Nilvadipine | 75530-68-6

Nilvadipine Properties

Melting point	148-150°C
Boiling point	511.83°C (rough estimate)
Density	1.3937 (rough estimate)
refractive index	1.5900 (estimate)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	DMSO: soluble15mg/mL, clear
form	powder
pka	-0.81±0.70(Predicted)
color	white to beige
Merck	14,6545
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI	1S/C19H19N3O6/c1-10(2)28-19(24)15-11(3)21-14(9-20)17(18(23)27-4)16(15)12-6-5-7-13(8-12)22(25)26/h5-8,10,16,21H,1-4H3
InChIKey	FAIIFDPAEUKBEP-UHFFFAOYSA-N
SMILES	[N+](=O)([O-])c1cc(ccc1)C2C(=C(NC(=C2C(=O)OC)C#N)C)C(=O)OC(C)C
FDA UNII	0214FUT37J
ATC code	C08CA10
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302+H312+H332-H315-H319

Precautionary statements

P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P302+P352+P312-P304+P340+P312

Hazard Codes

Xn

Risk Statements

22

WGK Germany

3

RTECS

US7968300

HS Code

2933.39.9200

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

Toxicity

LD50 oral in rat: 1560mg/kg

NFPA 704

	0
3		0

Nilvadipine price More Price(60)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0945	Nilvadipine ≥98% (HPLC)	75530-68-6	10mg	$54.4	2026-04-30	Buy
Sigma-Aldrich	SML0945	Nilvadipine ≥98% (HPLC)	75530-68-6	50mg	$153	2026-04-30	Buy
TCI Chemical	N0899	Nilvadipine >95.0%(N)	75530-68-6	1g	$108	2026-04-30	Buy
TCI Chemical	N0899	Nilvadipine >95.0%(N)	75530-68-6	5g	$322	2026-04-30	Buy
Cayman Chemical	21243	Nilvadipine ≥98%	75530-68-6	5mg	$36	2026-04-30	Buy

Product number	Packaging	Price	Buy
SML0945	10mg	$54.4	Buy
SML0945	50mg	$153	Buy
N0899	1g	$108	Buy
N0899	5g	$322	Buy
21243	5mg	$36	Buy

Nilvadipine Chemical Properties, Uses, Production

Description

Nilvadipine is a new, second-generation calcium channel blocker effective in the treatment of hypertension and angina pectoris. Its potent inhibitory effect on the stimulated chemotaxis of smooth muscle cells and protective action against calcium deposition suggest that nilvadipine may be useful for preventing and treating atherosclerosis.

Chemical Properties

Yellow Prisms

Originator

Fujisawa (Japan)

Uses

Used as an antihypertensive and antianginal.

Uses

antihypertensive;calcium channel blocker

Definition

ChEBI: Nilvadipine is an isopropyl ester, a methyl ester, a nitrile and a dihydropyridine.

Manufacturing Process

To a solution of isopropyl ester of 6-formyl-5-methoxycarbonyl-2-methyl-4-(3- nitrophenyl)-1,4-dihydropyridine- 3-carboxylic acid (4.5 g) in acetic acid (35 ml) were added hydroxylamine hydrochloride (0.97 g) and sodium acetate (1.43 g), and the mixture was stirred at ambient temperature for 2.5 hours. After acetic anhydride (4.14 g) was added to this reaction mixture, the mixture was stirred at ambient temperature for 1.5 hours and at 95-100°C for additional 4 hours. The acetic acid and the excess of acetic anhydride were removed in vacuum, followed by adding water to the residue and it was neutralized with a saturated aqueous solution of sodium bicarbonate. This aqueous suspension was extracted twice with ethyl acetate, and the combined extract was washed with water, dried over anhydrous magnesium sulfate and evaporated to dryness under reduced pressure to give a reddish-brown oil (4.88 g), which was chromatographed over silica gel (150 g) with a mixture of benzene and ethyl acetate (10:1 by volume) as an eluent to give a crude crystals (2.99 g). These were recrystallized from ethanol to give yellow prisms (1.89 g) of isopropyl ester of 6-cyano-5-methoxycarbonyl-2-methyl-4-(3- nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid melting point 148-150°C (yellow prisms from ethanol); [α]D20 = 222.4° (c = 1 in methanol).

brand name

Nivadil

Therapeutic Function

Calcium entry blocker, Antihypertensive

References

[1] DANIEL PARIS. The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and Tau hyperphosphorylation.[J]. The Journal of Biological Chemistry, 2014, 289 49: 33927-33944. DOI:10.1074/jbc.m114.608091
[2] ROSENTHAL J. Nilvadipine: profile of a new calcium antagonist. An overview.[J]. Journal of Cardiovascular Pharmacology, 1994, 24 Suppl 2: S92-107.
[3] V NIMMRICH A E. Calcium channel blockers and dementia[J]. British Journal of Pharmacology, 2013, 169 6: 1203-1210. DOI:10.1111/bph.12240
[4] YASUMASA OTORI. Protective effect of nilvadipine against glutamate neurotoxicity in purified retinal ganglion cells[J]. Brain Research, 2003, 961 2: Pages 213-219. DOI:10.1016/s0006-8993(02)03951-3

Nilvadipine Preparation Products And Raw materials

Raw materials

Erythromycin Estolate Methyl 4,4-dimethoxyacetylacetate (2-Methyl-1H-indol-3-yl)-oxo-acetic acid ethyl ester Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Hydroxylamine hydrochloride

Crotonic acid Hydroxylamine Acetic anhydride Topotecan Sodium acetate

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Preparation Products

Nilvadipine Suppliers

Global Suppliers ( 194)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2110	70
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
China Langchem Inc.	0086-21-58956006		China	7798	57
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
INTATRADE GmbH	66
3B Pharmachem (Wuhan) International Co.,Ltd.	69
TCI (Shanghai) Development Co., Ltd.	81
Pure Chemistry Scientific Inc.	62
LGM Pharma	70
Chemsky（shanghai）International Co.,Ltd.	50
China Langchem Inc.	57
BOC Sciences	65

View Latest Price from Nilvadipine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-10	Nilvadipine 75530-68-6	$30.00-37.00		99.93%	10g	TargetMol Chemicals Inc.
2026-07-14	Nilvadipine 75530-68-6	$30.00-37.00		99.93%	10g	TargetMol Chemicals Inc.
2020-05-12	Nilvadipine 75530-68-6		1KG	99.0%	500 MT	Shaanxi Dideu Medichem Co. Ltd

Nilvadipine
75530-68-6
$30.00-37.00
99.93%
TargetMol Chemicals Inc.

Nilvadipine
75530-68-6
$30.00-37.00
99.93%
TargetMol Chemicals Inc.

Nilvadipine
75530-68-6
99.0%
Shaanxi Dideu Medichem Co. Ltd

Nilvadipine Spectrum

Nilvadipine(75530-68-6)MS Nilvadipine(75530-68-6)¹HNMR Nilvadipine(75530-68-6)¹³CNMR Nilvadipine(75530-68-6)IR1 Nilvadipine(75530-68-6)IR2

75530-68-6 (Nilvadipine) Related Search:

Propyl gallate Nisoldipine Nitrendipine Dihydromyrcenol Propyl acetate

Methanol Isopropyl laurate Isopropyl alcohol Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Methylparaben

Tribenuron methyl Isopropyl acetate Methyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Methyl Ester M-NIFEDIPINE

Nilvadipine (R)-(+)-Nilvadipine,(R)-Nilvadipine (S)-(-)-Nilvadipine,(S)-Nilvadipine

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2-cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-5-pyridinedicarboxylicacid 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-isopropyl 5-methyl ester BAY-e-6927 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-isopropyl ester 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O5-isopropyl ester O3-methyl ester 3-O-methyl 5-O-propan-2-yl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate O3-methyl O5-propan-2-yl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 5-Isopropyl 3-Methyl Ester 5-Isopropyl 3-Methyl 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate Nilvadipine (ARC029) Nivadip 3,5-Pyridinedicarboxylicacid, 2-cyano-1,4-dihydro-6-Methyl-4-(3-nitrophenyl)-, 3-Methyl5-(1-Methylethyl) ester 5-isopropyl 3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate ARC029 5-Isopropyl-3-methyl-2-cyano-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate Isopropyl 6-cyano-5-methoxycarbonyl-2-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate SKF- Nilvadipine-d4 Nilvadipine, >=99% 3-methyl-5-(1-methylethyl)ester fk235 SKF-102362 NILVADIPINE 2-CYANO-1,4-DIHYDRO-6-METHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID 3-METHYL 5-(1-METHYLETHYL) ESTER 5-isopropyl-3-methyl 2-cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate Isopropyl-6-formyl-5-methoxycarbonyl-2-methyl-4-(3-nitrophenyl)-1,4- dihydropyridine-3-carboxylate FR-34235 ESCOR Nilvaldipine 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Methyl 5-(1-Methylethyl) Ester, FR-34235, SKF-102362, Escor, 3,5-Pyridinedicarboxylic acid, 2-cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-methyl 5-(1-methylethyl) ester (9CI) CL 287389 dl-Nilvadipine Nivadil Escor：Nivadil Nivadipine Nivaldipine Nilvadipine Impurity FK235;ESCOR;FR34235;NIVADIL;NIVADIP 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-propan-2-yl ester Nilvadipine> Nilvadipine RS 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 5-Isopropyl 3-Methyl Ester Nilvadipine USP/EP/BP Nilvadipine, ≥ 95.0% Nilvadipine, L-type calcium channel blocker Nilvadipine, 10 mM in DMSO 75530-68-6 Inhibitors Intermediates & Fine Chemicals Pharmaceuticals