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2-Chloro-2',4'-difluoroacetophenone

2-Chloro-2',4'-difluoroacetophenone structure

CAS No.: 51336-94-8

Chemical Name:: 2-Chloro-2',4'-difluoroacetophenone

Synonyms: 2-CHLORO-1-(2,4-DIFLUOROPHENYL)ETHANONE;2,4-difluorophenacyl chloride ,2-chloro-1-(2,4-difluorophenyl)ethanone;2-Chloro-2;Voriconazole RC1;TIMTEC-BB SBB006665;Voriconazole Impurity 6;2,4-DIFLUOROPHENACYL CHLORIDE;2,4-Difluorophenacylchloride98%;2,4-Difluorophenacyl chloride 98%;2'-Chloro 2,4-fluoro acetophenone

CBNumber:: CB3205231

Molecular Formula:: C8H5ClF2O

Molecular Weight:: 190.57

MDL Number:: MFCD00013252

MOL File:: 51336-94-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-06-04 16:00:12

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2-Chloro-2',4'-difluoroacetophenone Properties

Melting point	44-48 °C(lit.)
Boiling point	240.9±25.0 °C(Predicted)
Density	1.3544 (estimate)
Flash point	>230 °F
storage temp.	Inert atmosphere,2-8°C
solubility	Chloroform (Slightly)
form	Solid
color	Light Brown
Sensitive	Lachrymatory
BRN	1943217
InChI	InChI=1S/C8H5ClF2O/c9-4-8(12)6-2-1-5(10)3-7(6)11/h1-3H,4H2
InChIKey	UENGBOCGGKLVJJ-UHFFFAOYSA-N
SMILES	C(=O)(C1=CC=C(F)C=C1F)CCl
CAS DataBase Reference	51336-94-8(CAS DataBase Reference)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS06,GHS09

Signal word

Danger

Hazard statements

H301-H314-H317-H330-H410

Precautionary statements

P260-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338

PPE

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Hazard Codes

C,Xi

Risk Statements

34-37

Safety Statements

26-36/37/39-45-25-27

RIDADR

UN 3261 8/PG 2

WGK Germany

10-21

Hazard Note

Corrosive/Irritant/Lachrymatory

HazardClass

PackingGroup

HS Code

29147000

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials

Hazard Classifications

Acute Tox. 1 Inhalation
Acute Tox. 3 Oral
Aquatic Chronic 1
Eye Dam. 1
Skin Corr. 1B
Skin Sens. 1A

REACH Registrations

Inactive

Limited Quantities

1 Kg (2.2 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

NFPA 704

	1
3		0

2-Chloro-2',4'-difluoroacetophenone price More Price(55)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	272507	2-Chloro-2′,4′-difluoroacetophenone 98%	51336-94-8	5g	$130	2023-06-20	Buy
Sigma-Aldrich	272507	2-Chloro-2′,4′-difluoroacetophenone 98%	51336-94-8	25g	$135	2023-01-07	Buy
TCI Chemical	C2030	2-Chloro-2',4'-difluoroacetophenone >98.0%(GC)	51336-94-8	5g	$39	2026-04-30	Buy
TCI Chemical	C2030	2-Chloro-2',4'-difluoroacetophenone >98.0%(GC)	51336-94-8	25g	$116	2026-04-30	Buy
TRC	TRC-C365670-25G	2-Chloro-2',4'-difluoroacetophenone	51336-94-8	25g	$275	2026-06-03	Buy

Product number	Packaging	Price	Buy
272507	5g	$130	Buy
272507	25g	$135	Buy
C2030	5g	$39	Buy
C2030	25g	$116	Buy
TRC-C365670-25G	25g	$275	Buy

2-Chloro-2',4'-difluoroacetophenone Chemical Properties,Uses,Production

Description

2-Chloro-2′,4′-difluoroacetophenone was used in the synthesis of allyl alcohol1. It can also be tested for inhibition of protein tyrosine phosphatases SHP-1 and PTP1B2.

Chemical Properties

white crystalline powder

Uses

A α-haloacetophenone derivatives tested for inhibition of protein tyrosine phosphatases SHP-1 and PTP1B.

Uses

2-Chloro-2′,4′-difluoroacetophenone was used in the synthesis of allyl alcohol.

Synthesis

372-18-9

79-04-9

51336-94-8

In a 250 mL four-necked flask equipped with a thermometer, a constant pressure dropping funnel, and a reflux condenser (with a drying tube), 1,3-difluorobenzene (0.1 mol, 14.7 g) and anhydrous aluminum trichloride (0.17 mol, 22.7 g) were added. The mixture was stirred at 30-35°C for 0.5 hours. Subsequently, chloroacetyl chloride (0.12 mol, 13.56 g) was slowly added dropwise to maintain the reaction temperature. After the dropwise addition was completed, the temperature was raised to 50-55 °C and the reaction was continued with stirring until no hydrogen chloride gas escaped, a reaction time of about 5 hours. The reaction mixture was cooled to below 5°C in an ice-water bath, and acid hydrolysis was carried out by slowly dropping 3 mol/L hydrochloric acid (20 mL), controlling the rate of dropwise acceleration to keep the temperature of the mixture low. The acid-hydrolyzed mixture was poured into a beaker and distilled water was added to precipitate the solid. After filtration and drying under reduced pressure, 16.9 g of light yellow powdery solid was obtained in 89.3% yield. Finally, the light yellow powdery solid was recrystallized with hexane to give bright yellow crystalline 2'-chloro-2,4-difluoroacetophenone.

References

[1] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003, vol. 42, # 2, p. 372 - 381
[2] Tetrahedron Asymmetry, 2010, vol. 21, # 13-14, p. 1649 - 1665
[3] Patent: CN106187924, 2016, A. Location in patent: Paragraph 0026; 0027
[4] Patent: CN102796080, 2016, B. Location in patent: Paragraph 0040-0042
[5] Journal of Organic Chemistry, 1995, vol. 60, # 10, p. 3000 - 3012

2-Chloro-2',4'-difluoroacetophenone Preparation Products And Raw materials

Raw materials

1,3-Difluorobenzene 4-(2-Chloroacetyl)morpholine 1-Bromo-2,4-difluorobenzene Chloroacetyl chloride

Preparation Products

1,3-Propanediol, 2-[2-(2,4-difluorophenyl)-2-propen-1-yl]- Ravuconazole Benzenemethanol, α-(chloromethyl)-2,4-difluoro- (S)-3-(tert-butyl(2-(2,4-difluorophenyl)-2-hydroxyethyl)amino)propanenitrile

2-Chloro-2',4'-difluoroacetophenone Suppliers

Global( 382)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Fuxin Simai Chemical Technology Co., Ltd.	13841818553	929964679@qq.com	China	446	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2915	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Liaoning Tianhua Chemical Co., Ltd.	0418-6530555 2855550		China	338	69
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60

Supplier	Advantage
Fuxin Simai Chemical Technology Co., Ltd.	58
Shanghai Boyle Chemical Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
Liaoning Tianhua Chemical Co., Ltd.	69
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
Beijing Ouhe Technology Co., Ltd	60

View Lastest Price from 2-Chloro-2',4'-difluoroacetophenone manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-18	2-Chloro-1-(2,4-difluorophenyl)ethanone 51336-94-8	1kg	98%		Hefei Lbao Physical & Chemical Science Co.,Ltd
2026-03-20	2-Chloro-2',4'-difluoroacetophenone 51336-94-8	1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-04-04	2-Chloro-2',4'-difluoroacetophenone 51336-94-8	25KG	97%	1tone	Henan Aochuang Chemical Co.,Ltd.

2-Chloro-1-(2,4-difluorophenyl)ethanone
51336-94-8
$0.00
98%
Hefei Lbao Physical & Chemical Science Co.,Ltd

2-Chloro-2',4'-difluoroacetophenone
51336-94-8
99%
Hebei Chuanghai Biotechnology Co., Ltd

2-Chloro-2',4'-difluoroacetophenone
51336-94-8
$0.00
97%
Henan Aochuang Chemical Co.,Ltd.

2-Chloro-2',4'-difluoroacetophenone Spectrum

2-Chloro-2',4'-difluoroacetophenone(51336-94-8)MS 2-Chloro-2',4'-difluoroacetophenone(51336-94-8)¹HNMR 2-Chloro-2',4'-difluoroacetophenone(51336-94-8)¹³CNMR 2-Chloro-2',4'-difluoroacetophenone(51336-94-8)IR1 2-Chloro-2',4'-difluoroacetophenone(51336-94-8)IR2 2-Chloro-2',4'-difluoroacetophenone(51336-94-8)Raman

51336-94-8(2-Chloro-2',4'-difluoroacetophenone )Related Search:

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6-(1-Bromoethyl)-4-chloro-5-fluoropyrimidine Voriconazole Impurity 53 Voriconazole

1of4

2,4-difluorophenacyl chloride ,2-chloro-1-(2,4-difluorophenyl)ethanone Chloromethyl(2,4-difluorophenyl) ketone 2-CHLORO-2',4'-DIFLUOROACETOPHEONE 2-Bhloro-2',4'-difluoroacetophenone Ethanone,2-chloro-1-(2,4-difluorophenyl)- 2-Chloro-2',4'-difluoroacetophenone,98% 2-Chloro-2 [2-(2,4-difluorophenyl)-2-oxoethyl]chloranuide 2-Chloro-2',4'-difluoroacetophenone, 2-Chloro-1-(2,4-difluorophenyl)ethan-1-one Voriconazole Impurity 6(RR,SS mixture) Fluconazole Impurity 6 (2-Chloro-2’,4’-Difluoroacetophenone) 2-Chloro-2',4'-difluoroacetophenone benzenamine 2-Chloro-2',4'-difluoroacetophenone, 97+% 2-Chloro-2',4'-difluoroacetophenone 98% Voriconazole Impurity 6 2-CHLORO-1-(2,4-DIFLUOROPHENYL)ETHANONE 2'-CHLORO-2,4-DIFLUOROACETOPHENONE 2',4'-DIFLUORO-2-CHLOROACETOPHENONE 2',4'-DIFLUORO-ALPHA-CHLOROACETOPHENONE 2',4'-DIFLUORO-ALFA-CHLOROACETOPHENONE 2,4-DIFLUOROPHENACYL CHLORIDE ALPHA-CHLORO-2,4-DIFLUOROACETOPHENONE TIMTEC-BB SBB006665 2,4-Difluorophenacyl chloride 98% 2,4-Difluorophenacylchloride98% 2'-Chloro 2,4-fluoro acetophenone 2-Chloro-2,4-Difluoroacetophenone/2,4-Difluoro-2-Chloro-Acetophenone 2',4'-Diflouro-2-Chloroacetophenone a-Chloroacetyl-2,4-Difluorobenzene α -Chloro-2,4-Difluoroacetophenone 2,4-difluoro-α-chloroacetophenone 2-Chloro-2',4'-difluoroacetophenone > Voriconazole RC1 2-chloro-1-(2,4-difluorophenyl)ethanone(51336-94-8) 2,4Difluoro 1H,1yl,1,2,4Triazole Acetophenone (DFTA) 2-Chloro-2',4'-difluoroacetophenone 2',4'-DIFLUORO-2-CHLORO ACETOPHENONE (CL- COMPOUND OF DFTA IMPURITY) 51336-94-8 632-42-2 C8H5OClF2 F2C6H3COCH2Cl Organic Building Blocks Ketones C7 to C8 Carbonyl Compounds Building Blocks Acetophenone series Aromatics Inhibitors C7 to C8 Carbonyl Compounds Ketones blocks FluoroCompounds Benzene series