Sarizotan
- CAS No.
- 351862-32-3
- Chemical Name:
- Sarizotan
- Synonyms
- Sarizotan free base;Rotigotine Impurity 26-d3;(R)-1-(Chroman-2-yl)-N-((5-(4-fluorophenyl)pyridin-3-yl)methyl)methanamine;3-Pyridinemethanamine, N-[[(2R)-3,4-dihydro-2H-1-benzopyran-2-yl]methyl]-5-(4-fluorophenyl)-
- CBNumber:
- CB92498840
- Molecular Formula:
- C22H21FN2O
- Molecular Weight:
- 348.41
- MDL Number:
- MOL File:
- 351862-32-3.mol
- MSDS File:
- SDS
| Boiling point | 507.7±45.0 °C(Predicted) |
|---|---|
| Density | 1.172±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 100 mg/mL (287.02 mM; Need ultrasonic) |
| form | Viscous Liquid |
| pka | 7.01±0.20(Predicted) |
| color | Colorless to light yellow |
| FDA UNII | 467LU0UCUW |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
Sarizotan price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0020461 | Sarizotan 98.23% | 351862-32-3 | 5mg | $271 | 2026-06-04 | Buy |
| ChemScene | CS-0020461 | Sarizotan 98.23% | 351862-32-3 | 10mg | $412 | 2026-06-04 | Buy |
| ChemScene | CS-0020461 | Sarizotan 98.23% | 351862-32-3 | 25mg | $812 | 2026-06-04 | Buy |
| ChemScene | CS-0020461 | Sarizotan 98.23% | 351862-32-3 | 50mg | $1300 | 2026-06-04 | Buy |
| ChemScene | CS-0020461 | Sarizotan 98.23% | 351862-32-3 | 100mg | $2112 | 2026-06-04 | Buy |
Sarizotan Chemical Properties, Uses, Production
Uses
Treatment—associated dyskinesia in Parkinson’s disease.
in vivo
Sarizotan (3, 10 mg/kg, po) at the higher dose slightly decreases 5-HT in the striatum and its metabolite 5-HIAA in frontal cortex and hippocampus. Sarizotan (10 mg/kg, po) substantially increases the DA metabolites DOPAC and HVA in the striatum and frontal cortex[1].
Sarizotan represents a new approach for the treatment of extrapyramidal motor complications such as l-DOPA-induced dyskinesia in Parkinson’s disease[1].
Sarizotan (10 ng and 1 μg, local administration) attenuates levodopa-induced dyskinesias in 6-OHDA-lesioned rats[2].
| Animal Model: | Male Sprague-Dawley rats weighing 220-240 g (exhibiting a vigorous rotational response)[2]. |
| Dosage: | 1 ng, 10 ng and 1 μg in 0.3 μL solution. |
| Administration: | Administered via an injection cannula inserted to the guide cannula through the STN (V -8.4 mm from skull) with the injection cannula connected to a 10-μL syringe and mounted on a microinfusion pump for 22 consecutive days. |
| Result: | On day 23, the subthalamic administration of Sarizotan at the higher doses tested (10 ng and 1 μg) significantly decreased the total dyskinesia score in levodopa-treated rats in comparison with the rats treated only with levodopa (p<0.05, p<0.01, respectively). |
IC 50
5-HT1A Receptor: 6.5 nM (IC50, rat); 5-HT1A Receptor: 0.1 nM (IC50, human); rD2 Receptor: 15.1 nM (IC50, rat); D3 Receptor: 6.8 nM (IC50, human); 5-HT1B Receptor: 600 nM (IC50, rat); 5-HT1D Receptor: 500 nM (IC50, calf); 5-HT2A Receptor: 960 nM (IC50, rat, agonist site); 5-HT2A Receptor: 587 nM (IC50, human, antagonist site); 5-HT2B Receptor: 108 nM (IC50, human); 5-HT2C Receptor: 800 nM (IC50, pig); 5-HT3 Receptor: 3500 nM (IC50, NG 108 cells); 5-HT5A Receptor: 313 nM (IC50, human); 5-HT6 Receptor: 3300 nM (IC50, human); 5-HT7 Receptor: 10 nM (IC50, human); hD4.2 Receptor: 2.4 nM (IC50); hD2 Receptor: 17 nM (IC50)
Sarizotan Preparation Products And Raw materials
Raw materials
Preparation Products
Sarizotan Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 18100677375 | sales@szzxbio.com | China | 1129 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Shanghai Anbida Biotechnology Co., Ltd. | 021-61629020 18201956406 | sales@ambeed.cn | China | 7032 | 58 |
