech	24146	(S)-1-N-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID 97%	192214-00-9	5G	$127	2026-04-30	Buy
Matrix Scientific	124897	(S)-1-Cbz-pyrrolidine-3-carboxylic acid	192214-00-9	1.00g	$710	2026-05-18	Buy
Synthonix	P12341	(S)-1-Cbz-pyrrolidine-3-carboxylic acid 95+%	192214-00-9	1g	$86	2026-05-06	Buy
Synthonix	P12341	(S)-1-Cbz-pyrrolidine-3-carboxylic acid 95+%	192214-00-9	5g	$110	2026-05-06	Buy

Product number	Packaging	Price	Buy
24146	1G	$43	Buy
24146	5G	$127	Buy
124897	1.00g	$710	Buy
P12341	1g	$86	Buy
P12341	5g	$110	Buy

(S)-1-Cbz-pyrrolidine-3-carboxylic acid Chemical Properties,Uses,Production

Synthesis

501-53-1

193693-69-5

192214-00-9

Step 1: To a 100 mL round bottom flask was added (S)-1-Cbz-3-pyrrolidinecarbonitrile (2 g, 8.7 mmol) and concentrated hydrochloric acid (20 mL). The mixture was refluxed for 4.5 h before the solvent was removed by vacuum distillation and dried overnight using an oil pump. The crude product was dissolved in a solvent mixture of acetone (20 mL) and deionized water (20 mL). After cooling to 0 °C, sodium carbonate (2.8 g, 26 mmol) was added, followed by slow dropwise addition of benzyl chloroformate (5.5 mL, 9.6 mmol). The reaction mixture was allowed to warm up gradually to room temperature. After 7 hours of reaction, the solvent was removed by vacuum distillation. Deionized water (8 mL) was added and extracted twice with a solvent mixture of hexane:EtOAc = 1:1. The aqueous layer was acidified to pH 2 by the addition of concentrated hydrochloric acid and 0.5 M potassium bisulfate.Subsequently, the aqueous layer was extracted with ethyl acetate (four times), and the organic phase was dried over sodium sulfate and concentrated by vacuum to afford (S)-1-CBZ-3-carboxypyrrolidine (1.46 g, 67% yield), which was used directly in the next step.1H NMR (CDCl3, 400 MHz): δ 7.38-7.29 (m, 5H), 5.14 (d, J = 2.8 Hz, 2H), 3.72-3.43 (m, 4H), 3.17-3.09 (m, 1H), 2.21-2.14 (m, 2H).

References

[1] Patent: WO2011/160020, 2011, A2. Location in patent: Page/Page column 62

(S)-1-Cbz-pyrrolidine-3-carboxylic acid synthesis

Synthesis of (S)-1-Cbz-pyrrolidine-3-carboxylic acid from (S)-Pyrrolidine-3-carboxylic acid and Benzyl chloroformate

(S)-1-Cbz-pyrrolidine-3-carboxylic acid Preparation Products And Raw materials

Raw materials

Pyrrolidine, 3-[(phenylmethoxy)methyl]-1-(phenylmethyl)-, (3S)- 1,4-Butanediol, 2-[(phenylmethoxy)methyl]-, (2S)- 2(3H)-Furanone, dihydro-4-[(phenylmethoxy)methyl]-, (4R)- (S)-1-BENZYL-BETA-PROLINOL (S)-1-N-Cbz-3-cyanopyrrolidine

(S)-1-CBZ-3-HYDROXYMETHYLPYRROLIDINE (S)-Pyrrolidine-3-carboxylic acid (R)-1-CBZ-3-PYRROLIDINOL (S)-Pyrrolidin-3-ylmethanol Benzyl chloroformate

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Preparation Products

1,3-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl)easter, (R)

(S)-1-Cbz-pyrrolidine-3-carboxylic acid Suppliers

Global( 90)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10403	58
HaBo Hong Kong Co., Limited.	+86-25-18512596065	info@habotech.com	CHINA	933	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15083	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52705	58
Hangzhou Huarong Pharm Co., Ltd.	571-86758373 +8613588754946	sales@huarongpharm.com	CHINA	3148	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Shenzhen Nexconn Pharmatechs Ltd	58
HaBo Hong Kong Co., Limited.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
AFINE CHEMICALS LIMITED	58
Hefei Hirisun Pharmatech Co., Ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Hangzhou Huarong Pharm Co., Ltd.	58

View Lastest Price from (S)-1-Cbz-pyrrolidine-3-carboxylic acid manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-13	(S)-1-Cbz-pyrrolidine-3-carboxylic acid 192214-00-9	$1.00	1g	99.0%	100kg	Career Henan Chemical Co

(S)-1-Cbz-pyrrolidine-3-carboxylic acid
192214-00-9
$1.00
99.0%
Career Henan Chemical Co

(S)-1-Cbz-pyrrolidine-3-carboxylic acid Spectrum

(S)-1-Cbz-pyrrolidine-3-carboxylic acid(192214-00-9)¹HNMR

192214-00-9((S)-1-Cbz-pyrrolidine-3-carboxylic acid)Related Search:

1,2,4-pyrrolidinetricarboxylic acid, 5-(5-oxazolyl)-2-(1H-pyrazol-1-ylmethyl)-, 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2R,4S,5R)- 1,2,4-pyrrolidinetricarboxylic acid, 2-(2-methylpropyl)-5-(5-oxazolyl)-, 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2S,4S,5R)- 1,2,4-pyrrolidinetricarboxylic acid, 2-(1H-pyrazol-1-ylmethyl)-5-(2-thienyl)-, 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2R,4S,5R)- (S)-1-Cbz-pyrrolidine-3-carboxylic acid 1,2,4-pyrrolidinetricarboxylic acid, 2-(1H-imidazol-1-ylmethyl)-5-(5-oxazolyl)-, 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2R,4S,5R)-

1,2,4-pyrrolidinetricarboxylic acid, 2-(1H-imidazol-1-ylmethyl)-5-(2-thienyl)-, 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2R,4S,5R)- 1,2,4-pyrrolidinetricarboxylic acid, 2-(1H-pyrazol-1-ylmethyl)-5-(5-thiazolyl)-, 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2R,4S,5R)- 1,2,4-pyrrolidinetricarboxylic acid, 2-(1H-imidazol-1-ylmethyl)-5-(5-thiazolyl)-, 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2R,4S,5R)- 1,2,4-pyrrolidinetricarboxylic acid, 2-(2-methylpropyl)-5-(2-thienyl)-, 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2S,4S,5R)- 1,2,4-pyrrolidinetricarboxylic acid, 2-(2-methylpropyl)-5-(5-thiazolyl)-, 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2S,4S,5R)-

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(S)-1-Cbz-pyrrolidine-3-carboxylic acid (S)-1-N-Cbz-Pyrrolidine-3-carboxylic acid 1,3-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl) ester, (3S)- (S)-1-Cbz-3-pyrrolidinecarboxylic acid N-Cbz-S-3-Pyrrolidinecarboxylic acid (3S)-1-benzyloxycarbonylpyrrolidine-3-carboxylic acid (S)-1-Cbz-pyrrolidine-3-carboxylic acid - [P12341] 192214-00-9 pharmacetical