ChemicalBook >> CAS DataBase List >>3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline structure

CAS No.: 641571-11-1

Chemical Name:: 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Synonyms: NILOTINIB IMPURITY 24;Nilotinib EP Impurity A;Nilotinib Intemediate 1;Nilotinib Amino Impurity;Nilotinib??Intermediates?A;Nilotinib Related Compound A;Nilotinib genotoxic impurity 1;Nilotinib Hydrochloride Monohydrate Impurity A;Nilotinib Impurity 15(Nilotinib EP Impurity A);3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)

CBNumber:: CB91503963

Molecular Formula:: C11H10F3N3

Molecular Weight:: 241.21

MDL Number:: MFCD11846236

MOL File:: 641571-11-1.mol

TDS File:: TDS

Last updated:2026-04-24 14:58:28

Product description	Number	Pack Size	Price
3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline	VBP00135	1g	$529
Nilotinib Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material	PHR2834	50 mg	$539
3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline >98.0%(GC)(T)	M2634	1g	$39
3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline >98.0%(GC)(T)	M2634	5g	$128
3-(4-Methyl-1H-imidazol-1-yl)-5-trifluoromethylaniline	M313065	25mg	$145
More product size

Request For Quotation

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Properties

Melting point	124-126°C
Boiling point	372.14℃[at 101 325 Pa]
Density	1.35
vapor pressure	0Pa at 25℃
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	powder to crystal
color	White to Light gray to Light yellow
Water Solubility	228.6mg/L at 25℃
InChI	InChI=1S/C11H10F3N3/c1-7-5-17(6-16-7)10-3-8(11(12,13)14)2-9(15)4-10/h2-6H,15H2,1H3
InChIKey	WWTGXYAJVXKEKL-UHFFFAOYSA-N
SMILES	C1(N2C=C(C)N=C2)C=C(N)C=C(C(F)(F)F)C=1
LogP	2.42
CAS DataBase Reference	641571-11-1(CAS DataBase Reference)
FDA UNII	5LLI0Q7APP
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05,GHS06
Signal word	Danger
Hazard statements	H301-H318
Precautionary statements	P280-P301+P310-P305+P351+P338
Risk Statements	41
Safety Statements	26-39
RIDADR	2811
WGK Germany	WGK 3
HazardClass	6.1
PackingGroup	Ⅲ
HS Code	2933299090
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	VBP00135	3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline	641571-11-1	1g	$529	2026-03-19	Buy
Sigma-Aldrich	PHR2834	Nilotinib Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material	641571-11-1	50 mg	$539	2026-03-19	Buy
TCI Chemical	M2634	3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline >98.0%(GC)(T)	641571-11-1	1g	$39	2026-03-19	Buy
TCI Chemical	M2634	3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline >98.0%(GC)(T)	641571-11-1	5g	$128	2026-03-19	Buy
TRC	M313065	3-(4-Methyl-1H-imidazol-1-yl)-5-trifluoromethylaniline	641571-11-1	25mg	$145	2021-12-16	Buy

Product number	Packaging	Price	Buy
VBP00135	1g	$529	Buy
PHR2834	50 mg	$539	Buy
M2634	1g	$39	Buy
M2634	5g	$128	Buy
M313065	25mg	$145	Buy

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Chemical Properties,Uses,Production

Description

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline is a pharmaceutical intermediate component used in the preparation of Nilotinib for the treatment of a variety of leukaemias, including chronic myeloid leukaemia (CML).

Chemical Properties

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline is a white to light grey to light yellow powder to crystals with a melting point of 130 °C.

Uses

Intermediate in the preparation of Nilotinib.

Application

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline is an arylimidazole derivative. This compound includes multiple functional groups: aniline, methyl, and imidazole. Hence, the compound is readily available for further functionalization. This building block can typically synthesize homoleptic imidazole-type iridium (Ir) triplet emitters as a blue phosphorescent emitter in OLED. The iridium organometallic complex is formed by coordinating the imidazole and the aryl group to the iridium metal center. The trifluoromethyl group, with a strong electron-withdrawing effect, increases the energy gap between the highest occupied molecular orbital and the lowest unoccupied molecular orbital (HOMO-LUMO), hence enabling a blue shift in the photoluminescent emission[1].

References

[1] Qiang Wei. “Small-Molecule Emitters with High Quantum Efficiency: Mechanisms, Structures, and Applications in OLED Devices.” Advanced Optical Materials 6 20 (2018).

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline synthesis

Synthesis of 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline from 4-Methylimidazole and 3-Amino-5-bromobenzotrifluoride

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Preparation Products And Raw materials

Raw materials

Benzenamine, 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)-, hydrochloride (1:1) Benzenamine, 3-iodo-5-(trifluoromethyl)- 3-(4-Methylimidazol-1-yl)-5-trifluoromethylbenzoic acid 3-Amino-5-bromobenzotrifluoride 1H-IMidazole, 4-Methyl-1-[3-nitro-5-(trifluoroMethyl)phenyl]-

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzamide 3-FLUORO-5-NITROBENZOTRIFLUORIDE 3-Amino-5-fluorobenzotrifluoride 4-Methylimidazole Benzotrifluoride

1of2

Preparation Products

3-Iodo-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamide Nilotinib

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Suppliers

Global( 383)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Yangzhou Qinyuan Pharmatech Co.,ltd	+86-18752526868 +86-18752526868	jennysun@yzqyyykj.com	China	80	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Shandong Jihui Chemical Co., Ltd.	+8615053042019	sales@jihuichem.com	China	34	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13843	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21591	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	340	58

Supplier	Advantage
Yangzhou Qinyuan Pharmatech Co.,ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Shandong Jihui Chemical Co., Ltd.	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Yingrui Biopharma Co., Ltd.	60
Anqing Chico Pharmaceutical Co., Ltd.	58

View Lastest Price from 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-02-28	3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline 641571-11-1	US $0.00-0.00 / kg	1kg	Purity: 99%	500tons	Shandong Jihui Chemical Co., Ltd.
2025-11-18	3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline 641571-11-1	US $1.10 / g	1g	99.0% Min	100 Tons	Dideu Industries Group Limited
2025-09-25	3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline 641571-11-1	US $35.00-1.20 / kg	1kg	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1
US $0.00-0.00 / kg
Purity: 99%
Shandong Jihui Chemical Co., Ltd.

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1
US $1.10 / g
99.0% Min
Dideu Industries Group Limited

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
641571-11-1
US $35.00-1.20 / kg
99%
Henan Fengda Chemical Co., Ltd

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Spectrum

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline(641571-11-1)¹HNMR

641571-11-1(3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline)Related Search:

Acid Blue 93 o-Toluidine Bensulfuron methyl Aniline N-Methylaniline

N,N-Dimethyl-1,4-phenylenediamine Methyl cellulose 1-Methylimidazole 3-Amino-5-bromobenzotrifluoride N,N-Dimethylaniline

Methyl acrylate Methylparaben METSULFURON METHYL 3,3',5,5'-Tetramethylbenzidine dihydrochloride Tris(hydroxymethyl)aminomethane

Glycine Aminoethoxyvinyl glycine hydrochloride Nilotinib N-Oxide

1of4

1-(3-Amino-5-trifluoromethylphenyl)-4-methylimidazole 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline 3-(4-Methyl-1-imidazolyl)-5-(trifluoromethyl)aniline Nilotinib EP Impurity A NILOTINIB IMPURITY 24 4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl) benzene amine 3-(trifluoromethyl)-5-(4-methyl-1H-imidazol-1-yl)benzenamine 3-(4-Methyl-iMidazol-1-yl)-5-trifluoro-MethylphenylaMine 3-Amino-5-(4-methyl-1H-imidazol-1-yl)benzotrifluoride 3-(4-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)benzenaMine 3-(4-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)benzeneaMine, 3-(4-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)aniline BenzenaMine, 3-(4-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)- 3-(4-Methyl-iMidazole-1-yl)-5-trifluoro MethylphenylaMine 5-(4-Methyl-1H-iMidazol-1-yl)-3-(trifluoroMethyl)-BenzeneaMine 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline 1-(3-Amino-5-trifluoromethylphenyl)-4-methylimidazole Nilotinib genotoxic impurity 1 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Nilotinib Intemediate 1 Nilotinib Amino Impurity 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline > Nilotinib Related Compound A USP Impurity Certified Reference Standard 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoro methyl)benzamine 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl) 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline(For export only) 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline ISO 9001：2015 REACH 3-(4-Methyl-1H-imidazol-1-yl)-5- (trifluoromethyl)aniline(Nilotinib EP Impurity A) Nilotinib??Intermediates?A Nilotinib Hydrochloride Monohydrate EP Impurity A 5-(4-Methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)benzenamine 3-(4-Methyl-1H-Imidazol-1-yl)-5-(Tri?uoromethyl)Aniline 5-(4-Methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-aniline 5- (4-methyl-1H-Imidazol-1-yl)3- (trifluoromethy benzenamine Nilotinib Hydrochloride Monohydrate Impurity A Nilotinib Impurity 15(Nilotinib EP Impurity A) Nilotinib Related Compound A Nilotinib Impurity 24 Nilotinib EP Impurity A (Nilotinib USP Related Compound A) Nilotinib EP Impurity A (Nilotinib USP Related Compound A) 641571-11-1 541571-11-1 Nilotinib/Tasigna Amines Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals