Bexagliflozin NEW

Bexagliflozin

Modify Date: 2024-01-02 11:31:57

Bexagliflozin structure	Common Name	Bexagliflozin
	CAS Number	1118567-05-7	Molecular Weight	464.936
	Density	1.4±0.1 g/cm3	Boiling Point	671.0±55.0 °C at 760 mmHg
	Molecular Formula	C24H29ClO7	Melting Point	N/A
	MSDS	N/A	Flash Point	359.6±31.5 °C

Purity		Quantity		Budget		Inquiry

Use of Bexagliflozin Bexagliflozin is a potent and selective SGLT2 inhibitor with IC50 value of 5.6 μM /2 nM in SGLT1 /SGLT2 respectively.target: SGLT2IC50: 5.6 μM (SGLT1)/ 2 nM (SGLT2)1) In normal rats and dogs a saturable urinary glucose excretion was produced with an ED50 of 0.38 and 0.09 mg/kg, respectively.2) EGT1442 significantly prolonged the median survival of SHRSP rats.3) EGT1442 dose-dependently reduced HbA1c and blood glucose concentration without affecting body mass or insulin level.

• Properties

• Spectrum

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 Names

Name	(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
Synonym	More Synonyms

 Bexagliflozin Biological Activity

Description	Bexagliflozin is a potent and selective SGLT2 inhibitor with IC50 value of 5.6 μM /2 nM in SGLT1 /SGLT2 respectively.target: SGLT2IC50: 5.6 μM (SGLT1)/ 2 nM (SGLT2)1) In normal rats and dogs a saturable urinary glucose excretion was produced with an ED50 of 0.38 and 0.09 mg/kg, respectively.2) EGT1442 significantly prolonged the median survival of SHRSP rats.3) EGT1442 dose-dependently reduced HbA1c and blood glucose concentration without affecting body mass or insulin level.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> SGLT Research Areas >> Metabolic Disease
References	[1]. Zhang W et al. EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats. Pharmacol Res. 2011 Apr;63(4):284-93.

 Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	671.0±55.0 °C at 760 mmHg
Molecular Formula	C24H29ClO7
Molecular Weight	464.936
Flash Point	359.6±31.5 °C
Exact Mass	464.160187
PSA	108.61000
LogP	3.92
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.642
Storage condition	2-8℃

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