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Voriconazole-d3

Voriconazole-d3 structure

CAS No.: 188416-29-7

Chemical Name:: Voriconazole-d3

Synonyms: 3R)-2-(2;VORICONAZOLE-D3;(±)-Voriconazole;Voriconazole PI-6;(2R,3R)-Voriconazole;Fluconazole Intermediate 2;Voriconazole Intermediate II;Intermediate 2 of voriconazole;4-triazol-1-yl)-2-butanol (RaceMic Voriconazole);4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1

CBNumber:: CB92610550

Molecular Formula:: C16H14F3N5O

Molecular Weight:: 349.31

MDL Number:: MFCD09263753

MOL File:: 188416-29-7.mol

MSDS File:: SDS

Last updated:2026-05-28 06:05:47

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Voriconazole-d3 Properties

Boiling point	508.6±60.0 °C(Predicted)
Density	1.42±0.1 g/cm3(Predicted)
storage temp.	Storage temp. 2-8°C
pka	11.54±0.29(Predicted)
form	Solid
color	White to off-white
InChI	InChI=1/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/s3
InChIKey	BCEHBSKCWLPMDN-NLBNCHMPNA-N
SMILES	C[C@@H]([C@@](CN1C=NC=N1)(C1C(F)=CC(F)=CC=1)O)C1C(F)=CN=CN=1 \|&1:1,2,r\|
FDA UNII	USG4B1CD29

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Voriconazole-d3 price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	17803	Voriconazole-d3 ≥99% deuterated forms (d₁-d₃)		500 μg	$175	2023-06-20	Buy
Cayman Chemical	17803	Voriconazole-d3 ≥99% deuterated forms (d₁-d₃)		1 mg	$306	2023-06-20	Buy
Biosynth	NHA41629	(±)-Voriconazole	188416-29-7	5000mg	$1350	2026-06-04	Buy
Biosynth	NHA41629	(±)-Voriconazole	188416-29-7	10000mg	$1800	2026-06-04	Buy
ChemScene	CS-0448910	(±)-Voriconazole 99.06%	188416-29-7	5mg	$27	2026-06-04	Buy

Product number	Packaging	Price	Buy
17803	500 μg	$175	Buy
17803	1 mg	$306	Buy
NHA41629	5000mg	$1350	Buy
NHA41629	10000mg	$1800	Buy
CS-0448910	5mg	$27	Buy

Voriconazole-d3 Chemical Properties, Uses, Production

Description

Voriconazole-d3 is an Ergosterol biosynthesis inhibitor and a labeled form of Voriconazole. This mono triazole antifungal agent inhibits the growth of Candida, Cryptococcus, and Aspergillus species. Studies suggest that Voriconazole-d3 can be synthesized by modifying the structure of fluconazole. This antifungal agent functions by inhibiting cytochrome P450 dependent 14-α-sterol demethylase, which is responsible for the biosynthesis of Ergosterol. Furthermore, Voriconazole-d3 inhibits fungal growth, cell wall thinning, and cell membrane degradation.

Uses

Voriconazole is a triazole antifungal agent used primarily in the treatment or prevention of aspergillosis and candidal infections. However, its therapy may cause transient, asymptomatic serum aminotransferase elevations, and it is also a well-known cause of acute drug-induced liver injury.

Application

Voriconazole-d3 is derived from 2,4-Difluoro-α-(1H-1,2,4-triazolyl)acetophenone, which is an antifungal activity, particularly toward Candida albicans and Candida parapsilosis.

References

1. Voriconazole (UK-109,496) inhibits the growth and alters the morphology of fluconazole-susceptible and -resistant Candida species DOI:10.1128/AAC.41.8.1840
Belanger, P., et al. 1997. Antimicrob. Agents Chemother. 41: 1840-1842. PMID: 9257776
2. In vitro activities of voriconazole (UK-109,496) and four other antifungal agents against 394 clinical isolates of Candida spp
Marco, F., et al. 1998. Antimicrob. Agents Chemother. 42: 161-163. PMID: 9449278
3. In vitro activity of the new triazole voriconazole (UK-109,496) against opportunistic filamentous and dimorphic fungi and common and emerging yeast pathogens
Espinel-Ingroff, A. 1998. J. Clin. Microbiol. 36: 198-202. PMID: 9431946

Voriconazole-d3 Preparation Products And Raw materials

Raw materials

Preparation Products

Voriconazole-d3 Suppliers

Global Suppliers ( 78)

Supplier	Tel	Email	Country	ProdList	Advantage
Beijing Lianben Pharm-Chemicals Tech. Co., Ltd	+86-10-83386766	sales@lianben.com	China	91	58
Hubei XinyuanShun Chemical Co., Ltd.	13971561712, 13995564702, 027-50664929	hbeixys2001@163.com	China	3110	55
HuBei ShengBaoLai Biological Technology Co., Ltd	027-59105235 13007105135	sbl1120@163.com	China	96	55
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
ChongQing Purel Bio-Pharmaceutical Technology Co., Ltd.	023-89130144 18523560356	zhyong1011@163.com	China	297	58
NINGBO INNO PHARMCHEM CO.,LTD.	86-574-27787657	info@dearchem.com	China	4607	58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	025-66028182 17714375163	yftan@aikonchem.com	China	16674	50
Shanghai Synchem Pharma Co., ltd	21-619849051-1 18521059765	synchempharma@aliyun.com	China	4988	55
Roark Standards	0755-83552066 15986688328	service@roarkstandards.com	China	1442	58
Zhengzhou Acme Chemical Co., Ltd.	0371-0371-55629727 13323845623	2885676761@qq.com	China	9957	58

Supplier	Advantage
Beijing Lianben Pharm-Chemicals Tech. Co., Ltd	58
Hubei XinyuanShun Chemical Co., Ltd.	55
HuBei ShengBaoLai Biological Technology Co., Ltd	55
Bide Pharmatech Ltd.	60
ChongQing Purel Bio-Pharmaceutical Technology Co., Ltd.	58
NINGBO INNO PHARMCHEM CO.,LTD.	58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	50
Shanghai Synchem Pharma Co., ltd	55
Roark Standards	58
Zhengzhou Acme Chemical Co., Ltd.	58

View Latest Price from Voriconazole-d3 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2022-09-15	Voriconazole Intermediate II 188416-29-7	$28.00-30.00	1Kg	99.0% up	50 tons per month	Xinxiang Hongqi District Houyuan Trading Co.,Ltd
	2019-07-06	(2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (RaceMic Voriconazole) 188416-29-7	$7.00	1KG	99%	100kg	Career Henan Chemical Co

Voriconazole Intermediate II
188416-29-7
$28.00-30.00
99.0% up
Xinxiang Hongqi District Houyuan Trading Co.,Ltd

(2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (RaceMic Voriconazole)
188416-29-7
$7.00
99%
Career Henan Chemical Co

Voriconazole-d3 Spectrum

Voriconazole-d3(188416-29-7)¹HNMR

188416-29-7 (Voriconazole-d3) Related Search:

4-Ethyl-5-fluoropyrimidine Voriconazole Impurity 16 Ethanone, 1-(3,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)- 1-Butanesulfonic acid, 4-hydroxy-, methyl ester Pyrimidine, 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis[2,6-dichloro-5-fluoro- (9CI)

Pyrimidine, 4-bromo-6-(1-bromoethyl)-5-fluoro- 1,2,4-Triazole Voriconazole Impurity 53 Voriconazole (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

ent-Voriconazole (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride 4-Ethyl-5-fluoro-6-hydroxypyrimidine 6-(1-Bromoethyl)-4-chloro-5-fluoropyrimidine 2-Chloro-2',4'-difluoroacetophenone

Fenofibric acid ethyl ester 1-(5-(2-fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine Vonoprazan-d4 Fumarate

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(2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (RaceMic Voriconazole) (2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (2S,3R)-rel-2-(2,4-Difluorophenyl)-3-(5-fluoropyriMidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol Voriconazole PI-6 (2R,3R)-Voriconazole (R *, S *) 3- (5-fluoropyrimidin-4-yl) -2- (2,4-difluorophenyl) -1- (1H-1,2,4-triazol-1-yl ) -2-butanol (2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol 3R)-2-(2 4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1 4-triazol-1-yl)-2-butanol (RaceMic Voriconazole) (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyriMidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (RaceMic Voriconazole)ChemicalBook 4-Pyrimidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βS)-rel- (2R, 3S/2S, 3R)-3-(5-Fluoropyrimidin-4-yl)-2-(2,4-difluorophyenyl)-1-(1H-1,2,4 triazol-1-yl) butan-2-ol {Racemic Voriconazole} VORICONAZOLE-D3 Voriconazole Intermediate II Intermediate 2 of voriconazole Fluconazole Intermediate 2 (2RS,3SR)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (±)-Voriconazole 188416-29-7