ChemicalBook >> CAS DataBase List >>(1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile

(1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile

(1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile structure

CAS No.: 848344-36-5

Chemical Name:: (1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile

Synonyms: CS-401;AS 602801;Bentamapimod;AS 602801 (BentaMapiMod);Bentamapimod (AS 602801);AS-602801;BENTAMAPIMOD;AS602801;AS-602801,inhibit,JNK,Inhibitor,Bentamapimod,AS602801;2-Benzothiazoleacetonitrile, α-[2-[[4-(4-morpholinylmethyl)phenyl]methoxy]-4-pyrimidinyl]-;2-(Benzo[d]thiazol-2-yl)-2-(2-((4-(morpholinomethyl)benzyl)oxy)pyrimidin-4-yl)acetonitrile;(1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile

CBNumber:: CB92589641

Molecular Formula:: C25H23N5O2S

Molecular Weight:: 457.55

MDL Number:: MFCD08272350

MOL File:: 848344-36-5.mol

MSDS File:: SDS

Last updated:2026-01-20 19:14:41

Product description	Number	Pack Size	Price
AS602801 ≥98% (HPLC)	SML3358	5MG	$79.32
AS602801 ≥98% (HPLC)	SML3358	25MG	$320.15
Bentamapimod ≥98%	21482	1mg	$40
Bentamapimod ≥98%	21482	5mg	$177
Bentamapimod ≥98%	21482	10mg	$254
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(1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile Properties

Boiling point	666.5±65.0 °C(Predicted)
Density	1.326
storage temp.	2-8°C
solubility	insoluble in H2O; insoluble in EtOH; ≥11.45 mg/mL in DMSO
pka	6.47±0.10(Predicted)
form	solid
color	Light yellow to yellow
InChI	1S/C25H23N5O2S/c26-15-20(24-28-22-3-1-2-4-23(22)33-24)21-9-10-27-25(29-21)32-17-19-7-5-18(6-8-19)16-30-11-13-31-14-12-30/h1-10,20H,11-14,16-17H2
InChIKey	XCPPIJCBCWUBNT-UHFFFAOYSA-N
SMILES	[s]1c2c(nc1C(c3nc(ncc3)OCc4ccc(cc4)CN5CCOCC5)C#N)cccc2
FDA UNII	TT3L4B4U0N
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319-H335-H302+H312+H332-H315

Precautionary statements

P301+P312-P302+P352-P305+P351+P338

WGK Germany

WGK 3

HS Code

2934999090

Storage Class

11 - Combustible Solids

NFPA 704

	0
3		0

(1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML3358	AS602801 ≥98% (HPLC)	848344-36-5	5MG	$79.32	2025-07-31	Buy
Sigma-Aldrich	SML3358	AS602801 ≥98% (HPLC)	848344-36-5	25MG	$320.15	2025-07-31	Buy
Cayman Chemical	21482	Bentamapimod ≥98%	848344-36-5	1mg	$40	2024-03-01	Buy
Cayman Chemical	21482	Bentamapimod ≥98%	848344-36-5	5mg	$177	2024-03-01	Buy
Cayman Chemical	21482	Bentamapimod ≥98%	848344-36-5	10mg	$254	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML3358	5MG	$79.32	Buy
SML3358	25MG	$320.15	Buy
21482	1mg	$40	Buy
21482	5mg	$177	Buy
21482	10mg	$254	Buy

(1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile Chemical Properties,Uses,Production

Description

Bentamapimod is an orally bioavailable inhibitor of Jun kinases (JNKs), with IC₅₀ values for JNK1, JNK2, and JNK3 of 80, 90, and 230 nM, respectively. It is selective for JNKs over a panel of 25 related kinases. Bentamapimod induces regression of endometriotic lesions without suppressing estrogen action in animal models of endometriosis. It blocks proliferation and induces apoptosis of T cells in vitro and inhibits cancer stem cell survival, self-renewal, and tumor-initiating capacity in vitro and in mice.

Uses

Bentamapimod is a potent and selective JNK inhibitor with therapeutic potential in MS (multiple sclerosis) and fibrosis. Studies show that Bentamapimod also reduced induced endometriosis in baboons.

in vitro

as602801 blocked t-lymphocyte proliferation and induced apoptosis. in rrms cd4t and cd8t cells, as602801 induced apoptosis genes and expression of surface markers, while in rrms cd11bt cells it induced expression of innate immunity receptors and co-stimulatory molecules [1].

in vivo

as602801, the best jnk inhibitors identified so far, were currently evaluated in preclinical studies, based on preliminary promising results in animal model of auto-immune diseases and neuronal apoptosis [1].

IC 50

JNK1: 80 nM (IC₅₀); JNK2: 90 nM (IC₅₀); JNK3: 230 nM (IC₅₀)

References

[1] ferrandi c, richard f, tavano p, hauben e, barbié v, gotteland jp, greco b, fortunato m, mariani mf, furlan r, comi g, martino g, zaratin pf. characterization of immune cell subsets during the active phase of multiple sclerosis reveals disease and c-jun n-terminal kinase pathway biomarkers. mult scler. 2011;17(1):43-56.

(1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

(1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile Suppliers

Global( 108)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32470	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30229	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471;	sales@sarms4muscle.com	China	10473	58
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	17259	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
PT CHEM GROUP LIMITED	+86-85511178;	peter68@ptchemgroup.com	China	35425	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Zhejiang J&C Biological Technology Co.,Limited	58
CD Chemical Group Limited	58
InvivoChem	58
Nantong HI-FUTURE Biology Co., Ltd.	58
PT CHEM GROUP LIMITED	58

View Lastest Price from (1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-01-20	Bentamapimod 848344-36-5	US $38.00-101.00 / mg		99.51%	10g	TargetMol Chemicals Inc.

Bentamapimod
848344-36-5
US $38.00-101.00 / mg
99.51%
TargetMol Chemicals Inc.

(1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile Spectrum

(1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile(848344-36-5)MS (1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile(848344-36-5)¹HNMR

848344-36-5((1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile)Related Search:

H-TYR-LEU-OH

(1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile AS 602801 Bentamapimod AS 602801 (BentaMapiMod) (1,3-Benzothiazol-2-yl)[2-[[4-[(morpholin-4-yl)methyl]benzyl]oxy]pyrimidin-4-yl]acetonitrile AS602801(Bentamapimod) Bentamapimod (AS 602801) CS-401 2-(1,3-benzothiazol-2-yl)-2-[2-[[4-(morpholin-4-ylmethyl)phenyl]methoxy]pyrimidin-4-yl]acetonitrile AS-602801;BENTAMAPIMOD;AS602801 2-Benzothiazoleacetonitrile, α-[2-[[4-(4-morpholinylmethyl)phenyl]methoxy]-4-pyrimidinyl]- AS-602801,inhibit,JNK,Inhibitor,Bentamapimod,AS602801 2-(Benzo[d]thiazol-2-yl)-2-(2-((4-(morpholinomethyl)benzyl)oxy)pyrimidin-4-yl)acetonitrile 848344-36-5 Inhibitors