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N-Boc-5-aminolevulinic acid

N-Boc-5-aminolevulinic acid Structure
N-Boc-5-aminolevulinic acid structure
CAS No.
72072-06-1
Chemical Name:
N-Boc-5-aminolevulinic acid
Synonyms
N-Boc-5-aminolevulinic acid;5-(Boc-amino)-4-oxo-pentanoic acid;5-(Tert-butoxycarbonylamino)-4-oxopentanoic acid;Pentanoic acid,5-[[(1,1-dimethylethoxy)carbonyl]amino]-4-oxo-;5-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)-4-oxopentanoic acid
CBNumber:
CB91562166
Molecular Formula:
C10H17NO5
Molecular Weight:
231.25
MDL Number:
MFCD02682635
MOL File:
72072-06-1.mol
MSDS File:
SDS
Last updated:2026-05-28 04:25:49
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N-Boc-5-aminolevulinic acid Properties

Boiling point 401.5±25.0 °C(Predicted)
Density 1.169±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka 4.61±0.17(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H319
Precautionary statements  P305+P351+P338

N-Boc-5-aminolevulinic acid price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 303852 5-((tert-Butoxycarbonyl)amino)-4-oxopentanoic acid 72072-06-1 100.00mg $58 2026-05-19 Buy
Matrix Scientific 303852 5-((tert-Butoxycarbonyl)amino)-4-oxopentanoic acid 72072-06-1 250.00mg $91 2026-05-19 Buy
Matrix Scientific 303852 5-((tert-Butoxycarbonyl)amino)-4-oxopentanoic acid 72072-06-1 1.00g $226 2026-05-19 Buy
Synthonix B53242 5-((tert-Butoxycarbonyl)amino)-4-oxopentanoic acid 95+% 72072-06-1 100mg $60 2026-05-06 Buy
Synthonix B53242 5-((tert-Butoxycarbonyl)amino)-4-oxopentanoic acid 95+% 72072-06-1 250mg $100 2026-05-06 Buy
Product number Packaging Price Buy
303852 100.00mg $58 Buy
303852 250.00mg $91 Buy
303852 1.00g $226 Buy
B53242 100mg $60 Buy
B53242 250mg $100 Buy

N-Boc-5-aminolevulinic acid Chemical Properties, Uses, Production

Synthesis

Di-tert-butyl dicarbonate

24424-99-5

5-Aminolevulinic acid hydrochloride

5451-09-2

N-Boc-5-aminolevulinic acid

72072-06-1

A suspension was prepared from 5-aminolevulinic acid hydrochloride (2) (5.00 g, 29.8 mmol), NaHCO3 (15.04 g, 179.0 mmol) and di-tert-butyl dicarbonate (6.51 g, 29.8 mmol) in anhydrous methanol and the reaction was stirred at room temperature overnight. Upon completion of the reaction, the insoluble solids were removed by filtration followed by evaporation to remove the solvent. The oily residue obtained was dissolved in water and the pH of the aqueous phase was adjusted with 10% aqueous KHSO4 to 2. The mixture was extracted with ethyl acetate (EtOAc), the organic phase was washed with saturated saline, dried over anhydrous Na2SO4, filtered and concentrated. The oily residue was purified by silica gel column chromatography (eluent ratio CH2Cl2/MeOH = 10/1) to afford the target product 5-((tert-butoxycarbonyl)amino)-4-oxopentanoic acid (3) (6.24 g, 90% yield) as a white solid with a melting point of 72-74°C (literature value 74-77°C). The spectral data of product 3 were in agreement with literature reports.

References

[1] Arkivoc, 2014, vol. 2014, # 3, p. 228 - 238
[2] Journal of Medicinal Chemistry, 2008, vol. 51, # 23, p. 7356 - 7369
[3] Photochemistry and Photobiology, 2003, vol. 78, # 5, p. 481 - 486

N-Boc-5-aminolevulinic acid Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate 5-Aminolevulinic acid hydrochloride Sodium bicarbonate Methanol

Preparation Products

N-Boc-5-aminolevulinic acid Suppliers

Global Suppliers ( 32)
Supplier Tel Email Country ProdList Advantage
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Shanghai Raise Chemical Technology Co.,Ltd 15026594951 rs@raise-chem.com China 4904 55
Shanghai Balmxy Pharmaceutical Co., Ltd 021-24206007 13764915196 sales@balmxy.com China 6959 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Amatek Scientific Co. Ltd. 0512-56316828 400-867-5858;400-867-5858 info@amateksci.com China 28760 58
Hangzhou Molcore Biopharmatech Co.,Ltd 400-711-5280 86-571-81025280 sales@molcore.com China 9957 58
Capot Chemical Co.,Ltd. +86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Aikon International Limited 025-58851090 13913916777 sales01@aikonchem.com China 15947 58
Supplier Advantage
Energy Chemical 61
Capot Chemical Co., Ltd 66
Shanghai Raise Chemical Technology Co.,Ltd 55
Shanghai Balmxy Pharmaceutical Co., Ltd 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
Amadis Chemical Company Limited 58
Amatek Scientific Co. Ltd. 58
Hangzhou Molcore Biopharmatech Co.,Ltd 58
Capot Chemical Co.,Ltd. 60
Aikon International Limited 58

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N-Boc-5-aminolevulinic acid 5-(Tert-butoxycarbonylamino)-4-oxopentanoic acid 5-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)-4-oxopentanoic acid Pentanoic acid,5-[[(1,1-dimethylethoxy)carbonyl]amino]-4-oxo- 5-(Boc-amino)-4-oxo-pentanoic acid 72072-06-1