Lecozotan hydrochloride
- CAS No.
- 433282-68-9
- Chemical Name:
- Lecozotan hydrochloride
- Synonyms
- Sra-333;Sra 333;Lecozotan sr;Lecozotan HCl;Lecozotan hydrochloride;Benzamide, 4-cyano-N-((2R)-2-(4-(2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl)propyl)-N-2-pyridinyl-, monohydrochloride;Benzamide, 4-cyano-N-[(2R)-2-[4-(2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl]propyl]-N-2-pyridinyl-, hydrochloride (1:1)
- CBNumber:
- CB92491997
- Molecular Formula:
- C28H29N5O3.ClH
- Molecular Weight:
- 520.02
- MDL Number:
- MFCD11100262
- MOL File:
- 433282-68-9.mol
- MSDS File:
- SDS
| Melting point | 239-240 °C |
|---|---|
| form | Solid |
| color | Off-white to light yellow |
| FDA UNII | 23EDE20K1X |
Lecozotan hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0016555 | Lecozotan hydrochloride 98.71% | 433282-68-9 | 1mg | $184 | 2026-06-04 | Buy |
| ChemScene | CS-0016555 | Lecozotan hydrochloride 98.71% | 433282-68-9 | 5mg | $444 | 2026-06-04 | Buy |
| ChemScene | CS-0016555 | Lecozotan hydrochloride 98.71% | 433282-68-9 | 10mg | $704 | 2026-06-04 | Buy |
| aablocks | AA01OOCN | Lecozotan HCl | 433282-68-9 | 1mg | $132 | 2026-05-31 | Buy |
| aablocks | AA01OOCN | Lecozotan HCl | 433282-68-9 | 5mg | $291 | 2026-05-31 | Buy |
Lecozotan hydrochloride Chemical Properties, Uses, Production
Description
Lecozotan HCl (SRA-333) is a potent and selective 5-HT antagonist that significantly enhances KCl-stimulated glutamate and acetylcholine release from the hippocampal dentate gyrus and has cognitive enhancing properties. Chronic administration of Lecozotan HCl did not induce 5-HT(1A) receptor tolerance or desensitization in a behavioral model demonstrating 5-HT(1A) receptor function.
Uses
Treatment of cognitive deficits associated with Alzheimer’s disease (5-HT1A receptor antagonist).
IC 50
5-HT1A Receptor: 4.5 nM (Ki)
References
[1] WAYNE E. CHILDERS. Synthesis and Biological Evaluation of Benzodioxanylpiperazine Derivatives as Potent Serotonin 5-HT1A Antagonists: The Discovery of Lecozotan[J]. Journal of Medicinal Chemistry, 2005, 48 10: 3467-3470. DOI:10.1021/jm049493z.
[2] L E SCHECHTER. Lecozotan (SRA-333): a selective serotonin 1A receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties.[J]. Journal of Pharmacology and Experimental Therapeutics, 2005, 314 3: 1274-1289. DOI:10.1124/jpet.105.086363.
[3] KEVIN BOOTH. P3-425: Safety, tolerability and efficacy of lecozotan SR in patients with mild-to-moderate Alzheimer’s disease used as monotherapy or adjunctively with a cholinesterase inhibitor[J]. Alzheimer’s & Dementia, 2012, 8 4S_Part_16: P604. DOI:10.1016/j.jalz.2012.05.2099.
[4] MIGUEL SKIRZEWSKI . Acute lecozotan administration increases learning and memory in rats without affecting anxiety or behavioral depression[J]. Pharmacology Biochemistry and Behavior, 2010, 95 3: Pages 325-330. DOI:10.1016/j.pbb.2010.02.008.
Lecozotan hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Lecozotan hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Suzhou Meishi Biotechnology Co., Ltd. | 1173954148q | meishipharma@126.com | China | 20027 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +86-15965530500 | nickzhang@hangyubiotech.com | China | 9929 | 58 |
View Latest Price from Lecozotan hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Lecozotan HCl
433282-68-9
|
$139.00-538.00 | 99.04% | 10g | TargetMol Chemicals Inc. |
-
- Lecozotan HCl
433282-68-9
- $139.00-538.00
- 99.04%
- TargetMol Chemicals Inc.
