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3-Bromo-4-methyl-5-nitropyridine

3-Bromo-4-methyl-5-nitropyridine Structure
3-Bromo-4-methyl-5-nitropyridine structure
CAS No.
69872-15-7
Chemical Name:
3-Bromo-4-methyl-5-nitropyridine
Synonyms
3-Bromo-4-methy-5nitro-pyridine;3-Bromo-4-methyl-5-nitropyridine;4-Methyl-5-Bromo-3-Nitropyridine;Pyridine, 3-bromo-4-methyl-5-nitro-;3-Bromo-4-methyl-5-nitropyridine ISO 9001：2015 REACH
CBNumber:
CB92516230
Molecular Formula:
C6H5BrN2O2
Molecular Weight:
217.02
MDL Number:
MFCD11847767
MOL File:
69872-15-7.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:51
Product description Number Pack Size Price
3-Bromo-4-methyl-5-nitropyridine B808055 500mg $90
3-Bromo-4-methyl-5-nitropyridine FB143819 5G $250
3-Bromo-4-methyl-5-nitropyridine 97.61% CS-W003806 25g $295
3-Bromo-4-methyl-5-nitropyridine 95+% 076300 5g $373
3-Bromo-4-methyl-5-nitropyridine FB143819 10g $400
More product size
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3-Bromo-4-methyl-5-nitropyridine Properties

Melting point 57-58℃
Boiling point 269℃
Density 1.709
Flash point 116℃
storage temp. Sealed in dry,Room Temperature
pka -0.51±0.28(Predicted)
Appearance Off-white to light yellow Solid
InChI InChI=1S/C6H5BrN2O2/c1-4-5(7)2-8-3-6(4)9(10)11/h2-3H,1H3
InChIKey WFCIQRPATFRBOY-UHFFFAOYSA-N
SMILES C1=NC=C([N+]([O-])=O)C(C)=C1Br

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335-H302
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501

3-Bromo-4-methyl-5-nitropyridine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC B808055 3-Bromo-4-methyl-5-nitropyridine 69872-15-7 500mg $90 2021-12-16 Buy
Biosynth Carbosynth FB143819 3-Bromo-4-methyl-5-nitropyridine 69872-15-7 5G $250 2021-12-16 Buy
ChemScene CS-W003806 3-Bromo-4-methyl-5-nitropyridine 97.61% 69872-15-7 25g $295 2021-12-16 Buy
Matrix Scientific 076300 3-Bromo-4-methyl-5-nitropyridine 95+% 69872-15-7 5g $373 2021-12-16 Buy
Biosynth Carbosynth FB143819 3-Bromo-4-methyl-5-nitropyridine 69872-15-7 10g $400 2021-12-16 Buy
Product number Packaging Price Buy
B808055 500mg $90 Buy
FB143819 5G $250 Buy
CS-W003806 25g $295 Buy
076300 5g $373 Buy
FB143819 10g $400 Buy

3-Bromo-4-methyl-5-nitropyridine Chemical Properties,Uses,Production

Uses

3-Bromo-4-methyl-5-nitropyridine is an intermediate used in the synthesis of 4-bromo-6-azaindole and other azaindole derivatives.

Synthesis

3-BROMO-4-CHLORO-5-NITROPYRIDINE

31872-63-6

Diethyl malonate

105-53-3

3-Bromo-4-methyl-5-nitropyridine

69872-15-7

GENERAL STEPS: Diethyl malonate (3.84 mL, 25.3 mmol) was slowly added dropwise to a suspension of sodium hydride (1.01 g, 60% oil suspension, 25.3 mmol) in DMF (15 mL) at 0 °C and stirred for 30 min until gas escape ceased. Subsequently, 3-bromo-4-chloro-5-nitropyridine (3.00 g, 12.6 mmol) was slowly added and the resulting dark reddish brown solution was stirred for 1 hour at room temperature. Upon completion of the reaction, it was carefully quenched with water and the pH was adjusted to 1 with 1 N HCl. The aqueous phase was extracted with EtOAc (2 x 150 mL), the organic phases were combined and washed with deionized water (100 mL) and saturated saline, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was dissolved in 4N HCl (50 mL) and refluxed for 16 hours. The reaction mixture was cooled in an ice bath and neutralized with 50% NaOH solution to pH 7. The aqueous phase was again extracted with EtOAc (3 x 100 mL), the organic phases were combined and washed with saturated saline, dried over MgSO4, filtered and concentrated under reduced pressure to afford the target product 3-bromo-4-methyl-5-nitropyridine (94a, 1.90 g, 70% yield) as a yellow solid. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 8.94 (s, 1H), 8.97 (s, 1H), 2.65 (s, 3H).

References

[1] Journal of Medicinal Chemistry, 2014, vol. 57, # 6, p. 2462 - 2471
[2] Patent: US2005/90529, 2005, A1. Location in patent: Page/Page column 82

3-Bromo-4-methyl-5-nitropyridine synthesis

31872-63-6
105-53-3
69872-15-7
Synthesis of 3-Bromo-4-methyl-5-nitropyridine from 3-BROMO-4-CHLORO-5-NITROPYRIDINE and Diethyl malonate

3-Bromo-4-methyl-5-nitropyridine Preparation Products And Raw materials

Raw materials

Diethyl (3-bromo-5-nitropyridin-4-yl)malonate 3-Bromo-4-hydroxy-5-nitropyridine 3-BROMO-4-CHLORO-5-NITROPYRIDINE Diethyl malonate Sodium hydride
N,N-Dimethylformamide 4-Hydroxy-3-nitropyridine

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Preparation Products

4-bromo-1H-pyrrolo[2,3-c]pyridine

3-Bromo-4-methyl-5-nitropyridine Suppliers

Global( 127)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29734 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29852 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23541 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 20342 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52846 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Hubei xin bonus chemical co. LTD 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
ANHUI WITOP BIOTECH CO., LTD 		58
Dideu Industries Group Limited 		58
Hefei Hirisun Pharmatech Co., Ltd 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58

View Lastest Price from 3-Bromo-4-methyl-5-nitropyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Bromo-4-methyl-5-nitropyridine pictures 2025-07-25 3-Bromo-4-methyl-5-nitropyridine
69872-15-7
 US $0.00 / kg 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
3-Bromo-4-methyl-5-nitropyridine pictures 2025-07-25 3-Bromo-4-methyl-5-nitropyridine
69872-15-7
 US $0.00 / kg 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
3-Bromo-4-methyl-5-nitropyridine pictures 2021-09-23 3-Bromo-4-methyl-5-nitropyridine
69872-15-7
 US $1.10 / g 1g 99.00% 100 Tons min Dideu Industries Group Limited

3-Bromo-4-methyl-5-nitropyridine Spectrum

3-Bromo-4-methyl-5-nitropyridine(69872-15-7)1HNMR

69872-15-7(3-Bromo-4-methyl-5-nitropyridine)Related Search:

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3-Bromo-4-methyl-5-nitropyridine 3-Bromo-4-methy-5nitro-pyridine Pyridine, 3-bromo-4-methyl-5-nitro- 3-Bromo-4-methyl-5-nitropyridine ISO 9001：2015 REACH 4-Methyl-5-Bromo-3-Nitropyridine 69872-15-7 Heterocycle-Pyridine series