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5-Bromo-2,4-difluorobenzaldehyde

5-Bromo-2,4-difluorobenzaldehyde Structure
5-Bromo-2,4-difluorobenzaldehyde structure
CAS No.
473416-91-0
Chemical Name:
5-Bromo-2,4-difluorobenzaldehyde
Synonyms
5-BroMo-2,4-difluorobenzaldehyde;BENZALDEHYDE, 5-BROMO-2,4-DIFLUORO;4-(Trifluoromethyl)cinnamoyl chloride
CBNumber:
CB92451672
Molecular Formula:
C7H3BrF2O
Molecular Weight:
221
MDL Number:
MFCD09842439
MOL File:
473416-91-0.mol
MSDS File:
SDS
Last updated:2026-05-28 04:59:19
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5-Bromo-2,4-difluorobenzaldehyde Properties

Boiling point 229.4±35.0 °C(Predicted)
Density 1.758±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
form fused solid
color Faint lemon

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
HS Code  2913000090

5-Bromo-2,4-difluorobenzaldehyde price More Price(42)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC52118 5-Bromo-2,4-difluorobenzaldehyde 98% 473416-91-0 1g $21 2026-06-04 Buy
Activate Scientific AS115624 5-Bromo-2,4-difluorobenzaldehyde 98% 473416-91-0 5g $27 2026-06-04 Buy
Activate Scientific AS115624 5-Bromo-2,4-difluorobenzaldehyde 98% 473416-91-0 25g $90 2026-06-04 Buy
Activate Scientific AS115624 5-Bromo-2,4-difluorobenzaldehyde 98% 473416-91-0 100g $236 2026-06-04 Buy
Matrix Scientific 224331 5-Bromo-2,4-difluorobenzaldehyde 473416-91-0 25.00g $316 2026-05-18 Buy
Product number Packaging Price Buy
PC52118 1g $21 Buy
AS115624 5g $27 Buy
AS115624 25g $90 Buy
AS115624 100g $236 Buy
224331 25.00g $316 Buy

5-Bromo-2,4-difluorobenzaldehyde Chemical Properties, Uses, Production

Uses

5-Bromo-2,4-difluorobenzaldehyde is a fluorobenzaldehyde analogue, commonly used as a pharmaceutical intermediate.

Synthesis

1,5-DIBROMO-2,4-DIFLUOROBENZENE

28342-75-8

N,N-Dimethylformamide

68-12-2

5-Bromo-2,4-difluorobenzaldehyde

473416-91-0

General procedure for the synthesis of 5-bromo-2,4-difluorobenzaldehyde from 1,5-dibromo-2,4-difluorobenzene and N,N-dimethylformamide: 1,5-dibromo-2,4-difluorobenzene (17.5 g, 64.2 mmol) was dissolved in ether (100 mL) at -78 °C, and n-butyllithium (2.5 M, 30.8 mL, 77 mmol) was added slowly (2.5 M, 30.8 mL, 77 mmol), over a period of 5 minutes. The reaction mixture was continued to be stirred at -78 °C for 30 min. Subsequently, N,N-dimethylformamide (9.94 mL, 148 mmol) was added all at once and the mixture was stirred at the same temperature for another 30 minutes. After completion of the reaction, the reaction mixture was treated with ethyl acetate and saturated sodium bicarbonate solution. The crude product was purified by silica gel column chromatography using 0-10% ethyl acetate/hexane as eluent to afford the target compound 5-bromo-2,4-difluorobenzaldehyde as a light yellow oil (8.5 g, 60% yield). The product was characterized by 1H NMR (400 MHz, chloroform-d): δ10.26 (s, 1H), 8.14 (t, J=7.5 Hz, 1H), 7.05 (dd, J=9.8,8.0 Hz, 1H).

References

[1] Patent: US2011/9395, 2011, A1. Location in patent: Page/Page column 22
[2] Patent: WO2012/162334, 2012, A1. Location in patent: Page/Page column 38-39
[3] Patent: WO2014/98831, 2014, A1. Location in patent: Page/Page column 27

5-Bromo-2,4-difluorobenzaldehyde Preparation Products And Raw materials

Raw materials

1,5-Dibromo-2,4-difluorobenzene N,N-Dimethylformamide n-Butyllithium Diethyl ether

Preparation Products

5-Bromo-2,4-difluorobenzaldehyde Suppliers

Global Suppliers ( 69)
Supplier Tel Email Country ProdList Advantage
Wuhan Yuqing Jiaheng Pharmaceutical Co., Ltd 027-83850128 18207128853 3860188266@qq.com China 992 58
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16306 64
Tianjin Jinyuda Chemical Co., Ltd. 022-58013646 13011382049 sales@jinyudachem.com China 1976 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 13913916777 cfzhang@aikonchem.com China 19902 55
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 18201 56
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Changzhou Anxuan Chemical, Co., Ltd. 13912302692 sales@anxuanchem.com China 4824 58
SuZhou ShiYa Biopharmaceuticals, Inc. 0512-0512-52358471 17715136450 sales@shiyabiopharm.com China 9814 58
parabiochem 025-83453382-8005 sale@parabiochem.com China 9577 55
Supplier Advantage
Wuhan Yuqing Jiaheng Pharmaceutical Co., Ltd 58
Energy Chemical 61
Nanjing Chemlin Chemical Co., Ltd 64
Tianjin Jinyuda Chemical Co., Ltd. 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 55
9ding chemical ( Shanghai) Limited 56
Bide Pharmatech Ltd. 60
Changzhou Anxuan Chemical, Co., Ltd. 58
SuZhou ShiYa Biopharmaceuticals, Inc. 58
parabiochem 55

View Latest Price from 5-Bromo-2,4-difluorobenzaldehyde manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BENZALDEHYDE, 5-BROMO-2,4-DIFLUORO pictures 2020-02-18 BENZALDEHYDE, 5-BROMO-2,4-DIFLUORO
473416-91-0
 $7.00 1KG 99% 100kg Career Henan Chemical Co

5-Bromo-2,4-difluorobenzaldehyde Spectrum

5-Bromo-2,4-difluorobenzaldehyde(473416-91-0)1HNMR

473416-91-0 (5-Bromo-2,4-difluorobenzaldehyde) Related Search:

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5-BroMo-2,4-difluorobenzaldehyde BENZALDEHYDE, 5-BROMO-2,4-DIFLUORO 4-(Trifluoromethyl)cinnamoyl chloride 473416-91-0