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SB-674042

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CAS:483313-22-0
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CAS:483313-22-0
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CAS:483313-22-0
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CAS:483313-22-0
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Products Intro: Product Name:SB-674042
CAS:483313-22-0
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  • SB-674042
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  • $45.00
  • 2026-07-14
  • CAS:483313-22-0
  • Purity: 99.82%
  • Supply Ability: 10g
  • SB-674042
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  • 2026-07-13
  • CAS:483313-22-0
  • Min. Order: 1KG
  • Purity: 98%
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SB-674042 Basic information
Product Name:SB-674042
Synonyms:[5-(2-Fluorophenyl)-2-methyl-4-thiazolyl][2(S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl-1-pyrrolidinyl]methanone;SB 674042; SB674042;SB-674042;(S)-1-[5-[2-Fluorophenyl]-2-methylthiazol-4-yl]-1-[2-[[5-phenyl-[1,3,4]oxadiazol-2-yl]methyl]pyrrolidin-1-yl]methanone;(2S)- 1-[[5-(2-Fluorophenyl)-2-methyl-4-thiazolyl]carbonyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-pyrrolidine (9CI);[5-(2-FLUOROPHENYL)-2-METHYL-1,3-THIAZOL-4-YL]-[(2S)-2-[(5-PHENYL-1,3,4-OXADIAZOL-2-YL)METHYL]PYRROLIDIN-1-YL]METHANONE;SB-674042, CID10204153;Methanone, [5-(2-fluorophenyl)-2-methyl-4-thiazolyl][(2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-1-pyrrolidinyl]-
CAS:483313-22-0
MF:C24H21FN4O2S
MW:448.51
EINECS:
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Mol File:483313-22-0.mol
SB-674042 Structure
SB-674042 Chemical Properties
Boiling point 655.9±65.0 °C(Predicted)
density 1.326±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble10mg/mL, clear
form powder
pka0.74±0.10(Predicted)
color white to beige
InChIKeyHYBZWVLPALMACV-KRWDZBQOSA-N
SMILESFc1c(cccc1)c2[s]c(nc2C(=O)N3[C@@H](CCC3)Cc4nnc([o]4)c5ccccc5)C
Safety Information
Hazard Codes Xn
Risk Statements 22
WGK Germany 3
Storage Class11 - Combustible Solids
Hazard ClassificationsAcute Tox. 4 Oral
MSDS Information
SB-674042 Usage And Synthesis
UsesSB 674042 is a novel nonpeptide antagonist to OX-1.
Biochem/physiol ActionsSB-674042 is potent and selective OX1R antagonist. SB-674042 binds with high affinity to OX1R and mediates intracellular calcium flux in OX1R-expressing cells.
in vivo

SB-674042 (0.3 nM/0.3 μL; icv; single dose) reduces contextual and cues fear freezing responses in Stay animals in Stress Alternatives Model (SMA) in mice[4].

Animal Model:Stress-induced mice model (male C57BL/6NHsd mice, 22-26 g)[4]
Dosage:0.3 nM/0.3 μL
Administration:Intracerebroventricular injection; subjected mice to 4 days of social aggression (days 1-4)
Result:Resulted 39.4% Escape and 60.6% Stay phenotypes among mice.
IC 50OX1 Receptor: 3.76 nM (IC50); OX2 Receptor: 531 nM (IC50); OX1 Receptor: 1.1 nM (Ki); OX2 Receptor: 129 nM (Ki)
storageStore at +4°C
SB-674042 Preparation Products And Raw materials
Tag:SB-674042(483313-22-0) Related Product Information
Sulfanilamide Lignosulfonic acid Angeli’s Salt TRIS(PENTAFLUOROPHENYL)PHOSPHINE 2-FLUOROPHENYL CYCLOPENTYL KETONE SB-674042