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(R)-(+)-THALIDOMIDE

(R)-(+)-THALIDOMIDE structure

CAS No.: 2614-06-4

Chemical Name:: (R)-(+)-THALIDOMIDE

Synonyms: NSC 91729;(+)-Thalidomide;(R)-(+)-THALIDOMIDE;Thalidomide (R)-Isomer;6-dioxo-3-piperidyl)-n-(d-(+)-phthalimid;N-[(R)-2,6-Dioxopiperidine-3-yl]phthalimide;(+)-N-[(R)-2,6-Dioxo-3-piperidinyl]phthalimide;2-[(3R)-2,6-dioxopiperidin-3-yl]isoindole-1,3-dione;6-dioxo-3-piperidinyl)-3(2h)-dion(r)-1h-isoindole-2-(2;(3R)-3-(1,3-Dioxo-2H-isoindole-2-yl)piperidine-2,6-dione

CBNumber:: CB9251689

Molecular Formula:: C13H10N2O4

Molecular Weight:: 258.23

MDL Number:: MFCD00210220

MOL File:: 2614-06-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-27 17:00:41

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(R)-(+)-THALIDOMIDE Properties

Melting point	269-271°C
Boiling point	401.48°C (rough estimate)
Density	1.2944 (rough estimate)
refractive index	1.5300 (estimate)
storage temp.	-20°C Freezer
solubility	DMSO: soluble
form	solid
pka	10.70±0.40(Predicted)
color	white
InChI	1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)/t9-/m1/s1
InChIKey	UEJJHQNACJXSKW-SECBINFHSA-N
SMILES	O=C1CC[C@@H](N2C(=O)c3ccccc3C2=O)C(=O)N1
FDA UNII	QN61H68KLK
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08
Signal word	Danger
Hazard statements	H302-H360
Precautionary statements	P201-P301+P312+P330-P308+P313
PPE	Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Hazard Codes	T
Risk Statements	61-22
Safety Statements	53-36/37/39-45
WGK Germany	3
RTECS	TI4925000
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 4 Oral Repr. 1B

(R)-(+)-THALIDOMIDE price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T151	(+)-Thalidomide ≥98%(HPLC),powder	2614-06-4	10mg	$142	2026-04-30	Buy
Sigma-Aldrich	T151	(+)-Thalidomide ≥98%(HPLC),powder	2614-06-4	100mg	$910	2026-04-30	Buy
TRC	TRC-T338855-25MG	(R)-(+)-Thalidomide	2614-06-4	25mg	$1528	2026-06-03	Buy
TRC	TRC-T338855-2.5MG	(R)-(+)-Thalidomide	2614-06-4	2.5mg	$193	2026-06-03	Buy
TRC	TRC-T338855-10MG	(R)-(+)-Thalidomide	2614-06-4	10mg	$746	2026-06-03	Buy

Product number	Packaging	Price	Buy
T151	10mg	$142	Buy
T151	100mg	$910	Buy
TRC-T338855-25MG	25mg	$1528	Buy
TRC-T338855-2.5MG	2.5mg	$193	Buy
TRC-T338855-10MG	10mg	$746	Buy

(R)-(+)-THALIDOMIDE Chemical Properties,Uses,Production

Chemical Properties

Needles

Uses

Optically active isomer of Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative.

Uses

Thalidomide has been used to study its teratogenic effects in chicken embryos and human embryonic cells. This study reported that thalidomide causes limb defects by stabilizing PTEN, inhibiting the expression of Akt and activating caspase-dependent apoptosis. Thalidomide has also been used for studying glutathione mediated teratogenic resistance in mouse embryos.

Definition

ChEBI: A 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione that has R-configuration at the chiral centre.

reaction suitability

reagent type: ligand

Biochem/physiol Actions

(-)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α). (R)-Thalidomide is called "safe enantiomer", but it can be converted in the body to (S)-isomer.

(R)-(+)-THALIDOMIDE synthesis

Synthesis of (R)-(+)-THALIDOMIDE from D-Ornithine monohydrochloride

(R)-(+)-THALIDOMIDE Preparation Products And Raw materials

Raw materials

Pentanedioic acid, 2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, 1,5-dimethyl ester, (2S)- (-)-THALIDOMIDE Thalidomide N-Phthaloyl-L-glutamic acid N-Carbethoxyphthalimide

D-Ornithine monohydrochloride L-Glutamic acid Phthalic anhydride

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Preparation Products

(R)-(+)-THALIDOMIDE Suppliers

Global( 54)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Daicel Chiral Technologies (China)CO.,LTD	021-50460086-9 15921403865	han_yajun@dctc.daicel.com	China	7909	65
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 13167063860	anhua.mao@aladdin-e.com	China	29985	65
Clearsynth Labs Limited	+91-22-26355700	info@clearsynth.com	India	9656	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51389	80
Shanghai Chiral bio-compound co., Ltd.	021-5068 3667/17749785980/1029026415; 17749785980	1029026415@qq.com	China	4501	58
BOC Sciences	16314854226	info@bocsci.com	United States	9909	65
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9799	58

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chemsky（shanghai）International Co.,Ltd.	50
Daicel Chiral Technologies (China)CO.,LTD	65
Shanghai Aladdin Bio-Chem Technology Co.,LTD	65
Clearsynth Labs Limited	58
Sigma-Aldrich	80
Shanghai Chiral bio-compound co., Ltd.	58
BOC Sciences	65
Shanghai EFE Biological Technology Co., Ltd.	58

View Lastest Price from (R)-(+)-THALIDOMIDE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-27	(R)-Thalidomide 2614-06-4	$64.00-228.00		99.87%	10g	TargetMol Chemicals Inc.

(R)-Thalidomide
2614-06-4
$64.00-228.00
99.87%
TargetMol Chemicals Inc.

(R)-(+)-THALIDOMIDE Spectrum

(R)-(+)-THALIDOMIDE(2614-06-4)¹HNMR

2614-06-4((R)-(+)-THALIDOMIDE)Related Search:

3-Aminopiperidine Thalidomide (-)-THALIDOMIDE >98% INHIBITOR OF ANGIOG EN,(S)-(-)-THALIDOMIDE (R)-3-AMINOPIPERIDIN-2-ONE 3-amino-2-Piperidinone

(R)-(+)-THALIDOMIDE (R)-3-Aminopiperidine 3-(N-Acetyl-N-methylamino)piperidine 3-Acetamidopiperidine Phthalimidine, 2-(2,6-dioxopiperiden-3-yl).

N-(piperidin-3-yl)benzamide 3-DIMETHYLAMINOPIPERIDINE N-(2-AMINO-ETHYL)-PHTHALIMIDE THALIDOMIDE-D4 5'-HYDROXY THALIDOMIDE

Thalidomide (+ and -) 2-(2-(3-azido-4-iodophenylpropionamido)ethoxy)thalidomide THALIDOMIDE UN2811-III

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(R)-2-(2,6-DIOXO-3-PIPERIDINYL)-1H-ISOINDOLE-1,3-(2H)-DIONE R-(+)-2-(2,6-DIOXO-3-PIPERIDINYL)-1H-ISOINDOLE-1,3(2H)-DIONE (R)-(+)-THALIDOMIDE 6-dioxo-3-piperidinyl)-3(2h)-dion(r)-1h-isoindole-2-(2 6-dioxo-3-piperidyl)-n-(d-(+)-phthalimid (+)-2-[(R)-2,6-Dioxo-3-piperidinyl]-1H-isoindole-1,3(2H)-dione (+)-N-[(R)-2,6-Dioxo-3-piperidinyl]phthalimide (3R)-3-(1,3-Dioxo-2H-isoindole-2-yl)piperidine-2,6-dione N-[(R)-2,6-Dioxopiperidine-3-yl]phthalimide NSC 91729 2-[(3R)-2,6-dioxopiperidin-3-yl]isoindole-1,3-dione Thalidomide (R)-Isomer 1H-Isoindole-1,3(2H)-dione, 2-[(3R)-2,6-dioxo-3-piperidinyl]- (+)-Thalidomide 2614-06-4 6/4/2614 2614-6-4 Angiogenesis Regulators BioChemical Cell Signaling and Neuroscience Cell Biology Extracellular Matrix Cytoskeleton and Extracellular Matrix Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals