4-Hydroxy-2,6-dimethylpyridine
- CAS No.
- 13603-44-6
- Chemical Name:
- 4-Hydroxy-2,6-dimethylpyridine
- Synonyms
- 2,6-Dimethyl-4-pyridinol;2,6-DIMETHYL-PYRIDIN-4-OL;2,6-Dimethylpyridine-4-ol;4-PYRIDINOL, 2,6-DIMETHYL-;4-HYDROXY-2,6-DIMETHYLPYRIDINE;2,6-DIMETHYL-4-HYDROXYPYRIDINE;2,6-Dimethyl-4-hydroxypyridine>2,6-Dimethyl-4-hydroxypyridine 98%;2,6- two methyl -4- hydroxypyridine;2,6-Dimethyl-4-hydroxypyridine ,98%
- CBNumber:
- CB2345053
- Molecular Formula:
- C7H9NO
- Molecular Weight:
- 123.15
- MDL Number:
- MFCD00956021
- MOL File:
- 13603-44-6.mol
- MSDS File:
- SDS
| Melting point | 230-232°C |
|---|---|
| Boiling point | 351 °C |
| Density | 1,053g/cm |
| refractive index | 1,501-1,503 |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly, Heated), Methanol (Slightly) |
| form | Solid |
| pka | 5.49±0.23(Predicted) |
| color | White to Off-White |
| InChI | InChI=1S/C7H9NO/c1-5-3-7(9)4-6(2)8-5/h3-4H,1-2H3,(H,8,9) |
| InChIKey | PRAFLUMTYHBEHE-UHFFFAOYSA-N |
| SMILES | C1(C)=NC(C)=CC(O)=C1 |
| LogP | 0.190 (est) |
| CAS DataBase Reference | 13603-44-6(CAS DataBase Reference) |
| FDA UNII | 92JKJ9S198 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-36/37/39 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333990 | |||||||||
| NFPA 704 |
|
4-Hydroxy-2,6-dimethylpyridine price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D3638 | 2,6-Dimethyl-4-hydroxypyridine >98.0%(GC) | 13603-44-6 | 1g | $34 | 2026-04-30 | Buy |
| TCI Chemical | D3638 | 2,6-Dimethyl-4-hydroxypyridine >98.0%(GC) | 13603-44-6 | 5g | $168 | 2026-04-30 | Buy |
| TRC | TRC-D473270-5G | 2,6-Dimethyl-4-hydroxypyridine | 13603-44-6 | 5g | $205 | 2026-06-03 | Buy |
| TRC | TRC-D473270-25G | 2,6-Dimethyl-4-hydroxypyridine | 13603-44-6 | 25g | $403 | 2026-06-03 | Buy |
| TRC | TRC-D473270-2.5G | 2,6-Dimethyl-4-hydroxypyridine | 13603-44-6 | 2.5g | $154 | 2026-06-03 | Buy |
4-Hydroxy-2,6-dimethylpyridine Chemical Properties, Uses, Production
Chemical Properties
Yellow to Brown Cryst
Uses
2,6-Dimethyl-4-hydroxypyridine is a useful synthetic intermediate. It is used in the synthesis of disubstituted pyridinyl-aminohydantoins as selective human BACE1 inhibitors.
Synthesis
520-45-6
13603-44-6
The general procedure for the synthesis of 2,6-dimethyl-4-hydroxypyridine from dehydroacetic acid was as follows: five different batches of dehydroacetic acid (1.5 g, 8.92 mmol) were suspended in concentrated ammonia (4 mL) and placed in a microwave reactor (Discover system, 150 W, CEM Corporation, Matthews, North Carolina, USA) and microwave irradiated at 120°C for 20 min. Upon completion of the reaction, the reaction mixture was cooled and all batches were combined and subsequently evaporated to dryness to afford the target product 2,6-dimethyl-4-hydroxypyridine. The mass of the product was 5.91 g (108% yield), which was analyzed by LC/MS showing a purity of 73%. Unreacted dehydroacetic acid was present as a residual mass balance.The LC/MS retention time was 0.67 min and the mass spectrum (ES+) showed m/z 168 (M + CH3CN + H).
References
[1] Patent: WO2008/57497, 2008, A2. Location in patent: Page/Page column 252-253
[2] Patent: WO2008/57469, 2008, A1. Location in patent: Page/Page column 252-253
[3] Patent: WO2008/57468, 2008, A1. Location in patent: Page/Page column 252-253
[4] Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1988, vol. 42, # 6, p. 373 - 377
[5] Chemische Berichte, 1887, vol. 20, p. 159
4-Hydroxy-2,6-dimethylpyridine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Yanji Biotechnology Co., Ltd. | 0519-83556355 18015005120 | shikewei397@163.com | China | 3732 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Changzhou Huanling Chemical Co., Ltd. | 89803005 18206112582 | info@huanlingchem.com | China | 983 | 68 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
View Latest Price from 4-Hydroxy-2,6-dimethylpyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 4-Hydroxy-2,6-dimethylpyridine
13603-44-6
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-04-20 | 4-Hydroxy-2,6-dimethylpyridine
13603-44-6
|
10g | TargetMol Chemicals Inc. | ||||
 |
2026-03-20 | 4-Hydroxy-2,6-dimethylpyridine
13603-44-6
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 4-Hydroxy-2,6-dimethylpyridine
13603-44-6
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 4-Hydroxy-2,6-dimethylpyridine
13603-44-6
- TargetMol Chemicals Inc.
-
- 4-Hydroxy-2,6-dimethylpyridine
13603-44-6
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
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