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ChemicalBook >> CAS DataBase List >>2-chloro-3-fluoropyridin-4-aMine

2-chloro-3-fluoropyridin-4-aMine

2-chloro-3-fluoropyridin-4-aMine Structure
2-chloro-3-fluoropyridin-4-aMine structure
CAS No.
1227577-03-8
Chemical Name:
2-chloro-3-fluoropyridin-4-aMine
Synonyms
2-chloro-3-fluoropyridin-4-aMine;2-Chloro-3-fluoro-4-pyridinamine;4-Amino-2-chloro-3-fluoropyridine;4-Pyridinamine, 2-chloro-3-fluoro-;2-Chloro-3-fluoro-pyridin-4-ylamine
CBNumber:
CB92598773
Molecular Formula:
C5H4ClFN2
Molecular Weight:
146.55
MDL Number:
MFCD16606117
MOL File:
1227577-03-8.mol
Last updated:2025-07-24 18:11:54
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2-chloro-3-fluoropyridin-4-aMine Properties

Boiling point 271.9±35.0 °C(Predicted)
Density 1.449±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 2.81±0.42(Predicted)
form powder
color Brown
InChI InChI=1S/C5H4ClFN2/c6-5-4(7)3(8)1-2-9-5/h1-2H,(H2,8,9)
InChIKey VUGYOFOYGPXOFL-UHFFFAOYSA-N
SMILES C1(Cl)=NC=CC(N)=C1F

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P260-P280-P301+P310
HS Code  2933399990

2-chloro-3-fluoropyridin-4-aMine price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC C369798 2-Chloro-3-fluoropyridin-4-amine 1227577-03-8 50mg $65 2021-12-16 Buy
TRC C369798 2-Chloro-3-fluoropyridin-4-amine 1227577-03-8 100mg $90 2021-12-16 Buy
ChemScene CS-W021639 2-Chloro-3-fluoropyridin-4-amine 99.90% 1227577-03-8 1g $93 2021-12-16 Buy
Apolloscientific PC400526 4-Amino-2-chloro-3-fluoropyridine 1227577-03-8 1g $93 2021-12-16 Buy
SynQuest Laboratories 3H30-7-0A 4-Amino-2-chloro-3-fluoropyridine 1227577-03-8 1g $103 2021-12-16 Buy
Product number Packaging Price Buy
C369798 50mg $65 Buy
C369798 100mg $90 Buy
CS-W021639 1g $93 Buy
PC400526 1g $93 Buy
3H30-7-0A 1g $103 Buy

2-chloro-3-fluoropyridin-4-aMine Chemical Properties,Uses,Production

Synthesis

TFA (5 mL) was added to a solution of (2- chloro-3-fluoropyridin-4-yl)carbamic acid fert-butyl ester (1.9 g, 7.7 mmol) in DCM (10 mL). The solution was stirred at ambient temperature for 5 hours and concentrated under reduced pressure. The resultant residue was dissolved in DCM and purified by column chromatography on an NH2 cartridge (0-10 per cent MeOH in DCM) to afford 2-chloro-3-fluoropyridin-4-aMine as a beige solid (0.96 g, 94 per cent yield). NMR (400 MHz, CDC13): δ 7.82 (d, J = 5.4 Hz, 1H), 6.60 (t, J= 5.8 Hz, 1H), 4.38 (br s, 2H).

References

[1] Patent: WO2012/35039, 2012, A1. Location in patent: Page/Page column 97
[2] Patent: US2015/203455, 2015, A1. Location in patent: Paragraph 0461; 0463
[3] Patent: WO2015/110378, 2015, A1. Location in patent: Paragraph 00263; 00312
[4] Patent: US9440929, 2016, B2. Location in patent: Page/Page column 59; 60
[5] Patent: WO2017/12647, 2017, A1. Location in patent: Paragraph 0502

2-chloro-3-fluoropyridin-4-aMine synthesis

1354223-71-4
1227577-03-8
Synthesis of 2-chloro-3-fluoropyridin-4-aMine from (2-Chloro-3-fluoro-pyridin-4-yl)-carbamic acid tert-butyl ester

2-chloro-3-fluoropyridin-4-aMine Preparation Products And Raw materials

Raw materials

(2-Chloro-3-fluoro-pyridin-4-yl)-carbamic acid tert-butyl ester 2-Chloro-3-fluoropyridine-4-carboxylic acid Trifluoroacetic acid Dichloromethane

Preparation Products

2-chloro-3-fluoropyridin-4-aMine Suppliers

Global( 136)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8617732866630 abby@chuanghaibio.com China 8773 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
NINGBOBENKANGJS PHARMTECHCO., LTD 		+8615990591583 15990591583 CHINA 2029 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 sales@sarms4muscle.com China 10473 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Aceschem Inc. 		+1-817863-6948 +1-（817）863-6948 sales@aceschem.com United States 19632 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
Accela ChemBio Inc. 		58
Alchem Pharmtech,Inc. 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
NINGBOBENKANGJS PHARMTECHCO., LTD 		58
Hefei Hirisun Pharmatech Co., Ltd 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Aceschem Inc. 		58

View Lastest Price from 2-chloro-3-fluoropyridin-4-aMine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-chloro-3-fluoropyridin-4-aMine pictures 2025-06-24 2-chloro-3-fluoropyridin-4-aMine
1227577-03-8
 US $10.00 / KG 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
2-Chloro-3-fluoropyridin-4-amine pictures 2024-04-23 2-Chloro-3-fluoropyridin-4-amine
1227577-03-8
 US $5.00 / kg 1kg 99.92% 50000tons Ouhuang Engineering Materials (Hubei) Co., Ltd

2-chloro-3-fluoropyridin-4-aMine Spectrum

2-chloro-3-fluoropyridin-4-aMine(1227577-03-8)1HNMR

1227577-03-8(2-chloro-3-fluoropyridin-4-aMine)Related Search:

4-broMo-2-chloro-3-fluoropyridine 2-CHLORO-3-FLUOROPYRIDINE-4-BORONIC ACID
4-Amino-2-chloro-3-fluoropyridine 2-Chloro-3-fluoro-pyridin-4-ylamine 2-chloro-3-fluoropyridin-4-aMine 4-Pyridinamine, 2-chloro-3-fluoro- 2-Chloro-3-fluoro-4-pyridinamine 1227577-03-8