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ChemicalBook >> CAS DataBase List >>5-Bromo-2,4-difluorobenzaldehyde

5-Bromo-2,4-difluorobenzaldehyde

5-Bromo-2,4-difluorobenzaldehyde Structure
5-Bromo-2,4-difluorobenzaldehyde structure
CAS No.
473416-91-0
Chemical Name:
5-Bromo-2,4-difluorobenzaldehyde
Synonyms
5-BroMo-2,4-difluorobenzaldehyde;BENZALDEHYDE, 5-BROMO-2,4-DIFLUORO
CBNumber:
CB92451672
Molecular Formula:
C7H3BrF2O
Molecular Weight:
221
MDL Number:
MFCD09842439
MOL File:
473416-91-0.mol
MSDS File:
SDS
Last updated:2026-05-28 04:59:19
Product description Number Pack Size Price
5-Bromo-2,4-difluorobenzaldehyde 98% PC52118 1g $21
5-Bromo-2,4-difluorobenzaldehyde 98% PC52118 1g $21
5-Bromo-2,4-difluorobenzaldehyde 98% AS115624 5g $27
5-Bromo-2,4-difluorobenzaldehyde 98% AS115624 25g $90
5-Bromo-2,4-difluorobenzaldehyde 98% AS115624 100g $236
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5-Bromo-2,4-difluorobenzaldehyde Properties

Boiling point 229.4±35.0 °C(Predicted)
Density 1.758±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
form fused solid
color Faint lemon

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
HS Code  2913000090

5-Bromo-2,4-difluorobenzaldehyde price More Price(48)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC52118 5-Bromo-2,4-difluorobenzaldehyde 98% 473416-91-0 1g $21 2026-06-04 Buy
Apolloscientific PC52118 5-Bromo-2,4-difluorobenzaldehyde 98% 473416-91-0 1g $21 2026-06-04 Buy
Activate Scientific AS115624 5-Bromo-2,4-difluorobenzaldehyde 98% 473416-91-0 5g $27 2026-06-04 Buy
Activate Scientific AS115624 5-Bromo-2,4-difluorobenzaldehyde 98% 473416-91-0 25g $90 2026-06-04 Buy
Activate Scientific AS115624 5-Bromo-2,4-difluorobenzaldehyde 98% 473416-91-0 100g $236 2026-06-04 Buy
Product number Packaging Price Buy
PC52118 1g $21 Buy
PC52118 1g $21 Buy
AS115624 5g $27 Buy
AS115624 25g $90 Buy
AS115624 100g $236 Buy

5-Bromo-2,4-difluorobenzaldehyde Chemical Properties,Uses,Production

Uses

5-Bromo-2,4-difluorobenzaldehyde is a fluorobenzaldehyde analogue, commonly used as a pharmaceutical intermediate.

Synthesis

1,5-DIBROMO-2,4-DIFLUOROBENZENE

28342-75-8

N,N-Dimethylformamide

68-12-2

5-Bromo-2,4-difluorobenzaldehyde

473416-91-0

General procedure for the synthesis of 5-bromo-2,4-difluorobenzaldehyde from 1,5-dibromo-2,4-difluorobenzene and N,N-dimethylformamide: 1,5-dibromo-2,4-difluorobenzene (17.5 g, 64.2 mmol) was dissolved in ether (100 mL) at -78 °C, and n-butyllithium (2.5 M, 30.8 mL, 77 mmol) was added slowly (2.5 M, 30.8 mL, 77 mmol), over a period of 5 minutes. The reaction mixture was continued to be stirred at -78 °C for 30 min. Subsequently, N,N-dimethylformamide (9.94 mL, 148 mmol) was added all at once and the mixture was stirred at the same temperature for another 30 minutes. After completion of the reaction, the reaction mixture was treated with ethyl acetate and saturated sodium bicarbonate solution. The crude product was purified by silica gel column chromatography using 0-10% ethyl acetate/hexane as eluent to afford the target compound 5-bromo-2,4-difluorobenzaldehyde as a light yellow oil (8.5 g, 60% yield). The product was characterized by 1H NMR (400 MHz, chloroform-d): δ10.26 (s, 1H), 8.14 (t, J=7.5 Hz, 1H), 7.05 (dd, J=9.8,8.0 Hz, 1H).

References

[1] Patent: US2011/9395, 2011, A1. Location in patent: Page/Page column 22
[2] Patent: WO2012/162334, 2012, A1. Location in patent: Page/Page column 38-39
[3] Patent: WO2014/98831, 2014, A1. Location in patent: Page/Page column 27

5-Bromo-2,4-difluorobenzaldehyde Preparation Products And Raw materials

Raw materials

1,5-DIBROMO-2,4-DIFLUOROBENZENE N,N-Dimethylformamide n-Butyllithium Diethyl ether

Preparation Products

5-Bromo-2,4-difluorobenzaldehyde Suppliers

Global( 68)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 factory@coreychem.com China 29792 58
Win-Win chemical CO., Limited 		+86-0086-577-64498589 +86-15355981851 sales@win-winchemical.com China 14303 58
CR Corporation Limited 		fred.wen@crcorporation.cn China 8645 58
Changzhou Anxuan Chemical Co., Ltd 		+86-0519-89882563 +86-18961279162 andy@anxuanchem.com China 4327 58
Labnetwork lnc. 		+86-27-50766799 +86-18062016861 contact@labnetwork.com China 19987 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418684 +86-18949823763 sales@tnjchem.com China 25356 58
Aromsyn Co., Ltd. 		+86-0571-85585865 +86-13336024896 CB@aromsyn.com China 19183 58
Golden Pharma Co., Limited 		+86-18958062155 sales@zjgoldpharm.com China 5899 58
Aceschem Inc. 		+1-817863-6948 +1-（817）863-6948 sales@aceschem.com United States 19632 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 +86-15355479329 market18@leapchem.com China 43333 58
Supplier Advantage
career henan chemical co 		58
Win-Win chemical CO., Limited 		58
CR Corporation Limited 		58
Changzhou Anxuan Chemical Co., Ltd 		58
Labnetwork lnc. 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Aromsyn Co., Ltd. 		58
Golden Pharma Co., Limited 		58
Aceschem Inc. 		58
HANGZHOU LEAP CHEM CO., LTD. 		58

View Lastest Price from 5-Bromo-2,4-difluorobenzaldehyde manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BENZALDEHYDE, 5-BROMO-2,4-DIFLUORO pictures 2020-02-18 BENZALDEHYDE, 5-BROMO-2,4-DIFLUORO
473416-91-0
 $7.00 1KG 99% 100kg Career Henan Chemical Co

5-Bromo-2,4-difluorobenzaldehyde Spectrum

5-Bromo-2,4-difluorobenzaldehyde(473416-91-0)1HNMR

473416-91-0(5-Bromo-2,4-difluorobenzaldehyde)Related Search:

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5-(difluoromethoxy)-2,4-difluorobenzaldehyde 4-Hydroxy-2-methoxybenzaldehyde 4-Chloro-2-iodo-benzaldehyde 5-bromo-4-fluoro-2-methylbenzaldehyde 4-bromo-3-fluoro-5-methylbenzaldehyde
5-Bromo-2-ethylbenzaldehyde 3-BROMO-2,4,5,6-TETRAFLUOROBENZOYL CHLORIDE BENZALDEHYDE, 5-BROMO-2,4-DIFLUORO 3-BROMO-2,4,5-TRIFLUOROBENZOIC ACID

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5-BroMo-2,4-difluorobenzaldehyde BENZALDEHYDE, 5-BROMO-2,4-DIFLUORO 473416-91-0