ChemicalBook >> CAS DataBase List >>SB-674042
SB-674042
- CAS No.
- 483313-22-0
- Chemical Name:
- SB-674042
- Synonyms
- SB-674042;SB 674042; SB674042;SB 674042 >=98% (HPLC);SB-674042, CID10204153;[5-(2-Fluorophenyl)-2-methyl-4-thiazolyl][2(S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl-1-pyrrolidinyl]methanone;Methanone, [5-(2-fluorophenyl)-2-methyl-4-thiazolyl][(2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-1-pyrrolidinyl]-;(S)-1-[5-[2-Fluorophenyl]-2-methylthiazol-4-yl]-1-[2-[[5-phenyl-[1,3,4]oxadiazol-2-yl]methyl]pyrrolidin-1-yl]methanone;[5-(2-FLUOROPHENYL)-2-METHYL-1,3-THIAZOL-4-YL]-[(2S)-2-[(5-PHENYL-1,3,4-OXADIAZOL-2-YL)METHYL]PYRROLIDIN-1-YL]METHANONE;(2S)- 1-[[5-(2-Fluorophenyl)-2-methyl-4-thiazolyl]carbonyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-pyrrolidine (9CI)
- CBNumber:
- CB92628382
- Molecular Formula:
- C24H21FN4O2S
- Molecular Weight:
- 448.51
- MDL Number:
- MFCD18251550
- MOL File:
- 483313-22-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-07-14 16:49:18
| Product description | Number | Pack Size | Price |
| SB 674042 ≥98% (HPLC) | SML0912 | 25mg | $561 |
| SB 674042 ≥98% (HPLC) | SML0912 | 5mg | $131 |
| SB-674042 ≥98% | 21270 | 1mg | $38 |
| SB-674042 ≥98% | 21270 | 5mg | $129 |
| SB-674042 ≥98% | 21270 | 10mg | $238 |
| Boiling point | 655.9±65.0 °C(Predicted) |
|---|---|
| Density | 1.326±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble10mg/mL, clear |
| pka | 0.74±0.10(Predicted) |
| form | powder |
| color | white to beige |
| InChIKey | HYBZWVLPALMACV-KRWDZBQOSA-N |
| SMILES | Fc1c(cccc1)c2[s]c(nc2C(=O)N3[C@@H](CCC3)Cc4nnc([o]4)c5ccccc5)C |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
SB-674042 price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0912 | SB 674042 ≥98% (HPLC) | 483313-22-0 | 25mg | $561 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML0912 | SB 674042 ≥98% (HPLC) | 483313-22-0 | 5mg | $131 | 2025-07-31 | Buy |
| Cayman Chemical | 21270 | SB-674042 ≥98% | 483313-22-0 | 1mg | $38 | 2026-04-30 | Buy |
| Cayman Chemical | 21270 | SB-674042 ≥98% | 483313-22-0 | 5mg | $129 | 2026-04-30 | Buy |
| Cayman Chemical | 21270 | SB-674042 ≥98% | 483313-22-0 | 10mg | $238 | 2026-04-30 | Buy |
SB-674042 Chemical Properties,Uses,Production
Uses
SB 674042 is a novel nonpeptide antagonist to OX-1.
Biochem/physiol Actions
SB-674042 is potent and selective OX1R antagonist. SB-674042 binds with high affinity to OX1R and mediates intracellular calcium flux in OX1R-expressing cells.
in vivo
SB-674042 (0.3 nM/0.3 μL; icv; single dose) reduces contextual and cues fear freezing responses in Stay animals in Stress Alternatives Model (SMA) in mice[4].
| Animal Model: | Stress-induced mice model (male C57BL/6NHsd mice, 22-26 g)[4] |
| Dosage: | 0.3 nM/0.3 μL |
| Administration: | Intracerebroventricular injection; subjected mice to 4 days of social aggression (days 1-4) |
| Result: | Resulted 39.4% Escape and 60.6% Stay phenotypes among mice. |
IC 50
OX1 Receptor: 3.76 nM (IC50); OX2 Receptor: 531 nM (IC50); OX1 Receptor: 1.1 nM (Ki); OX2 Receptor: 129 nM (Ki)
storage
Store at +4°C
SB-674042 Preparation Products And Raw materials
Raw materials
Preparation Products
SB-674042 Suppliers
Global( 75)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501 | product@acmec-e.com | China | 33301 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50108 | 58 | |
| Shaanxi Dideu New Materials Co. Ltd | 18192503167 | 1036@dideu.com | China | 13298 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Chengdu Huachun Technology Co., Ltd | 400-1166-196 15982826727 | cdhxsj@163.com | China | 14571 | 60 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4382 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27602 | 58 |
483313-22-0(SB-674042)Related Search:
[5-(2-Fluorophenyl)-2-methyl-4-thiazolyl][2(S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl-1-pyrrolidinyl]methanone
SB 674042; SB674042
SB-674042
(S)-1-[5-[2-Fluorophenyl]-2-methylthiazol-4-yl]-1-[2-[[5-phenyl-[1,3,4]oxadiazol-2-yl]methyl]pyrrolidin-1-yl]methanone
(2S)- 1-[[5-(2-Fluorophenyl)-2-methyl-4-thiazolyl]carbonyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-pyrrolidine (9CI)
[5-(2-FLUOROPHENYL)-2-METHYL-1,3-THIAZOL-4-YL]-[(2S)-2-[(5-PHENYL-1,3,4-OXADIAZOL-2-YL)METHYL]PYRROLIDIN-1-YL]METHANONE
SB-674042, CID10204153
Methanone, [5-(2-fluorophenyl)-2-methyl-4-thiazolyl][(2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-1-pyrrolidinyl]-
SB 674042 >=98% (HPLC)
483313-22-0
C24H21N4O2FS
