(S)-Methyl pyrrolidine-3-carboxylate hydrochloride
- CAS No.
- 1099646-61-3
- Chemical Name:
- (S)-Methyl pyrrolidine-3-carboxylate hydrochloride
- Synonyms
- (S)-Methyl pyrrolidine-3-...;methyl(R)-pyrrolidine-3-carboxylatehydrochloride;S-3-Pyrrolidinecarboxylic acid methyl ester HCL;(3S)-3-PYRROLIDINECARBOXYLIC ACID METHYL ESTER HCL;Methyl (3S)-3-pyrrolidinecarboxylate hydrochloride;(S)-Methyl pyrrolidine-3-carboxylate hydrochloride;(3S)-Pyrrolidine-3-carboxylic acid methyl ester HCl;methyl (3S)-pyrrolidine-3-carboxylate hydrochloride;S-3-Pyrrolidinecarboxylic acid Methyl ester hydrochloride;3-Pyrrolidinecarboxylic acid, Methyl ester, hydrochloride, (3S)-
- CBNumber:
- CB92464863
- Molecular Formula:
- C6H12ClNO2
- Molecular Weight:
- 165.62
- MDL Number:
- MFCD11840196
- MOL File:
- 1099646-61-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H302 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501 |
| HS Code | 2933998090 |
(S)-Methyl pyrrolidine-3-carboxylate hydrochloride price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR925582 | (S)-Methyl pyrrolidine-3-carboxylate hydrochloride 98% | 1099646-61-3 | 100mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR925582 | (S)-Methyl pyrrolidine-3-carboxylate hydrochloride 98% | 1099646-61-3 | 250mg | $32 | 2026-06-04 | Buy |
| Apolloscientific | OR925582 | (S)-Methyl pyrrolidine-3-carboxylate hydrochloride 98% | 1099646-61-3 | 1g | $55 | 2026-06-04 | Buy |
| Apolloscientific | OR925582 | (S)-Methyl pyrrolidine-3-carboxylate hydrochloride 98% | 1099646-61-3 | 5g | $195 | 2026-06-04 | Buy |
| Apolloscientific | OR925582 | (S)-Methyl pyrrolidine-3-carboxylate hydrochloride 98% | 1099646-61-3 | 25g | $844 | 2026-06-04 | Buy |
(S)-Methyl pyrrolidine-3-carboxylate hydrochloride Chemical Properties, Uses, Production
Uses
(S)-Methyl Pyrrolidine-3-carboxylate Hydrochloride is a reagent involved in the discovery of a new small molecule agonist scaffold for the APJ receptor, which may help treat cardiovascular diseases and other disorders.
Synthesis
67-56-1
140148-70-5
1099646-61-3
The general procedure for the synthesis of methyl S-pyrrolidine-3-carboxylate hydrochloride from methanol and (S)-1-BOC-pyrrolidine-3-carboxylic acid was as follows: to a stirred solution of (3S)-1-{[(1,1-dimethylethyl)oxy]carbonyl}-3-pyrrolidinecarboxylic acid (1.0 g, 4.6 mmol) in methanol (25 mL) was slowly added dropwise, protected by nitrogen and at room temperature, to a stirred solution of Thionyl chloride (1.63 g, 13.7 mmol). The reaction mixture was heated to reflux for 2 hours and subsequently cooled to room temperature. The reaction mixture was concentrated to give 0.766 g (100% yield) of methyl(3S)-3-pyrrolidinecarboxylic acid hydrochloride, initially as an oil, which solidified on standing. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 9.91 (m, 2H), 3.76 (s, 3H), 3.59 (br s, 2H), 3.49 (br s, 2H), 3.28 (br s, 1H), 2.33 (br s, 2H).
References
[1] Patent: WO2009/5998, 2009, A1. Location in patent: Page/Page column 252-253
(S)-Methyl pyrrolidine-3-carboxylate hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-Methyl pyrrolidine-3-carboxylate hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
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