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5-(Bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole

5-(Bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole structure

CAS No.: 439134-78-8

Chemical Name:: 5-(Bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole

Synonyms: 5-(BroMoMethyl)-4-Methyl-2-(4-(trifluoroMethyl)phenyl)thiazole;Thiazole, 5-(bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-;5-(Bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole

CBNumber:: CB9237478

Molecular Formula:: C12H9BrF3NS

Molecular Weight:: 336.17

MDL Number:: MFCD04115403

MOL File:: 439134-78-8.mol

MSDS File:: SDS

Last updated:2026-09-12 18:56:19

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5-(Bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole Properties

Melting point	64 °C
Boiling point	373.7±52.0 °C(Predicted)
Density	1.551±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	1.58±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
HS Code	2934999090

5-(Bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	PC446072	5-Bromomethyl-4-methyl-2-(4-trifluoromethyl-phenyl)-thiazole 95%	439134-78-8	250mg	$141	2026-06-04	Buy
Apolloscientific	PC446072	5-Bromomethyl-4-methyl-2-(4-trifluoromethyl-phenyl)-thiazole 95%	439134-78-8	1g	$483	2026-06-04	Buy
Matrix Scientific	094932	5-(Bromomethyl)-4-methyl-2-(4-(trifluoromethyl)-phenyl)thiazole	439134-78-8	250.00mg	$44	2026-05-18	Buy
Matrix Scientific	094932	5-(Bromomethyl)-4-methyl-2-(4-(trifluoromethyl)-phenyl)thiazole	439134-78-8	1.00g	$105	2026-05-18	Buy
Matrix Scientific	094932	5-(Bromomethyl)-4-methyl-2-(4-(trifluoromethyl)-phenyl)thiazole	439134-78-8	5.00g	$496	2026-05-18	Buy

Product number	Packaging	Price	Buy
PC446072	250mg	$141	Buy
PC446072	1g	$483	Buy
094932	250.00mg	$44	Buy
094932	1.00g	$105	Buy
094932	5.00g	$496	Buy

5-(Bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole Chemical Properties, Uses, Production

Synthesis

(4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL)METHANOL

317318-96-0

5-(BROMOMETHYL)-4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE

439134-78-8

GENERAL STEPS: (4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methanol (15.0 g, 55.0 mmol) obtained in Example 2 was dissolved in anhydrous dichloromethane (300 mL). Triphenylphosphine (TPP, 5.7 g, 60.0 mmol, 1.1 eq.) and tetrabromomethane (20.0 g, 60.0 mmol, 1.1 eq.) were added sequentially to the mixture at room temperature. After 1 h of reaction, the solvent was removed by evaporation under reduced pressure. The residual triphenylphosphine oxide was precipitated with a mixture of hexane and ethyl acetate (v/v = 5/1), filtered and evaporated under reduced pressure to afford 5-(bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole (17.2 g, yield: 93%).1H-NMR (300 MHz, CDCl3): δ 8.00 (d, 2H, J = 8.1 Hz), 7.67 (d, 2H, J = 8.2 Hz), 4.72 (s, 2H), 2.47 (s, 3H).13C-NMR (78.5 MHz, CDCl3): δ 165.0, 153.8, 136.9, 132.4, 129.7 (q), 127.0, 126.3 (m), 122.5, 23.8. 15.5.

References

[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 4, p. 685 - 695
[2] Patent: WO2003/106442, 2003, A1. Location in patent: Page 13
[3] Patent: WO2006/121223, 2006, A1. Location in patent: Page/Page column 15
[4] Patent: WO2003/106442, 2003, A1. Location in patent: Page 13-14

5-(Bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole synthesis

Synthesis of 5-(Bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole from (4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl)methanol

5-(Bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole Preparation Products And Raw materials

Raw materials

(4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl)methanol 4-(Trifluoromethyl)thiobenzamide Triphenylphosphine Dichloromethane Carbon tetrabromide

Preparation Products

(4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl)methanamine

5-(Bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole Suppliers

Global Suppliers ( 34)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Shanghai Everchem Co., Ltd	86-29-81325371	info@everchem.cn	China	82	62
NovoChemy Ltd.	86-(0)21-31261262 373522135	sales@novochemy.com	China	6491	58
Yancheng Schiemann Biological Technology Co.,Ltd	0515-88280676; 18921872653	sales@ximanbio.com	China	1524	56
Yancheng KangdiSen Pharmaceutical Co., Ltd.	13812573443;18052965989	tongbenwan22@163.com	China	1975	55
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 17705817739	info@dycnchem.com	China	52451	58
Bide Pharmatech Ltd.	400-1647117 13681763483	product02@bidepharm.com	China	59929	58
Bide Pharmatech Ltd.	400-6005915	sales@picasso-e.com	China	39645	58
Henan Weitixi Chemical Technology Co., Ltd	0371-53370800 18037197114	3807961510@qq.com	China	9977	58

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Shanghai Everchem Co., Ltd	62
NovoChemy Ltd.	58
Yancheng Schiemann Biological Technology Co.,Ltd	56
Yancheng KangdiSen Pharmaceutical Co., Ltd.	55
Amadis Chemical Company Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Bide Pharmatech Ltd.	58
Bide Pharmatech Ltd.	58
Henan Weitixi Chemical Technology Co., Ltd	58

439134-78-8 (5-(Bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole) Related Search:

5-(Bromomethyl)-4-methyl-2-phenyl-1,3-thiazole 5-(Bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole

5-(BroMoMethyl)-4-Methyl-2-(4-(trifluoroMethyl)phenyl)thiazole Thiazole, 5-(bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]- 5-(Bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole 439134-78-8 C12H9BrF3NS