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1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-4-pyrazole boronic acid pinacol ester

1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-4-pyrazole boronic acid pinacol ester structure

CAS No.: 1040377-08-9

Chemical Name:: 1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-4-pyrazole boronic acid pinacol ester

Synonyms: 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethan-1-ol;2-(4-(4,4,5,5-TetramethyL;2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl);1-(hydroxyethyl)pyrazole-4-boronic acid pinacol ester;1-(2-Hydroxyethyl)-1H-pyrazole-4-boronic acid, pinacol ester;pyran-2-yloxy)ethyl)-1H-4-pyrazole boronic acid pinacol ester;(1-(2-HYDROXYETHYL)-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER;2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-...;1-(2-Hydroxyethyl)-1H-pyrazole-4-boronic acid, pinacol ester 95%;2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethan-1-ol

CBNumber:: CB92558559

Molecular Formula:: C11H19BN2O3

Molecular Weight:: 238.09

MDL Number:: MFCD12033564

MOL File:: 1040377-08-9.mol

MSDS File:: SDS

Last updated:2026-05-28 05:50:39

Product description	Number	Pack Size	Price
1-(2-Hydroxyethyl)-1H-pyrazole-4-boronic acid, pinacol ester 97%	OR51738	100mg	$21
1-(2-Hydroxyethyl)-1H-pyrazole-4-boronic acid, pinacol ester 97%	OR51738	250mg	$24
1-(2-Hydroxyethyl)-1H-pyrazole-4-boronic acid, pinacol ester 97%	OR51738	1g	$29
1-(2-Hydroxyethyl)-1H-pyrazole-4-boronic acid, pinacol ester 97%	OR51738	5g	$101
1-(2-Hydroxyethyl)-1H-pyrazole-4-boronic acid, pinacol ester 97%	OR51738	10g	$185
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1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-4-pyrazole boronic acid pinacol ester Properties

Boiling point	379.4±22.0 °C(Predicted)
Density	1.13±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
pka	14.47±0.10(Predicted)
form	solid
color	Off white
InChI	InChI=1S/C11H19BN2O3/c1-10(2)11(3,4)17-12(16-10)9-7-13-14(8-9)5-6-15/h7-8,15H,5-6H2,1-4H3
InChIKey	QEHDAUWYRNEWBF-UHFFFAOYSA-N
SMILES	N1(CCO)C=C(B2OC(C)(C)C(C)(C)O2)C=N1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P271-P261-P280
HS Code	2933199090

1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-4-pyrazole boronic acid pinacol ester price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	OR51738	1-(2-Hydroxyethyl)-1H-pyrazole-4-boronic acid, pinacol ester 97%	1040377-08-9	100mg	$21	2026-06-04	Buy
Apolloscientific	OR51738	1-(2-Hydroxyethyl)-1H-pyrazole-4-boronic acid, pinacol ester 97%	1040377-08-9	250mg	$24	2026-06-04	Buy
Apolloscientific	OR51738	1-(2-Hydroxyethyl)-1H-pyrazole-4-boronic acid, pinacol ester 97%	1040377-08-9	1g	$29	2026-06-04	Buy
Apolloscientific	OR51738	1-(2-Hydroxyethyl)-1H-pyrazole-4-boronic acid, pinacol ester 97%	1040377-08-9	5g	$101	2026-06-04	Buy
Apolloscientific	OR51738	1-(2-Hydroxyethyl)-1H-pyrazole-4-boronic acid, pinacol ester 97%	1040377-08-9	10g	$185	2026-06-04	Buy

Product number	Packaging	Price	Buy
OR51738	100mg	$21	Buy
OR51738	250mg	$24	Buy
OR51738	1g	$29	Buy
OR51738	5g	$101	Buy
OR51738	10g	$185	Buy

1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-4-pyrazole boronic acid pinacol ester Chemical Properties,Uses,Production

Uses

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-ethanol, can be used in the synthesis of series of aminopyridines with substituted benzoxazoles, acting c-Met kinase inhibitors.

Synthesis

96-49-1

269410-08-4

1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-4-pyrazole boronic acid pinacol ester

1040377-08-9

Vinyl carbonate (2.496 g, 28.3 mmol) and pinacol ester of 4-pyrazoleboronic acid (5 g, 25.8 mmol) were added with sodium hydroxide (0.103 g, 2.58 mmol) and N,N-dimethylformamide (DMF, 18 mL). The reaction mixture was stirred at 140°C for 16 h. Subsequently, it was cooled to room temperature and activated carbon (200 mg) was added. The mixture was continued to be stirred at room temperature for 1 h, followed by filtration. The insoluble material was washed with ethyl acetate (EtOAc, 50 mL) and ethanol (EtOH, 50 mL). The filtrate and washings were combined and concentrated under reduced pressure. The residue was initially purified by silica gel column chromatography (silica gel 50 g, elution gradient: 0 to 40% methanol/dichloromethane). Further purification by SP4 system using silica gel column (100 g, elution gradient: 0 to 20% methanol in dichloromethane solution) afforded the target product 1-(hydroxyethyl)pyrazole-4-boronic acid pinacol ester (5.58 g, 23.44 mmol, 91% yield) as a colorless oil, which was used directly in the subsequent reaction.LCMS (Method A): retention time 0.68 min, [ M + H]+ = 239.13.

References

[1] Patent: WO2011/54841, 2011, A1. Location in patent: Page/Page column 107
[2] Patent: WO2008/44022, 2008, A1. Location in patent: Page/Page column 35
[3] Patent: EP3112351, 2017, A1. Location in patent: Paragraph 0041
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 9, p. 3208 - 3212
[5] Patent: WO2010/19899, 2010, A1. Location in patent: Page/Page column 155

1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-4-pyrazole boronic acid pinacol ester Preparation Products And Raw materials

Raw materials

Ethylene carbonate 4-Pyrazoleboronic acid pinacol ester 2-Bromoethanol N,N-Dimethylformamide Sodium hydroxide

Preparation Products

1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-4-pyrazole boronic acid pinacol ester Suppliers

Global( 128)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-15225627621 +86-13213167925	jiuyitime@fdachem.com	China	16505	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
career henan chemical co	+86-0371-86658258	factory@coreychem.com	China	29780	58
CD Chemical Group Limited	+86-13651442114	info@codchem.com	China	17253	58
Henan Aochuang Chemical Co.,Ltd.	+86-0371-63689365 +8618638391208	sales@aochuangchem.com	China	9322	58
Henan Allgreen Chemical Co.,LTD	+86-37155567971 +86-13633837469	info@allgreenchem.com	China	5990	58
Suzhou Chukai Pharma Tech Co.,Ltd	+86-15151706780; +86-15062531973	2279973922@qq.com	China	404	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501	product@acmec-e.com	China	33301	58
Aladdin Scientific		tp@aladdinsci.com	United States	50108	58

Supplier	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Capot Chemical Co.,Ltd.	60
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
CD Chemical Group Limited	58
Henan Aochuang Chemical Co.,Ltd.	58
Henan Allgreen Chemical Co.,LTD	58
Suzhou Chukai Pharma Tech Co.,Ltd	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58

View Lastest Price from 1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-4-pyrazole boronic acid pinacol ester manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	2-(4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOL-1-YL)ETHANOL 1040377-08-9	$3.00-9.00		99%		ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2025-04-04	1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-4-pyrazole boronic acid pinacol ester 1040377-08-9		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2019-12-24	1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-4-pyrazole boronic acid pinacol ester 1040377-08-9	$1.00	100g	98%min		Career Henan Chemical Co

2-(4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOL-1-YL)ETHANOL
1040377-08-9
$3.00-9.00
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-4-pyrazole boronic acid pinacol ester
1040377-08-9
98%
Henan Aochuang Chemical Co.,Ltd.

1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-4-pyrazole boronic acid pinacol ester
1040377-08-9
$1.00
98%min
Career Henan Chemical Co

1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-4-pyrazole boronic acid pinacol ester Spectrum

1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-4-pyrazole boronic acid pinacol ester(1040377-08-9)¹HNMR

1040377-08-9(1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-4-pyrazole boronic acid pinacol ester)Related Search:

1-(2-Methoxyethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1-(ETHOXYCARBONYLMETHYL)-1H-PYRAZOLE-4-BORONIC ACID, PINACOL ESTER 4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-acetic acid methyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate B-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]boronic acid

1-{2-[(Tetrahydro-2H-pyran-2-yl)oxy]ethyl}-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1of2

1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-4-pyrazole boronic acid pinacol ester 1-(2-Hydroxyethyl)-1H-pyrazole-4-boronic acid, pinacol ester 2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethan-1-ol, 1-Hydroxy-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethane 2-(4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethanol 2-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)pyrazol-1-yl]ethanol 2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl) 1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-4-pyrazole boronic acid picol ester (1-(2-HYDROXYETHYL)-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER 2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethan-1-ol, 1-Hydroxy-2-[4-(4,4,5,5-tetrameth 4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-ethanol 2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethan-1-ol 1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-4-pyrazole boronic acid pinacol este 1-(hydroxyethyl)pyrazole-4-boronic acid pinacol ester 1-(2-Hydroxyethyl)-1H-pyrazole-4-boronic acid, pinacol ester 95% pyran-2-yloxy)ethyl)-1H-4-pyrazole boronic acid pinacol ester 2-(4-(4,4,5,5-TetramethyL 1H-Pyrazole-1-ethanol, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethan 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-... 1-(2-Hydroxyethyl)-1H-pyrazole-4-boronic acid pinacol ester - [H11815] 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethan-1-ol 1040377-08-9