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ChemicalBook >> CAS DataBase List >>(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Structure
(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine structure
CAS No.
132335-44-5
Chemical Name:
(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine
Synonyms
(s)-3-(dimethylamino)-1-(2-thienyl)-1-propanol;(S)-3-(Dimethylamino)-1-(2-thienyl)propan-1-ol;(S)-3-(dimethylamino)-1-(thiophen-2-yl)propan-1-ol;Duloxetine-18;Duloxetine Impurity49;Duloxetine intermediate AA;InterMediate of Duloxetine;Duloxetine Hydroxy IMpurity;Duloxetine S-Hydroxy Impurity;S-(-)-N,N-Dimethyl-3-hydroxy-3
CBNumber:
CB9204180
Molecular Formula:
C9H15NOS
Molecular Weight:
185.29
MDL Number:
MFCD07782107
MOL File:
132335-44-5.mol
MSDS File:
SDS
Last updated:2025-08-08 17:45:00
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(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Properties

Melting point 78-80°C
Boiling point 290°C
Density 1.111
Flash point 129°C
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
pka 13.74±0.20(Predicted)
form Solid
color White
InChI InChI=1/C9H15NOS/c1-10(2)6-5-8(11)9-4-3-7-12-9/h3-4,7-8,11H,5-6H2,1-2H3/t8-/s3
InChIKey XWCNSHMHUZCRLN-SBYBRXNCNA-N
SMILES C(N(C)C)C[C@H](O)C1SC=CC=1 |&1:5,r|
CAS DataBase Reference 132335-44-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Risk Statements  36/37/38
Safety Statements  26-36/37/39
HS Code  29349990
NFPA 704
0
2 0

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical D4010 (S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol >98.0%(GC)(T) 132335-44-5 1g $22 2025-07-31 Buy
TCI Chemical D4010 (S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol >98.0%(GC)(T) 132335-44-5 5g $62 2025-07-31 Buy
TRC H961825 (S)-1-β-Hydroxy-1-(2-thienyl)-3-dimethylaminopropane 132335-44-5 1g $50 2021-12-16 Buy
AK Scientific I572 S-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine 132335-44-5 100g $931 2021-12-16 Buy
American Custom Chemicals Corporation CCH0012832 (S)-(-)-N-DIMETHYL-3-HYDROXY-3-(2-THIENYL)PROPANAMINE 98.00% 132335-44-5 1G $1746.36 2021-12-16 Buy
Product number Packaging Price Buy
D4010 1g $22 Buy
D4010 5g $62 Buy
H961825 1g $50 Buy
I572 100g $931 Buy
CCH0012832 1G $1746.36 Buy

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

A Duloxetine intermediate.

Synthesis

3-(DIMETHYLAMINO)-1-(2-THIENYL)-1-PROPANONE

13196-35-5

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine

132335-44-5

General procedure for the synthesis of (S)-N,N-dimethyl-3-hydroxy-3-(2-thienyl)propylamine from N/A (Example 23): under argon protection, (R,R)-Cl2((R)-hexylBINAP)((R)-DAIPEN) (30.5 mg, 0.025 mmol), 2-propanol (100 ml), 1.0 M tert-butyl potassium oxychloride solution of 2-propanol (7.5 ml, 7.5 mmol) and 3-(N,N-dimethylamino)-1-(2-thienyl)-1-propanone (22.9 g, 0.125 mol) were added sequentially to a glass autoclave. After the reaction system was degassed several times and replaced with argon, hydrogen was introduced to a predetermined pressure to start the reaction. After stirring the reaction at 28°C for 6 hours, the reaction system was returned to normal temperature and pressure. The reaction solution was concentrated, heptane was added and the precipitated solid was filtered. The resulting solid was dried under reduced pressure to afford (S)-N,N-dimethyl-3-hydroxy-3-(2-thienyl)propylamine 18.5 g in 80.0% yield. The optical purity of the product was determined by chiral column HPLC, and the result showed that the optical purity was 99% ee. Note: (R)-DAIPEN is (R)-1-isopropyl-2,2-bis(p-methoxyphenyl)ethylenediamine, and xylBINAP is 2,2'-bis(bis-3,5-dimethylphosphinodiphenyl)-1,1'-binaphthyl.

References

[1] Patent: EP1506965, 2005, A1. Location in patent: Page/Page column 35
[2] Angewandte Chemie (International ed. in English), 2004, vol. 43, # 21, p. 2816 - 2819
[3] Chemistry - A European Journal, 2011, vol. 17, # 28, p. 7760 - 7763
[4] Patent: US8426178, 2013, B2. Location in patent: Page/Page column
[5] Chemical Communications, 2015, vol. 51, # 61, p. 12328 - 12331

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine synthesis

5424-47-5
132335-44-5
Synthesis of (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine from 2-THIENYL-2-DIMETHYLAMINOETHYL KETONE HCL

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Preparation Products And Raw materials

Raw materials

3-(Dimethylamino)-1-(2-thienyl)-1-propanol Dimethylamine 3-(DIMETHYLAMINO)-1-(2-THIENYL)-1-PROPANONE (2S)-HYDROXY(PHENYL)ACETIC ACID (1S)-3-(DIMETHYLAMINO)-1-(2-THIENYL)PROPAN-1-OL (1:1) (SALT) 2-THIENYL-2-DIMETHYLAMINOETHYL KETONE HCL
3-CHLORO-1-(2-THIENYL)-1-PROPANOL Hydrogen Potassium Recombinant Human Telomerase Isopropyl alcohol

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Preparation Products

(R)-N,N-dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine (S)-(+)-N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine (S)-N,N-DIMETHYL-[3-(2-THIENYL)-3-(1-NAPHTHYLOXY)PROPYL]AMINE--PHOSPHORIC ACID (1:1)

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Suppliers

Global( 382)Suppliers
Supplier Tel Email Country ProdList Advantage
changzhou huayang technology co., ltd
+8615250961469 2571773637@qq.com China 9647 58
Beijing Toachem Chemical Co.,Ltd
+8618311365218 sales@toachem.com China 216 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8617732866630 abby@chuanghaibio.com China 8773 58
Hebei Mujin Biotechnology Co.,Ltd 		+8613288715578 sales@hbmojin.com China 12371 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 deasea125996@gmail.com China 2472 58
Capot Chemical Co.,Ltd. 		+8613336195806 sales@capot.com China 29734 60
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21622 55
AB PharmaTech,LLC 		323-480-4688 sales@acrospharmatech.com United States 989 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29855 58
Supplier Advantage
changzhou huayang technology co., ltd
58
Beijing Toachem Chemical Co.,Ltd
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Mujin Biotechnology Co.,Ltd 		58
Henan Bao Enluo International TradeCo.，LTD 		58
Capot Chemical Co.,Ltd. 		60
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
AB PharmaTech,LLC 		55
career henan chemical co 		58

View Lastest Price from (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
132335-44-5 pictures 2025-08-20 132335-44-5
132335-44-5
 US $55.00-50.00 / kg 10kg 99.99% 100Tons Hebei Dangtong Import and export Co LTD
(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine pictures 2025-08-08 (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine
132335-44-5
 US $0.00 / KG 1KG 99% 50000KG/month Hebei Mujin Biotechnology Co.,Ltd
(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine pictures 2025-06-24 (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine
132335-44-5
 US $1.00 / KG 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
  • 132335-44-5 pictures
  • 132335-44-5
    132335-44-5
  • US $55.00-50.00 / kg
  • 99.99%
  • Hebei Dangtong Import and export Co LTD

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Spectrum

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine(132335-44-5)1HNMR

132335-44-5((S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine)Related Search:

Dimethyl disulfide ETHANE Dimethyl sulfoxide 3-Dimethylaminopropylamine Diisopropylamine
Dimethyl sulfate Dimethyl ether Dimethyl carbonate Isopropylamine Tetrahydrothiophene
Dimethyl fumarate 1-Propanol Cephalothin sodium Dacthal N,N-Dimethylformamide
D/L-AMPHETAMINE HYDROCHLORIDE 3-(Dimethylamino)-1-(2-thienyl)-1-propanol (-)-2-[METHYLAMINO]-1-PHENYLPROPANE

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(S)-1-HYDROXY-1-(2-THIENYL)-3-DIMETHYLAMINOPROPANE (S)-1-BETA-HYDROXY-1-(2-THIENYL)-3-DIMETHYLAMINOPROPANE (s)-3-(dimethylamino)-1-(2-thienyl)-1-propanol (S)-(-)-N-DIMETHYL-3-HYDROXY-3-(2-THIENYL)-PROPANAMINE S-(-)-N,N-DIMETHYL-3-HYDROXY-3-(2-THIENYL)PROPANAMINE (S)-N,N-dimethyl-3-hydroxy-3-(2-thienyl)-2-propanamine Duloxetine intermediate AA (S)-(-)-N,N-dimethyl-3-hydroxy-3-(2-thienyl)propylamine (S)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)-1-propylamine S-(-)-N,N-Dimethyl-3-hydroxy-3 S-(-)-N,N-DIME-3-HY-3-(2-THIENYL)1PROPAMINE (S)-3-(dimethylamino)-1-(thiophen-2-yl)propan-1-ol S-(-)-N,N-Dime-3-Hy-3-(2-Thienyl)propamine (1S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol S-(-)-N,N-Dimethyl-3-hydroxy-(2-thienol)propanamine (S)-(-)-N,N-DiMethyl-3-hydroxy-3-(2-thienyl)propan (S)-N,N-DiMethyl-3-(2-thienyl)-3-hydroxypropanaMine (S)-2-[3-(Dimethylamino)-1-hydroxypropyl]thiophene InterMediate of Duloxetine (S)-(-)-N,N-diMethyl-3-hydroxy-3-(2-thienyl) Duloxetine Hydroxy IMpurity (S)-(-)-alpha-methyl-1-naphthalenemethhanol (S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol 2-Thiophenemethanol, a-[2-(dimethylamino)ethyl]-, (aS)- (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propamine (S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol,99%e.e. Duloxetine S-Hydroxy Impurity S-(-)-N, N-dimethyl-3-hydroxy-3- (2-thiophene) propylamine (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine in stock Factory DUG-4 (S)-(-)-N,N-Dimethyl-3-Hydroxy-3-(2-Thienyl) Propanamine Duloxetine-18 (1S)-3-(dimethylamino)-1-(thiophen-2-yl)propan-1-ol (S)-3-(Dimethylamino)-1-(2-thienyl)propan-1-ol (S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol> (S)-3-dimethylamino-1-(2-thiophene)-1-propanol Duloxetine Dimethylaminopropanol Impurity 2-Thiophenemethanol, α-[2-(dimethylamino)ethyl]-, (αS)- (S)-(-)N, N-dimethyl-3-hydroxy 3-(2-thieyl)propanamine (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine(For export only) (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine ISO 9001：2015 REACH (S)-1-β-Hydroxy-1-(2-thienyl)-3-dimethylaminopropane S-(-)-N,N-dimethtl-3-hydroxy-3-(2-thienyl)propanamine Duloxetine Dimethylaminopropanol Impurity/ Duloxetine Hydroxy Impurity Duloxetine Impurity49 (S)-N,N-Dimethyl-3-(thiophen-2-yl)-3-hydroxy-propanamine (s)-3-(dimethylamino)-1-(thiophen-2-yl)propan-1-Ol /mandelate salt (S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol(DMTP) (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propana (S)-(-)-3-(dimethylamino)-1-(2-thienyl)-1-propanol mandalate salt (1S)-3-(dimethylamino)-1-(2-thienyl)propan-1-ol N,N diethyl-3- hydroxy-3-(2- thienyl)- propanamine,Duloxetine Hydrochloride 132335-44-5 1323235-44-5 C9H15NOS2 C9H15NOS Heterocycles Intermediates & Fine Chemicals Pharmaceuticals