Lecozotan hydrochloride manufacturers
- Lecozotan HCl
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- $139.00
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2026-07-27
- CAS:433282-68-9
- Purity: 99.04%
- Supply Ability: 10g
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| | Lecozotan hydrochloride Basic information |
| Product Name: | Lecozotan hydrochloride | | Synonyms: | Benzamide, 4-cyano-N-((2R)-2-(4-(2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl)propyl)-N-2-pyridinyl-, monohydrochloride;Lecozotan HCl;Lecozotan hydrochloride;Lecozotan sr;Sra 333;Sra-333;Benzamide, 4-cyano-N-[(2R)-2-[4-(2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl]propyl]-N-2-pyridinyl-, hydrochloride (1:1) | | CAS: | 433282-68-9 | | MF: | C28H29N5O3.ClH | | MW: | 520.02 | | EINECS: | | | Product Categories: | | | Mol File: | 433282-68-9.mol |  |
| | Lecozotan hydrochloride Chemical Properties |
| Melting point | 239-240 °C | | form | Solid | | color | Off-white to light yellow |
| | Lecozotan hydrochloride Usage And Synthesis |
| Description | Lecozotan HCl (SRA-333) is a potent and selective 5-HT antagonist that significantly enhances KCl-stimulated glutamate and acetylcholine release from the hippocampal dentate gyrus and has cognitive enhancing properties. Chronic administration of Lecozotan HCl did not induce 5-HT(1A) receptor tolerance or desensitization in a behavioral model demonstrating 5-HT(1A) receptor function. | | Uses | Treatment of cognitive deficits associated with Alzheimer’s disease (5-HT1A
receptor antagonist). | | IC 50 | 5-HT1A Receptor: 4.5 nM (Ki) | | References | [1] WAYNE E. CHILDERS. Synthesis and Biological Evaluation of Benzodioxanylpiperazine Derivatives as Potent Serotonin 5-HT1A Antagonists: The Discovery of Lecozotan[J]. Journal of Medicinal Chemistry, 2005, 48 10: 3467-3470. DOI:10.1021/jm049493z.
[2] L E SCHECHTER. Lecozotan (SRA-333): a selective serotonin 1A receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties.[J]. Journal of Pharmacology and Experimental Therapeutics, 2005, 314 3: 1274-1289. DOI:10.1124/jpet.105.086363.
[3] KEVIN BOOTH. P3-425: Safety, tolerability and efficacy of lecozotan SR in patients with mild-to-moderate Alzheimer’s disease used as monotherapy or adjunctively with a cholinesterase inhibitor[J]. Alzheimer’s & Dementia, 2012, 8 4S_Part_16: P604. DOI:10.1016/j.jalz.2012.05.2099.
[4] MIGUEL SKIRZEWSKI . Acute lecozotan administration increases learning and memory in rats without affecting anxiety or behavioral depression[J]. Pharmacology Biochemistry and Behavior, 2010, 95 3: Pages 325-330. DOI:10.1016/j.pbb.2010.02.008. |
| | Lecozotan hydrochloride Preparation Products And Raw materials |
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