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Bexagliflozin

Bexagliflozin Structure
Bexagliflozin structure
CAS No.
1118567-05-7
Chemical Name:
Bexagliflozin
Synonyms
THR1442;(1S)-1,5-Anhydro-1-C-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-D-glucitol;CS-250;CS-2165;EGT1442;THR-1442;THR 1442;EGT0001442;EGT-0001442;EGT 0001442
CBNumber:
CB92650633
Molecular Formula:
C24H29ClO7
Molecular Weight:
464.94
MDL Number:
MFCD28100944
MOL File:
1118567-05-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-26 20:01:20
Product description Number Pack Size Price
EGT-1442 ≥95% 21359 1mg $36
EGT-1442 ≥95% 21359 5mg $153
EGT-1442 ≥95% 21359 10mg $268
EGT-1442 ≥95% 21359 25mg $587
Bexagliflozin FA145137 25mg $389.5
More product size
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Bexagliflozin Properties

Melting point 132.5-133.5 °C
Boiling point 671.0±55.0 °C(Predicted)
Density 1.41
storage temp. Store at -20°C
solubility DMSO:100.0(Max Conc. mg/mL);215.08(Max Conc. mM)
form A crystalline solid
pka 13.23±0.70(Predicted)
InChIKey BTCRKOKVYTVOLU-IZSIRFNDNA-N
SMILES [C@H]1(C2C=C(CC3C=CC(OCCOC4CC4)=CC=3)C(Cl)=CC=2)[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 |&1:0,22,24,26,28,r|
FDA UNII EY00JF42FV

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
NFPA 704
0
2 0

Bexagliflozin price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21359 EGT-1442 ≥95% 1118567-05-7 1mg $36 2026-04-30 Buy
Cayman Chemical 21359 EGT-1442 ≥95% 1118567-05-7 5mg $153 2026-04-30 Buy
Cayman Chemical 21359 EGT-1442 ≥95% 1118567-05-7 10mg $268 2026-04-30 Buy
Cayman Chemical 21359 EGT-1442 ≥95% 1118567-05-7 25mg $587 2026-04-30 Buy
Biosynth FA145137 Bexagliflozin 1118567-05-7 25mg $389.5 2026-06-04 Buy
Product number Packaging Price Buy
21359 1mg $36 Buy
21359 5mg $153 Buy
21359 10mg $268 Buy
21359 25mg $587 Buy
FA145137 25mg $389.5 Buy

Bexagliflozin Chemical Properties,Uses,Production

Description

EGT-1442 is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 5.6 μM and 2 nM for human SGLT1 and SGLT2, respectively. It produces a stable urinary excretion of glucose in rats and dogs with ED50 values of 0.38 and 0.09 mg/kg, respectively, and reduces HbA(1c) and blood glucose in db/db mice in a concentration dependent manner.

Uses

Bexagliflozin, also known as EGT1442, is a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats. EGT1442 showed favorable properties both in vitro and in vivo and could be beneficial to the management of type 2 diabetic patients.

Definition

ChEBI: Bexagliflozin is a C-glycosyl comprising of beta-D-glucose in which the anomeric hydroxy group is replaced by a 4-chloro-3-({4-[2-(cyclopropyloxy)ethoxy]phenyl}methyl)phenyl group. It is a sodium-glucose co-transporter 2 (SGLT2) inhibitor indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It has a role as a sodium-glucose transport protein subtype 2 inhibitor, a hypoglycemic agent and an antihypertensive agent. It is a C-glycosyl compound, an aromatic ether, a member of monochlorobenzenes, a diether and a member of cyclopropanes.

Mechanism of action

Bexagliflozin is a highly selective inhibitor of sodium-glucose cotransporter protein 2 (SGLT2), which cotransports sodium and glucose from the filtrate to the epithelium of the proximal renal tubule, thereby lowering the tubular glucose reabsorption threshold, reducing renal glucose reabsorption, and increasing urinary glucose excretion without affecting insulin levels.

Synthesis

(3R,4S,5S,6R)-2-(4-chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

1459754-30-3

Bexagliflozin

1118567-05-7

Example 5: Preparation of (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol [0236] This embodiment describes the preparation of (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol by reduction of end-isomers OMe and/or OH. Procedure. 1. Add (3R,4S,5S,6R)-2-(4-chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol crude (2.7 kg), dichloromethane (5.4 kg), and acetonitrile (3.2 kg) to a 30L glass reactor under nitrogen protection with magnetic stirred until complete dissolution. 2. In another vessel, boron trifluoride ethyl ether complex (2.34 kg) was added dropwise to a mixture of dichloromethane (5.4 kg) and acetonitrile (3.2 kg) of triethylsilane (2.55 kg) at -21 to -15 °C, maintaining a nitrogen atmosphere. 3. The feedstock solution prepared in step 1 was slowly added to the cold solution in step 2, and the addition rate was controlled to maintain the reaction temperature between -20 and -25°C (about 3 hours). After addition, the reaction continues to be stirred at -22 to -25°C for 4 hours. 4. Upon completion of the reaction, the reaction was quenched by the slow addition of 7.4% w/w aqueous sodium bicarbonate (18.3 kg), controlling the internal temperature to no more than -10°C. The reaction was then quenched by the addition of solid sodium bicarbonate (18.3 kg). Subsequently, solid sodium bicarbonate (1.35 kg) was added to adjust the pH to 7.5. 5. The solvent was removed by depressurized concentration (temperature < 40 °C) and the residue was partitioned with ethyl acetate (18 kg) and water (9.2 kg). The organic phase was separated and the aqueous phase was extracted with ethyl acetate (2 x 9 kg). The organic layers were combined and washed with saturated brine (2 x 9 kg). 6. The organic phase was concentrated to near dryness (temperature < 40 °C) under pressure, added anhydrous ethanol (9 kg) and concentrated again to give the crude product (2.5 kg, yield 90%, HPLC purity 90.8%, method HPLC-0001) as a foamy solid.

References

[1] Patent: US2013/267694, 2013, A1. Location in patent: Paragraph 0236; 0237; 0238; 0239; 0240; 0241
[2] Tetrahedron Letters, 2016, vol. 57, # 42, p. 4684 - 4687
[3] Patent: WO2013/152476, 2013, A1. Location in patent: Paragraph 0206; 0207; 0208; 0209; 0210
[4] Patent: WO2013/152654, 2013, A1. Location in patent: Paragraph 0212-0216

Bexagliflozin synthesis

1459754-30-3
1118567-05-7
Synthesis of Bexagliflozin from (3R,4S,5S,6R)-2-(4-chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

Bexagliflozin Preparation Products And Raw materials

Raw materials

2-Cyclopropoxyethyl4-methylbenzenesulfonate 2-(2-Bromoethyl)-1,3-dioxolane (3R,4S,5S,6R)-2-(4-chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol ((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate 4-broMo-1-chloro-2-(4-(2-cyclopropoxyethoxy)benzyl)benzene
4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene 4-(5-broMo-2-chlorobenzyl)phenol 5-Bromo-2-chlorobenzoic acid D-Glucono-1,5-lactone Acetonitrile

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Preparation Products

Bexagliflozin Suppliers

Global( 164)Suppliers
Supplier Tel Email Country ProdList Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-15225627621 +86-13213167925 jiuyitime@fdachem.com China 16505 58
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19935 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
Zhengzhou Alfa Chemical Co.,Ltd 		+86-18530059196 sale04@alfachem.cn China 9694 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Chemsigma International Co., Ltd. 		+86-2558742998 +86-19951791336 info@chemsigma.com China 1824 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 sales@sarms4muscle.com China 10378 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 +8619957148339 market18@leapchem.com China 24569 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 38999 58
Supplier Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		58
career henan chemical co 		58
BOC Sciences 		58
CONIER CHEM AND PHARMA LIMITED 		58
Zhengzhou Alfa Chemical Co.,Ltd 		58
TargetMol Chemicals Inc. 		58
Chemsigma International Co., Ltd. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
TargetMol Chemicals Inc. 		58

View Lastest Price from Bexagliflozin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Bexagliflozin pictures 2026-09-04 Bexagliflozin
1118567-05-7
 1kg 99.0 100kg Jinan Hong Kongda Chemical Co.,LTD
Bexagliflozin pictures 2026-09-04 Bexagliflozin
1118567-05-7
 $2.00 99% 200KG Jinan Million Pharmaceutical Co., Ltd
Bexagliflozin pictures 2026-08-25 Bexagliflozin
1118567-05-7
 $2.20-8.80 1KG 99% ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
  • Bexagliflozin pictures
  • Bexagliflozin
    1118567-05-7
  • $0.00
  • 99.0
  • Jinan Hong Kongda Chemical Co.,LTD
  • Bexagliflozin pictures
  • Bexagliflozin
    1118567-05-7
  • $2.00
  • 99%
  • Jinan Million Pharmaceutical Co., Ltd
  • Bexagliflozin pictures
  • Bexagliflozin
    1118567-05-7
  • $2.20-8.80
  • 99%
  • ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Bexagliflozin Spectrum

Bexagliflozin(1118567-05-7)1HNMR

1118567-05-7(Bexagliflozin)Related Search:

(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4- hydroxybenzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate Furan, 3-[4-[(2-chlorophenyl)methyl]phenoxy]tetrahydro-, (3S)- D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-, 2,3,4,6-tetrakis(2,2-dimethylpropanoate), (1S)- Dapagliflozin Open Ring Ortho-Isomer of Dapagliflozin
Dapagliflozin Impurity D

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EGT1442 Bexagliflozin EGT1442(Bexagliflozin,THR1442) Bexagliflozin，EGT1442 CS-2165 EGT 0001442 EGT0001442 EGT-0001442 EGT1442; THR1442; EGT0001442; EGT-1442; THR-1442; EGT-0001442; EGT 1442; THR 1442; EGT 0001442 THR 1442 THR-1442 CS-250 Bexagliflozin(THR1442,EGT1442)| BEXAGLIFLOZIN;EGT-1442;THR1442;EGT0001442;EGT-1442;THR-1442;EGT-0001442;EGT 1442;THR 1442;EGT 0001442 Bexagliflozin (THR1442) D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-, (1S)- Bexagliflozin3 Bexgliflozin (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol Bexagliflozin Impurity 1 Bexgliflozin (EGT1442) Bexgliflozin Impurity 1 Bexagliflozin, 10 mM in DMSO Bexagliflozin (EGT1442) ，E0141 Beisha Gelejing (1S)-1,5-Anhydro-1-C-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-D-glucitol THR1442 1118567-05-7 118567-05-7