Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>4-(HYDROXYMETHYL)BENZONITRILE

4-(HYDROXYMETHYL)BENZONITRILE

4-(HYDROXYMETHYL)BENZONITRILE Structure
4-(HYDROXYMETHYL)BENZONITRILE structure
CAS No.
874-89-5
Chemical Name:
4-(HYDROXYMETHYL)BENZONITRILE
Synonyms
4-cyanobeznyl alcohol;4-CYANOBENZYL ALCOHOL;4-methylolbenzonitrile;4-Cyanobenzenemethanol;Tranexamic Acid Impurity 13;4-(HYDROXYMETHYL)BENZONITRILE;Benzonitrile,4-(hydroxyMethyl)-;4-(Hydroxymethyl)benzonitrile 95%;4-(hydroxymethyl)benzenecarbonitrile;4-((N-nitrosoacetamido)methyl)benzoic acid
CBNumber:
CB9184327
Molecular Formula:
C8H7NO
Molecular Weight:
133.15
MDL Number:
MFCD00870633
MOL File:
874-89-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:23:09
Product description Number Pack Size Price
4-(Hydroxymethyl)benzonitrile 95% 527750 10g $452
4-Cyanobenzyl alcohol FC70532 25g $329.25
4-Cyanobenzyl alcohol FC70532 50g $595
4-Cyanobenzyl alcohol FC70532 100g $1006
4-Cyanobenzyl alcohol FC70532 250g $1557.5
More product size
Request For Quotation

4-(HYDROXYMETHYL)BENZONITRILE Properties

Melting point 39-43 °C(lit.)
Boiling point 203 °C(Press: 53 Torr)
Density 1.16±0.1 g/cm3(Predicted)
Flash point >230 °F
storage temp. Sealed in dry,Room Temperature
pka 13.99±0.10(Predicted)
Appearance White to light yellow Solid
Water Solubility Insoluble in water.
BRN 2206193
InChI 1S/C8H7NO/c9-5-7-1-3-8(6-10)4-2-7/h1-4,10H,6H2
InChIKey XAASLEJRGFPHEV-UHFFFAOYSA-N
SMILES OCc1ccc(cc1)C#N
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  26-36
RIDADR  3439
WGK Germany  3
F  10
HazardClass  6.1
HS Code  29269090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Limited Quantities 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
1
2 0

4-(HYDROXYMETHYL)BENZONITRILE price More Price(69)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 527750 4-(Hydroxymethyl)benzonitrile 95% 874-89-5 10g $452 2026-04-30 Buy
Biosynth FC70532 4-Cyanobenzyl alcohol 874-89-5 25g $329.25 2026-06-04 Buy
Biosynth FC70532 4-Cyanobenzyl alcohol 874-89-5 50g $595 2026-06-04 Buy
Biosynth FC70532 4-Cyanobenzyl alcohol 874-89-5 100g $1006 2026-06-04 Buy
Biosynth FC70532 4-Cyanobenzyl alcohol 874-89-5 250g $1557.5 2026-06-04 Buy
Product number Packaging Price Buy
527750 10g $452 Buy
FC70532 25g $329.25 Buy
FC70532 50g $595 Buy
FC70532 100g $1006 Buy
FC70532 250g $1557.5 Buy

4-(HYDROXYMETHYL)BENZONITRILE Chemical Properties,Uses,Production

Uses

4-(Hydroxymethyl)benzonitrile [p-(hydroxymethyl)benzonitrile] may be used to synthesize p-((vinyloxy)methyl)benzonitrile (VOMBN).

Definition

ChEBI: 4-cyanobenzyl alcohol is an aromatic primary alcohol. It is functionally related to a benzyl alcohol.

General Description

4-(Hydroxymethyl)benzonitrile can be synthesized via hydrosilylation reaction in the presence of Fe complex Bu4N[Fe(CO)3(NO)] [catalyst]. It can also be prepared from 4-(aminomethyl) benzyl alcohol.

Synthesis

4-Cyanobenzoic acid

619-65-8

4-(HYDROXYMETHYL)BENZONITRILE

874-89-5

8A. Synthesis of 4-hydroxymethylbenzonitrile: Boron trifluoride diethyl ether compound (0.85 mL, 6.8 mmol) was slowly added to a solution containing 4-cyanobenzoic acid (1.0 g, 6.8 mmol) and tetrahydrofuran (10 mL). Borane-tetrahydrofuran complex (1.0 M, 13.6 mL) was added dropwise to the reaction mixture at room temperature, during which no significant exothermic phenomenon was observed. The reaction mixture was stirred continuously for 2 h at room temperature and then concentrated under vacuum. The obtained residue was dissolved in ethyl acetate (50 mL), washed sequentially with saturated sodium bicarbonate solution and brine, dried over anhydrous sodium sulfate and filtered, and the filtrate was concentrated in vacuum to afford the target product 4-hydroxymethylbenzonitrile (0.900 g, 95% yield) as a white solid.1H NMR (400 MHz, CDCl3) δ 4.65 (s, 2H), 7.38 (d 2H), 7.53 (d, 2H).

References

[1] Patent: US2007/270438, 2007, A1. Location in patent: Page/Page column 39
[2] Tetrahedron Letters, 2003, vol. 44, # 16, p. 3427 - 3428
[3] Advanced Synthesis and Catalysis, 2014, vol. 356, # 2-3, p. 308 - 312
[4] Dalton Transactions, 2016, vol. 45, # 19, p. 8265 - 8271

4-(HYDROXYMETHYL)BENZONITRILE Preparation Products And Raw materials

Raw materials

4-Cyanobenzylamine 4-Cyanobenzaldehyde 4-Cyanobenzoic acid 4-(Chloromethyl)tolunitrile Ethyl 4-cyanobenzoate
4-Iodobenzyl alcohol BORANE THF Sodium bicarbonate Boron trifluoride diethyl etherate Water

1of2

Preparation Products

(4-CYANOBENZYL)PHOSPHONIC ACID DIETHYL ESTER TERT-BUTYL 4-(BROMOMETHYL)BENZYLCARBAMATE (4-AMINOMETHYL-PHENYL)-METHANOL (4-Methylaminomethyl-phenyl)-methanol (4-Aminophenyl)-methanol hydrochloride

4-(HYDROXYMETHYL)BENZONITRILE Suppliers

Global( 185)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29812 58
Changzhou Ansciep Chemical Co., Ltd. 		+86 519 86305871 sales@ansciepchem.com CHINA 4241 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
Fuxin Pharmaceutical 		+86-021-021-50872116 +8613122107989 contact@fuxinpharm.com China 10000 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Shanghai Rlavie Technology Co ltd 		+86-021-67759270 +8617717059219 sales@rlavie.com China 1030 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Changzhou Ansciep Chemical Co., Ltd. 		58
Accela ChemBio Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Fuxin Pharmaceutical 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Shanghai Rlavie Technology Co ltd 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58

View Lastest Price from 4-(HYDROXYMETHYL)BENZONITRILE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Cyanobenzyl alcohol pictures 2022-04-22 4-Cyanobenzyl alcohol
874-89-5
 98%min 100kgs/month Shanghai Rlavie Technology Co ltd
4-(HYDROXYMETHYL)BENZONITRILE pictures 2019-07-10 4-(HYDROXYMETHYL)BENZONITRILE
874-89-5
 $1.00 1KG 98% 150KG Career Henan Chemical Co

4-(HYDROXYMETHYL)BENZONITRILE Spectrum

4-(HYDROXYMETHYL)BENZONITRILE(874-89-5)1HNMR4-(HYDROXYMETHYL)BENZONITRILE(874-89-5)IR

874-89-5(4-(HYDROXYMETHYL)BENZONITRILE)Related Search:

4-(HYDROXYMETHYL)BENZONITRILE Methyl 4-cyanobenzoate Citalopram 5-Cyanophthalide TRANS-4-(5-PENTYL-1,3-DIOXAN-2-YL)BENZONITRILE
2-(4-CYANOPHENYL)-5-N-PROPYL-1,3-DIOXANE 4-Cyanobenzoic acid Ethyl 4-cyanobenzoate 4-[4-(DIMETHYLAMINO)-1-(4-FLUOROPHENYL)-1-HYDROXYBUTYL]-3-(HYDROXYMETHYL)-BENZONITRILE, MONOHYDROBROMIDE (-)-4-(4-Dimethylamino)-1-(4-fluorophenyl)-1-(hydroxybuty)-3-hydroxymethyl)-benzonitrile hemi D-(+)-di-p-toloyltartaric acid salt
4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile hydrochloride 3-Fluoro-4-(hydroxymethyl)benzonitrile 4-[(1S)-(4-dimethylamino)-1-(4-fluotophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile 1/2(+)-Di-1,4-toluoyl-D-tartaric acid 4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile Bis(4-cyanophenyl)methanol
4-(1H-1,2,4-Triazol-1-ylmethyl)benzonitrile 3-CYANOBENZYL ALCOHOL 4-oxiran-2-ylbenzonitrile

1of4

4-(HYDROXYMETHYL)BENZONITRILE 4-Cyanobenzenemethanol Tranexamic Acid Impurity 13 4-(hydroxymethyl)benzenecarbonitrile 4-methylolbenzonitrile 4-(Hydroxymethyl)benzonitrile 95% Benzonitrile,4-(hydroxyMethyl)- 4-(HydroxyMethyl)benzonitrile, puruM, >=97.0% (GC) 4-((N-nitrosoacetamido)methyl)benzoic acid 4-CYANOBENZYL ALCOHOL 4-cyanobeznyl alcohol 874-89-5 HOCH2C6H4CN Organic Building Blocks Nitrogen Compounds Cyanides/Nitriles Building Blocks C8 to C9 Building Blocks C8 to C9 Chemical Synthesis Cyanides/Nitriles Nitrogen Compounds Organic Building Blocks Benzhydrols, Benzyl & Special Alcohols