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ChemicalBook CAS DataBase List (R)-(+)-THALIDOMIDE
2614-06-4

(R)-(+)-THALIDOMIDE synthesis

8synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: SOCl2 / -15 - 20 °C
2: 606 mg / Et3N / acetonitrile / 4 h / 20 °C
3: 68 percent / Et3N / dimethylsulfoxide / 12 h / 4 - 20 °C
4: 55 percent / aq. NaIO4 / RuO2 / ethyl acetate; CH2Cl2 / 40 °C

References:

Suzuki, Emiko;Shibata, Norio [Enantiomer,2001,vol. 6,# 5,p. 275 - 279]

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