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ChemicalBook >> CAS DataBase List >>(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Structure
(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine structure
CAS No.
132335-44-5
Chemical Name:
(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine
Synonyms
(s)-3-(dimethylamino)-1-(2-thienyl)-1-propanol;(S)-3-(dimethylamino)-1-(thiophen-2-yl)propan-1-ol;(S)-3-(Dimethylamino)-1-(2-thienyl)propan-1-ol;Duloxetine-18;Duloxetine Impurity49;Duloxetine intermediate AA;InterMediate of Duloxetine;Duloxetine Hydroxy IMpurity;Duloxetine S-Hydroxy Impurity;S-(-)-N,N-Dimethyl-3-hydroxy-3
CBNumber:
CB9204180
Molecular Formula:
C9H15NOS
Molecular Weight:
185.29
MDL Number:
MFCD07782107
MOL File:
132335-44-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-04 14:10:54
Product description Number Pack Size Price
(S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol >98.0%(GC)(T) D4010 1g $18
(S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol >98.0%(GC)(T) D4010 5g $50
(S)-3-(Dimethylamino)-1-(2-thienyl)propan-1-ol ID58105 5g $250
(S)-3-(Dimethylamino)-1-(2-thienyl)propan-1-ol ID58105 2g $250
(S)-3-(Dimethylamino)-1-(2-thienyl)propan-1-ol ID58105 1g $250
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(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Properties

Melting point 78-80°C
Boiling point 290°C
Density 1.111
Flash point 129°C
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
pka 13.74±0.20(Predicted)
form Solid
color White
InChI InChI=1/C9H15NOS/c1-10(2)6-5-8(11)9-4-3-7-12-9/h3-4,7-8,11H,5-6H2,1-2H3/t8-/s3
InChIKey XWCNSHMHUZCRLN-SBYBRXNCNA-N
SMILES C(N(C)C)C[C@H](O)C1SC=CC=1 |&1:5,r|
CAS DataBase Reference 132335-44-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Risk Statements  36/37/38
Safety Statements  26-36/37/39
HS Code  29349990
REACH Registrations Active
NFPA 704
0
2 0

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical D4010 (S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol >98.0%(GC)(T) 132335-44-5 1g $18 2026-04-30 Buy
TCI Chemical D4010 (S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol >98.0%(GC)(T) 132335-44-5 5g $50 2026-04-30 Buy
Biosynth ID58105 (S)-3-(Dimethylamino)-1-(2-thienyl)propan-1-ol 132335-44-5 5g $250 2026-06-04 Buy
Biosynth ID58105 (S)-3-(Dimethylamino)-1-(2-thienyl)propan-1-ol 132335-44-5 2g $250 2026-06-04 Buy
Biosynth ID58105 (S)-3-(Dimethylamino)-1-(2-thienyl)propan-1-ol 132335-44-5 1g $250 2026-06-04 Buy
Product number Packaging Price Buy
D4010 1g $18 Buy
D4010 5g $50 Buy
ID58105 5g $250 Buy
ID58105 2g $250 Buy
ID58105 1g $250 Buy

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

A Duloxetine intermediate.

Synthesis

3-(DIMETHYLAMINO)-1-(2-THIENYL)-1-PROPANONE

13196-35-5

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine

132335-44-5

General procedure for the synthesis of (S)-N,N-dimethyl-3-hydroxy-3-(2-thienyl)propylamine from N/A (Example 23): under argon protection, (R,R)-Cl2((R)-hexylBINAP)((R)-DAIPEN) (30.5 mg, 0.025 mmol), 2-propanol (100 ml), 1.0 M tert-butyl potassium oxychloride solution of 2-propanol (7.5 ml, 7.5 mmol) and 3-(N,N-dimethylamino)-1-(2-thienyl)-1-propanone (22.9 g, 0.125 mol) were added sequentially to a glass autoclave. After the reaction system was degassed several times and replaced with argon, hydrogen was introduced to a predetermined pressure to start the reaction. After stirring the reaction at 28°C for 6 hours, the reaction system was returned to normal temperature and pressure. The reaction solution was concentrated, heptane was added and the precipitated solid was filtered. The resulting solid was dried under reduced pressure to afford (S)-N,N-dimethyl-3-hydroxy-3-(2-thienyl)propylamine 18.5 g in 80.0% yield. The optical purity of the product was determined by chiral column HPLC, and the result showed that the optical purity was 99% ee. Note: (R)-DAIPEN is (R)-1-isopropyl-2,2-bis(p-methoxyphenyl)ethylenediamine, and xylBINAP is 2,2'-bis(bis-3,5-dimethylphosphinodiphenyl)-1,1'-binaphthyl.

References

[1] Patent: EP1506965, 2005, A1. Location in patent: Page/Page column 35
[2] Angewandte Chemie (International ed. in English), 2004, vol. 43, # 21, p. 2816 - 2819
[3] Chemistry - A European Journal, 2011, vol. 17, # 28, p. 7760 - 7763
[4] Patent: US8426178, 2013, B2. Location in patent: Page/Page column
[5] Chemical Communications, 2015, vol. 51, # 61, p. 12328 - 12331

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine synthesis

5424-47-5
132335-44-5
Synthesis of (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine from 2-THIENYL-2-DIMETHYLAMINOETHYL KETONE HCL

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Preparation Products And Raw materials

Raw materials

3-(Dimethylamino)-1-(2-thienyl)-1-propanol Dimethylamine 3-(DIMETHYLAMINO)-1-(2-THIENYL)-1-PROPANONE (2S)-HYDROXY(PHENYL)ACETIC ACID (1S)-3-(DIMETHYLAMINO)-1-(2-THIENYL)PROPAN-1-OL (1:1) (SALT) 2-THIENYL-2-DIMETHYLAMINOETHYL KETONE HCL
3-CHLORO-1-(2-THIENYL)-1-PROPANOL Hydrogen Potassium Recombinant Human Telomerase Isopropyl alcohol

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Preparation Products

(R)-N,N-dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine (S)-(+)-N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine (S)-N,N-DIMETHYL-[3-(2-THIENYL)-3-(1-NAPHTHYLOXY)PROPYL]AMINE--PHOSPHORIC ACID (1:1)

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Suppliers

Global( 378)Suppliers
Supplier Tel Email Country ProdList Advantage
changzhou huayang technology co., ltd
+8615250961469 2571773637@qq.com China 9628 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21533 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10399 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 sales@amoychem.com China 6339 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19935 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 contact@trustwe.com China 5742 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17339 58
Supplier Advantage
changzhou huayang technology co., ltd
58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Xiamen AmoyChem Co., Ltd 		58
BOC Sciences 		58
CONIER CHEM AND PHARMA LIMITED 		58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		58
SIMAGCHEM CORP 		58

View Lastest Price from (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine pictures 2026-08-04 (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine
132335-44-5
 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
132335-44-5 pictures 2026-07-01 132335-44-5
132335-44-5
 $50.00-55.00 10kg 99.99% 100Tons Hebei Dangtong Import and export Co LTD
(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine pictures 2026-03-20 (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine
132335-44-5
 $1.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
  • 132335-44-5 pictures
  • 132335-44-5
    132335-44-5
  • $50.00-55.00
  • 99.99%
  • Hebei Dangtong Import and export Co LTD

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Spectrum

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine(132335-44-5)1HNMR

132335-44-5((S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine)Related Search:

Dimethyl disulfide ETHANE 3-Dimethylaminopropylamine Diisopropylamine Dimethyl sulfate
Dimethyl ether Dimethyl carbonate Isopropylamine Tetrahydrothiophene Dimethyl fumarate
1-Propanol Cephalothin sodium Dacthal Dimethyl sulfoxide N,N-Dimethylformamide
3-(Dimethylamino)-1-(2-thienyl)-1-propanol D/L-AMPHETAMINE HYDROCHLORIDE (-)-2-[METHYLAMINO]-1-PHENYLPROPANE

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(S)-1-HYDROXY-1-(2-THIENYL)-3-DIMETHYLAMINOPROPANE (S)-1-BETA-HYDROXY-1-(2-THIENYL)-3-DIMETHYLAMINOPROPANE (S)-(-)-N-DIMETHYL-3-HYDROXY-3-(2-THIENYL)-PROPANAMINE S-(-)-N,N-DIMETHYL-3-HYDROXY-3-(2-THIENYL)PROPANAMINE (S)-N,N-dimethyl-3-hydroxy-3-(2-thienyl)-2-propanamine Duloxetine intermediate AA (S)-(-)-N,N-dimethyl-3-hydroxy-3-(2-thienyl)propylamine (S)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)-1-propylamine S-(-)-N,N-Dimethyl-3-hydroxy-3 S-(-)-N,N-DIME-3-HY-3-(2-THIENYL)1PROPAMINE S-(-)-N,N-Dime-3-Hy-3-(2-Thienyl)propamine (1S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol S-(-)-N,N-Dimethyl-3-hydroxy-(2-thienol)propanamine (S)-(-)-N,N-DiMethyl-3-hydroxy-3-(2-thienyl)propan (S)-N,N-DiMethyl-3-(2-thienyl)-3-hydroxypropanaMine (S)-2-[3-(Dimethylamino)-1-hydroxypropyl]thiophene InterMediate of Duloxetine (S)-(-)-N,N-diMethyl-3-hydroxy-3-(2-thienyl) Duloxetine Hydroxy IMpurity (S)-(-)-alpha-methyl-1-naphthalenemethhanol (S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol 2-Thiophenemethanol, a-[2-(dimethylamino)ethyl]-, (aS)- (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propamine (S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol,99%e.e. Duloxetine S-Hydroxy Impurity S-(-)-N, N-dimethyl-3-hydroxy-3- (2-thiophene) propylamine (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine in stock Factory DUG-4 (S)-(-)-N,N-Dimethyl-3-Hydroxy-3-(2-Thienyl) Propanamine Duloxetine-18 (1S)-3-(dimethylamino)-1-(thiophen-2-yl)propan-1-ol (S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol> (S)-3-dimethylamino-1-(2-thiophene)-1-propanol Duloxetine Dimethylaminopropanol Impurity 2-Thiophenemethanol, α-[2-(dimethylamino)ethyl]-, (αS)- (S)-(-)N, N-dimethyl-3-hydroxy 3-(2-thieyl)propanamine (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine(For export only) (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine ISO 9001：2015 REACH (S)-1-β-Hydroxy-1-(2-thienyl)-3-dimethylaminopropane S-(-)-N,N-dimethtl-3-hydroxy-3-(2-thienyl)propanamine Duloxetine Dimethylaminopropanol Impurity/ Duloxetine Hydroxy Impurity Duloxetine Impurity49 (S)-N,N-Dimethyl-3-(thiophen-2-yl)-3-hydroxy-propanamine (s)-3-(dimethylamino)-1-(thiophen-2-yl)propan-1-Ol /mandelate salt (S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol(DMTP) (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propana (S)-(-)-3-(dimethylamino)-1-(2-thienyl)-1-propanol mandalate salt (1S)-3-(dimethylamino)-1-(2-thienyl)propan-1-ol N,N diethyl-3- hydroxy-3-(2- thienyl)- propanamine,Duloxetine Hydrochloride (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(thiophen-2-yl)-propanamine (S)-3-(Dimethylamino)-1-(2-thienyl)propan-1-ol (s)-3-(dimethylamino)-1-(2-thienyl)-1-propanol (S)-3-(dimethylamino)-1-(thiophen-2-yl)propan-1-ol 132335-44-5 1323235-44-5 C9H15NOS2 C9H15NOS Heterocycles Intermediates & Fine Chemicals