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N-Boc-4-oxo-L-Proline methyl ester

N-Boc-4-oxo-L-Proline methyl ester structure

CAS No.: 102195-80-2

Chemical Name:: N-Boc-4-oxo-L-Proline methyl ester

Synonyms: 1-(tert-butyl) 2-methyl (S)-4-oxopyrrolidine-1,2-dicarboxylate;(S)-1-tert-Butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate;Methyl N-Boc-4-keto-prolinate;N-Boc-4-oxo-L;CAS:102195-80-2;BOC-4-OXO-PRO-OME;BOC-L-PRO(4-O)-OME;BOC-L-PRO(4-OXO)-OME;BOC-PRO-(4-KETO)-OME;Boc-L-Pro(4-keto)-OMe

CBNumber:: CB3398551

Molecular Formula:: C11H17NO5

Molecular Weight:: 243.26

MDL Number:: MFCD01861778

MOL File:: 102195-80-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 06:25:22

Product description	Number	Pack Size	Price
N-Boc-4-oxo-L-proline methyl ester 97%	702498	1g	$88.1
(2S)-1-Boc-4-oxo-proline methyl ester	262880	1g	$333
(2S)-1-Boc-4-oxo-proline methyl ester	262880	2g	$475
(2S)-1-Boc-4-oxo-proline methyl ester	262880	5g	$729
(2S)-1-Boc-4-oxo-proline methyl ester	262880	10g	$970
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N-Boc-4-oxo-L-Proline methyl ester Properties

Melting point	35-40°C
alpha	14 º (C=1 IN CHLOROFORM)
Boiling point	333.1±42.0 °C(Predicted)
Density	1.209±0.06 g/cm3(Predicted)
Flash point	110 °C
storage temp.	-20°C
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	Powder
pka	-3.86±0.40(Predicted)
Appearance	Light yellow to brown Solid
optical activity	[α]22/D +14.0°, c = 1 in chloroform
InChI	InChI=1S/C11H17NO5/c1-11(2,3)17-10(15)12-6-7(13)5-8(12)9(14)16-4/h8H,5-6H2,1-4H3/t8-/m0/s1
InChIKey	UPBHYYJZVWZCOZ-QMMMGPOBSA-N
SMILES	N1(C(OC(C)(C)C)=O)CC(=O)C[C@H]1C(OC)=O
CAS DataBase Reference	102195-80-2(CAS DataBase Reference)
UNSPSC Code	12352005
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302+H312-H318

Precautionary statements

P280-P301+P312+P330-P302+P352+P312-P305+P351+P338+P310

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

20/21/22-41

Safety Statements

26-36/37-39

WGK Germany

HazardClass

IRRITANT

HS Code

29339900

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Dermal
Acute Tox. 4 Oral
Eye Dam. 1

NFPA 704

	1
2		0

N-Boc-4-oxo-L-Proline methyl ester price More Price(84)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	702498	N-Boc-4-oxo-L-proline methyl ester 97%	102195-80-2	1g	$88.1	2026-04-30	Buy
Usbiological	262880	(2S)-1-Boc-4-oxo-proline methyl ester	102195-80-2	1g	$333	2026-06-03	Buy
Usbiological	262880	(2S)-1-Boc-4-oxo-proline methyl ester	102195-80-2	2g	$475	2026-06-03	Buy
Usbiological	262880	(2S)-1-Boc-4-oxo-proline methyl ester	102195-80-2	5g	$729	2026-06-03	Buy
Usbiological	262880	(2S)-1-Boc-4-oxo-proline methyl ester	102195-80-2	10g	$970	2026-06-03	Buy

Product number	Packaging	Price	Buy
702498	1g	$88.1	Buy
262880	1g	$333	Buy
262880	2g	$475	Buy
262880	5g	$729	Buy
262880	10g	$970	Buy

N-Boc-4-oxo-L-Proline methyl ester Chemical Properties,Uses,Production

Chemical Properties

Yellow Solid

Uses

(2S)-1-Boc-4-oxo-proline Methyl Ester (cas# 102195-80-2) is a compound useful in organic synthesis.

Synthesis

N-Boc-trans-4-Hydroxy-L-proline methyl ester

74844-91-0

102195-80-2

General procedure for the synthesis of BOC-4-oxo-L-proline methyl ester from N-Boc-trans-4-hydroxy-L-proline methyl ester: (a) To a solution of methyl (2S,4R)-1-Boc-4-hydroxypyrrolidine-2-carboxylate (40 g, 157 mmol) in dichloromethane (DCM, 500 mL) was added Days-Martin oxidizer (DMP, 80 g, 189 mmol) at 0 °C. The reaction mixture was stirred at room temperature for 4 h. Upon completion of the reaction, the reaction was quenched with sodium bisulfite (NaHSO3) solution. The reaction mixture was extracted with dichloromethane (DCM) and the organic phase was washed with aqueous sodium bicarbonate (NaHCO3) solution. Concentration of the organic phase afforded the title intermediate (2S)-1-tert-butoxycarbonyl-4-oxopyrrolidine-2-carboxylic acid methyl ester (33 g, 89% yield) as a colorless oil. 1H NMR (400 MHz, CDCl3): δ (ppm) 1.51 (s, 9H), 2.550-2.597 (d, 1H, J = 18.8Hz), 2.876-2.944 (t, 1H, J = 13.6Hz), 3.895 (s, 3H), 3.766-3.895 (m, 1H), 4.696- 4.814 (m, 1H).

References

[1] Chemical and Pharmaceutical Bulletin, 2000, vol. 48, # 5, p. 740 - 742
[2] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 4, p. 1557 - 1572
[3] Journal of the American Chemical Society, 2016, vol. 138, # 7, p. 2443 - 2453
[4] Angewandte Chemie - International Edition, 2002, vol. 41, # 9, p. 1600 - 1602
[5] Tetrahedron Letters, 2003, vol. 44, # 42, p. 7809 - 7812

N-Boc-4-oxo-L-Proline methyl ester synthesis

Synthesis of N-Boc-4-oxo-L-Proline methyl ester from N-Boc-trans-4-Hydroxy-L-proline methyl ester

N-Boc-4-oxo-L-Proline methyl ester Preparation Products And Raw materials

Raw materials

(2S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate N-Boc-4-oxo-L-proline N-Boc-trans-4-Hydroxy-L-proline methyl ester 1-(TERT-BUTOXYCARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID trans-4-Hydroxy-L-proline methyl ester hydrochloride

Boc-Hyp-OH (2S,4R)-Methyl 4-hydroxypyrrolidine-2-carboxylate Di-tert-butyl dicarbonate Dimethyl sulfoxide 4-Methylmorpholine N-oxide

L-Hydroxyproline Oxalyl chloride

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Preparation Products

(S)-N-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide

N-Boc-4-oxo-L-Proline methyl ester Suppliers

Global( 298)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21533	55
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
career henan chemical co	+86-0371-86658258	factory@coreychem.com	China	29780	58
Fuxin Pharmaceutical	+86-021-021-50872116	contact@fuxinpharm.com	China	9976	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759	marketing1@neostarunited.com	China	8827	58
Career Henan Chemica Co	+86-0371-86658258 +86-13203830695	laboratory@coreychem.com	China	30203	58
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14301	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1059@dideu.com	China	29096	58
Finetech Industry Limited	+86-27-8746-5837 +86-18627785180	info@finetechnology-ind.com	China	9539	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Fuxin Pharmaceutical	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
Career Henan Chemica Co	58
Win-Win chemical CO., Limited	58
Dideu Industries Group Limited	58
Finetech Industry Limited	58

View Lastest Price from N-Boc-4-oxo-L-Proline methyl ester manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-06-30	N-Boc-4-oxo-L-Proline methyl ester 102195-80-2		1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
	2020-01-17	BOC-4-OXO-PRO-OME 102195-80-2	$3.00	1KG	98%	1kg,5kg,50kg	Career Henan Chemical Co

N-Boc-4-oxo-L-Proline methyl ester
102195-80-2
$0.00
99%
Shaanxi Dideu New Materials Co. Ltd

BOC-4-OXO-PRO-OME
102195-80-2
$3.00
98%
Career Henan Chemical Co

N-Boc-4-oxo-L-Proline methyl ester Spectrum

BOC-4-OXO-PRO-OME(102195-80-2)¹HNMR

102195-80-2(N-Boc-4-oxo-L-Proline methyl ester)Related Search:

BOC-DL-PRO-OH Methyl N-(tert-butoxycarbonyl)-L-threoninate BOC-TRP(BOC)-OH Boc-Tyr-OtBu Boc-D-Ser(tBu)-OH

L-Hydroxyproline L-Proline BOC-SER(TOS)-OCH3 L-Phenylalanine BOC-D-TYR(TBU)-OH

N-Boc-trans-4-amino-L-proline methyl ester hydrochloride BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER N-Boc-4-oxo-L-proline 4-OXO-PROLINE N-Boc-4-oxo-L-Proline methyl ester

BOC-L-PRO(4-OXO)-O-BN (2S, 4R)-4-AMINO-1-[T-BUTOXYCARBONYL]PYRROLIDINE-2-ETHYLCARBOXYLATE (2S,4R)-4-AMINO-1-BOC-PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER-OXYLATE SALT

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Boc-L-Pro(4-keto)-OMe N-alpha-t-Butyloxycarbonyl-4-oxo-L-proline methyl ester BOC-PRO-(4-KETO)-OME BOC-4-OXO-PRO-OME BOC-4-OXO-L-PROLINE METHYL ESTER BOC-GAMMA-KETO-L-PROLINE METHYL ESTER BOC-L-PRO(4-O)-OME BOC-L-PRO(4-OXO)-OME (S)-N-ALPHA-TERT-BUTYLOXYCARBONYL-4-OXO-PROLINE METHYL ESTER N-T-BOC-4-OXO-L-PROLINE METHYL ESTER N-BOC-4-OXO-L-PROLINE METHYL ESTER METHYL (2S)-N-BOC-4-OXOPYRROLIDINE-2-CARBOXYLATE (S)-1-tert-Butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate (2S)-4-Oxo-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid methyl ester 1-BOC-4-OXO-L-PROLINE METHYL ESTER N-tert-butyloxycarbonyl-4-oxo-L-proline methyl ester tert-Butyl (2S)-2-(methoxycarbonyl)-4-oxopyrrolidine-1-carboxylate, (2S)-4-Oxo-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid methyl ester, 1-tert-Butyl 2-methyl (2S)-4-oxopyrrolidine-1,2-dicarboxylate 1-tert-Butyl 2-methyl(2S)-4-oxopyrrolidine-1,2-dicarboxylate tert-Butyl(2S)-2-(methoxycarbonyl)-4-oxopyrrolidine-1-carboxylate (2S)-4-Oxo-1,2-pyrrolidinedicarboxylic Acid 1-(1,1-DiMethylethyl) 2-Methyl Ester (2S)-4-Oxopyrrolidine-1,2-dicarboxylate 1,2-Pyrrolidinedicarboxylicacid, 4-oxo-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2S)- (2S)-1-Boc-4-o×o-proline Methyl Ester (S)-1-tert-butyl 2-Methyl 4-o×opyrrolidine-1,2-dicarbo×ylate (2S)-1-(tert-Butoxycarbonyl)-2-(methoxycarbonyl)-4-oxopyrrolidine, 4-Oxo-L-proline methyl ester, N-BOC protected Methyl (2S)-1-Boc-4-oxo-pyrrolidinecarboxylate (Tert-Butoxy)Carbonyl 4-oxo-Pro-OMe 1-tert-Butyl 2-methyl (2S)-4-oxopyrrolidine-1,2-dicarboxylate 97% N-Boc-4-oxo-L Boc-4-OXO-Pro-OMe (non-animal) BOC-4-OXO-PRO-OME USP/EP/BP N-Boc-4-oxo-L-proline methyl esterQ: What is N-Boc-4-oxo-L-proline methyl ester Q: What is the CAS Number of N-Boc-4-oxo-L-proline methyl ester 102195-80-2 BOC-4-OXO-PRO-OME (2S)-N-Boc-4-oxo-L-proline methyl ester (S)-tert-Butyl 2-(methoxycarbonyl)-4-oxopyrrolidine-1-carboxylate 1-(1,1-Dimethylethyl) 2-methyl (2S)-4-oxo-1,2-pyrrolidinedicarboxylate 1-(tert-Butyl) 2-methyl (2S)-4-oxo-1,2-pyrrolidinedicarboxylate CAS:102195-80-2 N-Boc-4-oxo-L-proline methyl ester 1-(tert-butyl) 2-methyl (S)-4-oxopyrrolidine-1,2-dicarboxylate Methyl N-Boc-4-keto-prolinate 102195-80-2 Boc-Amino Acids and Derivative Boc-Amino acid series Amino Acids Amino Acids & Derivatives Heterocycles