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ChemicalBook >> CAS DataBase List >>N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride Structure
N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride structure
CAS No.
478149-53-0
Chemical Name:
N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride
Synonyms
PHA-543613;PHA-543613 >=98% (HPLC);PHA 543613 hydrochloride;PHA 543613, 10 mM in DMSO;PHA-543,613 - CAS 478149-53-0 - Calbiochem;(R)-N-(quinuclidin-3-yl)furo[2,3-c]pyridine-5-carboxaMide;N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide;Furo[2,3-c]pyridine-5-carboxamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-;N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]furo[2,3-c]pyridine-5-carboxamide;N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamidehydrochloride
CBNumber:
CB92503302
Molecular Formula:
C15H17N3O2
Molecular Weight:
271.31
MDL Number:
MFCD12828748
MOL File:
478149-53-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-09 20:17:37
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N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride Properties

Melting point 313-315 °C
Boiling point 508.0±40.0 °C(Predicted)
Density 1.32±0.1 g/cm3(Predicted)
storage temp. Store at +4°C
solubility DMSO: ≥20mg/mL
form White powder
pka 12.19±0.20(Predicted)
color white to off-white
InChI 1S/C15H17N3O2/c19-15(12-7-11-3-6-20-14(11)8-16-12)17-13-9-18-4-1-10(13)2-5-18/h3,6-8,10,13H,1-2,4-5,9H2,(H,17,19)/t13-/m0/s1
InChIKey IPKZCLGGYKRDES-ZDUSSCGKSA-N
SMILES O=C(N[C@H]1CN2CC[C@H]1CC2)c3cc4ccoc4cn3
FDA UNII R36R9KVD6Y
UNSPSC Code 51111800
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P
WGK Germany  1
Storage Class 11 - Combustible Solids

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PZ0135 PHA-543613 ≥98% (HPLC) 478149-53-0 5mg $170 2026-04-30 Buy
Sigma-Aldrich PZ0135 PHA-543613 ≥98% (HPLC) 478149-53-0 25mg $637 2026-04-30 Buy
Sigma-Aldrich 5.05316 PHA-543,613 - CAS 478149-53-0 - Calbiochem 478149-53-0 5MG $179 2022-05-15 Buy
Cayman Chemical 42222 PHA-543613 ≥95% 478149-53-0 5mg $138 2026-04-30 Buy
Cayman Chemical 42222 PHA-543613 ≥95% 478149-53-0 10mg $235 2026-04-30 Buy
Product number Packaging Price Buy
PZ0135 5mg $170 Buy
PZ0135 25mg $637 Buy
5.05316 5MG $179 Buy
42222 5mg $138 Buy
42222 10mg $235 Buy

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride Chemical Properties,Uses,Production

Uses

PHA-543613 has been used to study its effect on recognition memory and neurovascular coupling (NVC) response in β-amyloid (Aβ) 25-35-treated mice. It has also been used to study its effect on Aβ25-35-induced receptor alteration and cognitive impairment in mice.

Definition

ChEBI: Pha-543613 is a phosphoramide and an organothiophosphorus compound.

Biological Activity

Primary Target
α7 nAChR

in vivo

PHA-543613 (0.3 mg/kg) successfully reverses Scopolamine-induced short-term memory deficits in rats[2]. PHA-543613 (4 and 12 mg/kg; i.p. once) reduces behavioral deficits and brain edema[3].

Animal Model:Male CD-1 mice with (intracerebral hemorrhage) ICH-induction or sham surgery[3]
Dosage:4 and 12 mg/kg
Administration:Intraperitoneal injection; 4 and 12 mg/kg; 1 hour after surgery
Result:Increased p-Akt and decreased p-GSK-3 and CC3 expressions in the ipsilateral hemisphere and reduced the neuronal cell death in the perihematomal area. Attenuated behavioral deficits and brain edema at 72 hours after ICH.

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride Suppliers

Global( 35)Suppliers
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Syntechem Co.,Ltd info@syntechem.com China 12973 57
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123 sj_scrc@sinopharm.com China 9791 79
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4861 55
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8435 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai Rechem science Co., Ltd. 021-31433387 15618786686 sales@rechemscience.com China 2971 58
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9699 58
Wellman Pharmaceutical Group Limited 15807197853 18971451745 15807197853@163.com China 3968 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Syntechem Co.,Ltd 57
Sinopharm Chemical Reagent Co,Ltd. 79
Shanghai Lollane Biological Technology Co.,Ltd. 55
EMMX Biotechnology LLC 60
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai Rechem science Co., Ltd. 58
Shanghai Chaolan Chemical Technology Center 58
Wellman Pharmaceutical Group Limited 58
TargetMol Chemicals Inc. 58

View Lastest Price from N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PHA 543613 pictures 2026-07-10 PHA 543613
478149-53-0
 1KG 98% 20Tons Shaanxi Dideu New Materials Co. Ltd
PHA 543613 pictures 2026-05-25 PHA 543613
478149-53-0
 $46.00-178.00 99.96% 10g TargetMol Chemicals Inc.
  • PHA 543613 pictures
  • PHA 543613
    478149-53-0
  • 98%
  • Shaanxi Dideu New Materials Co. Ltd
  • PHA 543613 pictures
  • PHA 543613
    478149-53-0
  • $46.00-178.00
  • 99.96%
  • TargetMol Chemicals Inc.

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride Spectrum

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride(478149-53-0)1HNMR

478149-53-0(N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride)Related Search:

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PHA-543,613 - CAS 478149-53-0 - Calbiochem N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamidehydrochloride PHA 543613 hydrochloride PHA-543613 (R)-N-(quinuclidin-3-yl)furo[2,3-c]pyridine-5-carboxaMide N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxaMide hydrochlorid N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]furo[2,3-c]pyridine-5-carboxamide N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride Furo[2,3-c]pyridine-5-carboxamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl- PHA-543613 >=98% (HPLC) PHA 543613, 10 mM in DMSO 478149-53-0 C15H17N3O22HCl