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2-Chloro-3-fluoropyridine-4-carboxylic acid

2-Chloro-3-fluoropyridine-4-carboxylic acid structure

CAS No.: 628691-93-0

Chemical Name:: 2-Chloro-3-fluoropyridine-4-carboxylic acid

Synonyms: 2-CHLORO-3-FLUOROISONICOTINIC ACID;2-Chloro-3-FluoroisonicotinicAci;2-CHLORO-3-FLUOROPYRIDINE-4-CARBOXYLIC ACID;2-chloro-3-fluoro-4-pyridinecarboxylic acid;2-Chloro-3-Fluoroisonicotinic Acid(WX614144);4-Pyridinecarboxylic acid, 2-chloro-3-fluoro-;2-CHLORO-3-FLUOROISONICOTINIC ACID ISO 9001：2015 REACH;2-Chloro-3-fluoropyridine-4-carboxylic acid, 4-Carboxy-2-chloro-3-fluoropyridine

CBNumber:: CB5276031

Molecular Formula:: C6H3ClFNO2

Molecular Weight:: 175.54

MDL Number:: MFCD04038325

MOL File:: 628691-93-0.mol

MSDS File:: SDS

Last updated:2026-05-28 02:10:49

Product description	Number	Pack Size	Price
2-Chloro-3-fluoroisonicotinic acid ≥95%	PC8963	1g	$21
2-Chloro-3-fluoroisonicotinic acid 95%	J53304	1g	$12
2-Chloro-3-fluoroisonicotinic acid 95%	J53304	5g	$17
2-Chloro-3-fluoroisonicotinic acid 95%	J53304	25g	$56
2-Chloro-3-fluoroisonicotinic acid 95%	J53304	100g	$175
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2-Chloro-3-fluoropyridine-4-carboxylic acid Properties

Melting point	199 °C (dec.)
Boiling point	389.1±37.0 °C(Predicted)
Density	1.576±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	2.07±0.10(Predicted)
form	powder
color	Off-white
InChI	InChI=1S/C6H3ClFNO2/c7-5-4(8)3(6(10)11)1-2-9-5/h1-2H,(H,10,11)
InChIKey	NWNWBLRKHOVSEL-UHFFFAOYSA-N
SMILES	C1(Cl)=NC=CC(C(O)=O)=C1F
CAS DataBase Reference	628691-93-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P280g-P261-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

HazardClass

IRRITANT

HS Code

2933399990

NFPA 704

	0
2		0

2-Chloro-3-fluoropyridine-4-carboxylic acid price More Price(61)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	PC8963	2-Chloro-3-fluoroisonicotinic acid ≥95%	628691-93-0	1g	$21	2026-06-04	Buy
AK Scientific	J53304	2-Chloro-3-fluoroisonicotinic acid 95%	628691-93-0	1g	$12	2026-06-04	Buy
AK Scientific	J53304	2-Chloro-3-fluoroisonicotinic acid 95%	628691-93-0	5g	$17	2026-06-04	Buy
AK Scientific	J53304	2-Chloro-3-fluoroisonicotinic acid 95%	628691-93-0	25g	$56	2026-06-04	Buy
AK Scientific	J53304	2-Chloro-3-fluoroisonicotinic acid 95%	628691-93-0	100g	$175	2026-06-04	Buy

Product number	Packaging	Price	Buy
PC8963	1g	$21	Buy
J53304	1g	$12	Buy
J53304	5g	$17	Buy
J53304	25g	$56	Buy
J53304	100g	$175	Buy

2-Chloro-3-fluoropyridine-4-carboxylic acid Chemical Properties,Uses,Production

Uses

2-Chloro-3-fluoropyridine-4-carboxylic acid is a carboxylic acid, which has been reported in the literature to be used in the preparation of antiplatelet drugs of the ADP receptor antagonist class.

Synthesis

17282-04-1

124-38-9

2-Chloro-3-fluoropyridine-4-carboxylic acid

628691-93-0

1. In a dry reaction flask, lithium diisopropylamide (2M in heptane/tetrahydrofuran/ethylbenzene, 16.7 ml) was mixed with tetrahydrofuran (30 ml) and cooled to -78 °C. 2. A solution of 2-chloro-3-fluoropyridine (4.0 g, 30.4 mmol) in tetrahydrofuran (30 ml) pre-cooled to -78°C was added dropwise to the above cooled mixture over a period of 20 min. 3. After 3 hours of reaction, carbon dioxide was bubbled into the cold reaction mixture for 20 minutes. 4. The reaction mixture was gradually heated to -30 °C for 1 h and then continued to 0 °C. The reaction mixture was heated to -30 °C for 1 h and then continued to 0 °C. 5. The reaction was quenched by addition of water (75 ml) and the aqueous phase was washed with ether (100 ml). 6. The pH of the aqueous phase was adjusted to 2 with 2N hydrochloric acid to produce a white precipitate, which was aged for 18 h. The mixture was filtered and air-dried to give 2-chloro-3-fluoroisonicotinic acid (4.22 g, 79%). 7. 2-Chloro-3-fluoroisonicotinic acid (3.30 g, 18.8 mmol) was suspended in thionyl chloride (40 ml) and heated to reflux for 2.5 hours. 8. The solvent was evaporated and the residue was azeotropically dried with toluene (100 ml) to give a light yellow oil. 9. The oily substance was dissolved in dichloromethane (20 ml), cooled to 0 °C and methanol (2.42 g, 75.3 mmol) was added dropwise over 15 min. 10. After the dropwise addition, the mixture was warmed to room temperature and stirred for 18 hours. 11. The solvent was evaporated and the mixture was partitioned between water (75 ml) and dichloromethane (100 ml). 12. The aqueous phase was further extracted with dichloromethane (100 ml), the organic layers were combined, washed with brine (75 ml), dried over anhydrous sodium sulfate, filtered and evaporated to give methyl 2-chloro-3-fluoroisonicotinate (3.32 g, 93%). 13. 2-Chloro-3-fluoroisonicotinic acid methyl ester (3.32 g, 17.5 mmol) was converted to 8-fluoroimidazo[1,2-a]pyridine-7-carboxylic acid methyl ester (1.4 g, 41%). 14. 8-Fluoroimidazo[1,2-a]pyridine-7-carboxylic acid methyl ester (0.19 g, 1.0 mmol) was brominated to give methyl 3-bromo-8-fluoroimidazo[1,2-a]pyridine-7-carboxylate (195 mg, 71%). 15. 3-Bromo-8-fluoroimidazo[1,2-a]pyridine-7-carboxylic acid methyl ester (0.10 g, 0.37 mmol) was coupled with 4,2'-difluoro-5'-(5,5-dimethyl[1,3,2]dioxaborolan-2-yl)biphenyl-2-ylcarbonitrile (0.15 g, 0.44 mmol) to give 3-(2'-cyano-2,4'-difluoro-biphenyl- 5-yl)-8-fluoroimidazo[1,2-a]pyridine-7-carboxylic acid methyl ester (79 mg, 53%).

References

[1] Patent: WO2003/99816, 2003, A1. Location in patent: Page 61
[2] Patent: WO2011/37771, 2011, A1. Location in patent: Page/Page column 24-25

2-Chloro-3-fluoropyridine-4-carboxylic acid synthesis

Synthesis of 2-Chloro-3-fluoropyridine-4-carboxylic acid from 2-Chloro-3-fluoropyridine and Carbon dioxide

2-Chloro-3-fluoropyridine-4-carboxylic acid Preparation Products And Raw materials

Raw materials

Nitrogen Hexachloroethane Carbon dioxide 3-Fluoropyridine Tetrahydrofuran

Triethylenediamine Petroleum ether n-Butyllithium 2-Chloro-3-fluoropyridine Hydrochloric acid

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Preparation Products

2-chloro-3-fluoropyridin-4-aMine

2-Chloro-3-fluoropyridine-4-carboxylic acid Suppliers

Global( 221)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10399	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8491	58
Accela ChemBio Inc.	+1-858-6993322 +86-18019713315	info@accelachem.com	United States	21189	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63645	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10817	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
Jinan Liheng Biotechnology Co., Ltd.	15865262812	info@lihengpharm.com	CHINA	937	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9631	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Jinan Liheng Biotechnology Co., Ltd.	58
Antai Fine Chemical Technology Co.,Limited	58

View Lastest Price from 2-Chloro-3-fluoropyridine-4-carboxylic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-18	2-CHLORO-3-FLUOROISONICOTINIC ACID 628691-93-0	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2025-04-04	2-CHLORO-3-FLUOROISONICOTINIC ACID 628691-93-0		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2019-07-06	2-CHLORO-3-FLUOROISONICOTINIC ACID 628691-93-0	$1.00	1kg	99%		Career Henan Chemical Co

2-CHLORO-3-FLUOROISONICOTINIC ACID
628691-93-0
$1.10
99.00%
Dideu Industries Group Limited

2-CHLORO-3-FLUOROISONICOTINIC ACID
628691-93-0
98%
Henan Aochuang Chemical Co.,Ltd.

2-CHLORO-3-FLUOROISONICOTINIC ACID
628691-93-0
$1.00
99%
Career Henan Chemical Co

2-Chloro-3-fluoropyridine-4-carboxylic acid Spectrum

2-Chloro-3-fluoropyridine-4-carboxylic acid(628691-93-0)¹HNMR

628691-93-0(2-Chloro-3-fluoropyridine-4-carboxylic acid)Related Search:

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2-CHLORO-3-FLUOROPYRIDINE-4-CARBOXYLIC ACID 2-Chloro-3-fluoropyridine-4-carboxylic acid, 4-Carboxy-2-chloro-3-fluoropyridine 2-Chloro-3-Fluoroisonicotinic Acid(WX614144) 2-chloro-3-fluoro-4-pyridinecarboxylic acid 4-Pyridinecarboxylic acid, 2-chloro-3-fluoro- 2-Chloro-3-FluoroisonicotinicAci 2-CHLORO-3-FLUOROISONICOTINIC ACID ISO 9001：2015 REACH 2-CHLORO-3-FLUOROISONICOTINIC ACID 628691-93-0 Building Blocks C5 to C6 C6 to C7 Chemical Synthesis Fluorinated Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Heterocyclic Fluorinated Building Blocks Other Fluorinated Heterocycles Pyridines Boronic Acid