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4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene

4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene structure

CAS No.: 461432-23-5

Chemical Name:: 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene

Synonyms: 5-bromo-2-chloro-4’-ethoxydiphenylmethane;4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]benzene;Benzene, 4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]-;1-(5-broMo-2-chlorobenzyl)-4-ethoxybenzene;4-(Dibenzofuranyl)boronic;Dapagliflozin Bromo impurity;5-bromo-2-chloro-4'-ethoxydiphenylmethane;4-(5-Bromo-2-chlorobenzyl)phenyl ethyl ether;Dapagliflozin-13;Dapaglifozin DAP Bromo

CBNumber:: CB71456759

Molecular Formula:: C15H14BrClO

Molecular Weight:: 325.63

MDL Number:: MFCD11042292

MOL File:: 461432-23-5.mol

MSDS File:: SDS

Last updated:2026-05-28 02:48:41

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4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene Properties

Boiling point	393.0±32.0 °C(Predicted)
Density	1.371±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
form	Low-Melting Solid
color	White to Off-White
Stability	Stable under recommended storage conditions., Stable Under Recommended Storage C
InChI	InChI=1S/C15H14BrClO/c1-2-18-14-6-3-11(4-7-14)9-12-10-13(16)5-8-15(12)17/h3-8,10H,2,9H2,1H3
InChIKey	ZUNCHZBITMUSRD-UHFFFAOYSA-N
SMILES	C1(Cl)=CC=C(Br)C=C1CC1=CC=C(OCC)C=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338
HS Code	2909309090
REACH Registrations	Active

4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene price More Price(52)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	B7018	4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene	461432-23-5	25G	$33	2026-04-30	Buy
TCI Chemical	B7018	4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene	461432-23-5	250G	$195	2026-04-30	Buy
Biosynth	FB76075	4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene	461432-23-5	0.5kg	$900	2026-06-04	Buy
Biosynth	FB76075	4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene	461432-23-5	1kg	$900	2026-06-04	Buy
Biosynth	FB76075	4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene	461432-23-5	2kg	$962.5	2026-06-04	Buy

Product number	Packaging	Price	Buy
B7018	25G	$33	Buy
B7018	250G	$195	Buy
FB76075	0.5kg	$900	Buy
FB76075	1kg	$900	Buy
FB76075	2kg	$962.5	Buy

4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene Chemical Properties, Uses, Production

Uses

5-Bromo-2-chloro-4'-ethoxydiphenylmethane is a hydrocarbon derivative and can be used as an intermediate for dapagliflozin.

Synthesis

Oxalyl chloride (0.8 mL) was added to a solution of 5-bromo-2-chlorobenzoic acid (2 g) in dichloromethane (20 mL) and dimethylformamide (0.2 mL) under a nitrogen atmosphere. The reaction mixture was stirred for one hour at 25° C to 30° C. After completion of the reaction, the reaction mixture was concentrated under a vacuum at 40° C to 45° C. to obtain an oily residue. The oily residue was dissolved in dichloromethane (20 mL) and cooled to 0° C. To this solution, phenol (1.1 mL) and aluminium chloride (2.3 g) were added at 0° C. to 5° C. The reaction mixture was stirred at 0° C to 5° C for 2 hours. The reaction mixture was allowed to warm to about 20° C, and triethylsilane (3.4 mL) was slowly added to it at the same temperature. The reaction mixture was stirred for about 36 hours from 20° C to 25° C. After completion of the reaction, 4-bromo-1-chloro-2-(4-ethoxybenzyl)benzene was obtained by further purification.

4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene synthesis

Synthesis of 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene from (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone

4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene Preparation Products And Raw materials

Raw materials

Preparation Products

(2S,3R,4S,5S)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6,6-bis(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol Bexagliflozin 4-(5-broMo-2-chlorobenzyl)phenol

4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene Suppliers

Global Suppliers ( 620)

Supplier	Tel	Email	Country	ProdList	Advantage
Jinan Chenghui Shuangda biological Co., LTD	053158897070 15550412551	market@jnchsd.com	China	224	62
Jiangsu Vcare PharmaTech Co., Ltd.	025-58741518 13327700685	sales@vcarepharmatech.com	China	281	61
CHENGHUI PHARMACEUTICAL GROUP LTD	053158897070 15550412551	market@jnchsd.com	China	241	58
Gansu HaoTian Chemical Technology Co., Ltd.	0943-6900332 17789447501	zhuanxiajiang@haotianpharm.com	China	182	55
EVERSHINE CHEMICAL CO., LIMITED	17185714011	3506894070@qq.com	China	119	58
Anhui Dexinjia Biopharm Co., Ltd	0531-82375893 15553111391	phoebe@jndxj.com	China	285	58
Anqing CHICO Pharmaceutical Co., Ltd.	18061456370	sales@chicopharm.com	China	500	65
Nan Ping XuhHong Chemical Co. Ltd	15159460808 13905998146	kobe@xuhongchem.com	China	33	58
Jiangsu Haici Biopharmaceutical Co., Ltd.	15722465851 15722465851	2545001360@qq.com	China	183	58
Beijing Huikang Boyuan Chemical Tech Co., Ltd	010-68862197 13810598707;13810598707	sales@huikangchem.com	China	97	61

Supplier	Advantage
Jinan Chenghui Shuangda biological Co., LTD	62
Jiangsu Vcare PharmaTech Co., Ltd.	61
CHENGHUI PHARMACEUTICAL GROUP LTD	58
Gansu HaoTian Chemical Technology Co., Ltd.	55
EVERSHINE CHEMICAL CO., LIMITED	58
Anhui Dexinjia Biopharm Co., Ltd	58
Anqing CHICO Pharmaceutical Co., Ltd.	65
Nan Ping XuhHong Chemical Co. Ltd	58
Jiangsu Haici Biopharmaceutical Co., Ltd.	58
Beijing Huikang Boyuan Chemical Tech Co., Ltd	61

4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene: Building Block for Cross-Coupling
4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene is a diphenylmethane building block for cross-coupling reactions and used in downst....
Mar 22,2026

Synthesis and Coupling reaction of 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene
4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene is primarily used as a synthetic intermediate for the drug molecule dapagliflozin.
Jan 20,2026

View Latest Price from 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-18	5-bromo-2-chloro-4’-ethoxydiphenylmethane 461432-23-5	$666.00-999.00	1kg	99%	5000	HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
2026-09-18	5-bromo-2-chloro-4’-ethoxydiphenylmethane 461432-23-5		1kg	98%-101%	1000kg	WUHAN FORTUNA CHEMICAL CO., LTD
2026-09-18	5-bromo-2-chloro-4’-ethoxydiphenylmethane 461432-23-5			0.99		RongNa Biotechnology Co.,Ltd

5-bromo-2-chloro-4’-ethoxydiphenylmethane
461432-23-5
$666.00-999.00
99%
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

5-bromo-2-chloro-4’-ethoxydiphenylmethane
461432-23-5
98%-101%
WUHAN FORTUNA CHEMICAL CO., LTD

5-bromo-2-chloro-4’-ethoxydiphenylmethane
461432-23-5
0.99
RongNa Biotechnology Co.,Ltd

4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene Spectrum

4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene(461432-23-5)¹HNMR

461432-23-5 (4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene) Related Search:

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene (R)-3-(4-(5-broMo-2-chlorobenzyl)phenoxy)tetrahydrofuran 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone 4-(5-broMo-2-chlorobenzyl)phenol 2,3,4,6-Tetra-O-pivaloyl-alpha-D-glucopyranosyl bromide

2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene Empagliflozin Canagliflozin heMihydrate PF-04971729 Ipragliflozin

Canagliflozin Donepezil 1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene 5-Bromo-2-chlorobenzoic acid (5-broMo-2-chlorophenyl)(2-ethoxyphenyl)Methanone

(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone 4-Bromo-1-chloro-2-ethylbenzene 5-bromo-2-chloro-4’-ethoxydiphenylmethane

1of4

Dapagliflozin Intermediate 1 4-broMo-1-chloro-2-[(4-ethoxyphenyl)Methyl]- 2-(4-Methoxybenzyl)-4-broMo-1-chlorobenzene Dapagliflozin-13 Dapagliflozin Bromo impurity 5-broMo-2-chloro-4&rsquo Dapagliflozin Intermediate II Dapagliflozin Intermediate 2 5-bromo-2-chloro-4'-ethoxydiphenylmethane###461432-23-5 (5-bromo-2-chlorobenzyl)-4-ethoxybenzene 4-(5-Brom-2-chlorbenzyl)phenyl-ethylether Dapagliflozin Impurity 15 4-(5-Bromo-2-chlorobenzy)phenylethyl ester Dapagliflozin Impurity 82 4-Bromo-1-chloro-2-(4-ethoxybenzyl) Dapagliflozin Despyranose Bromo Impurity 4-Brom-1-chlor-2-(4-ethoxybenzyl)benzol 5-bromo-2-chloro-4’-ethoxydiphenylmethane ISO 9001：2015 REACH 4-(3-((1-ethoxyethoxy)methyl)-4-bromophenoxy)benzonitrile Supply 5-bromo-2-chloro-4'-ethoxydiphenylmethane Dapaglifozin DAP Bromo 5-bromo-2-chloro-4-ethoxydiphenylmethaneQ: What is 5-bromo-2-chloro-4-ethoxydiphenylmethane Q: What is the CAS Number of 5-bromo-2-chloro-4-ethoxydiphenylmethane Q: What is the storage condition of 5-bromo-2-chloro-4-ethoxydiphenylmethane Q: What are the applications of 5-bromo-2-chloro-4-ethoxydiphenylmethane Dapagliflozin Intermediate/ 5-Bromo-2-Chloro-4'-Ethoxydiphenylmethane 4-(5- bromo -2- chlorobenzyl) phenethyl ether 4-Bromo-1-ChIoro 2-4-EthoxybenzyI-Benzene 5-Bromo-2-chIoro-4’-ethoxydiphenyImethane 4-bromo-l-chloro-2-(4-ethoxybenzyl)benzene 2-(4-ethoxybenzyl)-4-bromo-1-chloro benzene 5-bromo-2-chloro-4’-ethoxydiphenylmethane, Or 4-(5-Bromo-2-chlorobenzyl)phenyl ethyl ether (5-Bromo-2-chlorobenzyl)phenyl ethyl ether 6-bromo-2-chloro-4’-ethoxydiphenylmethane 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene 5-bromo-2-chloro-4’-ethoxydiphenylmethan 5-Bromo-2-chloro-4'-oxydiphenylmethane 5-bromo-2-chloro-4' -ethoxydiphenylmethane 4-Eroma-1-chloro-2-(4-ethoxybenzyl'benzene L-pyroglutamate etoglipflozin impurities 31 Dapagliflozin impurity: 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene 1-(5-broMo-2-chlorobenzyl)-4-ethoxybenzene 4-(5-Bromo-2-chlorobenzyl)phenyl ethyl ether 4-(Dibenzofuranyl)boronic 4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]benzene 5-bromo-2-chloro-4’-ethoxydiphenylmethane 5-bromo-2-chloro-4'-ethoxydiphenylmethane Benzene, 4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]- 4-(5-bromo-2-chlorobenzyl)phenyl ethyl ether fandachem 461432-23-5 61432-23-5 100134-06-9 9461432-23-5 C15H14BrClO Halides Phenyls & Phenyl-Het 461432-23-5 ADVANCED INT.