ChemicalBook >> CAS DataBase List >>(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester
(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester
- CAS No.
- 1168150-46-6
- Chemical Name:
- (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester
- Synonyms
- methyl (E)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate;(3E)-2;Nintedanib-017;BIBF1120 Intermediate4;Nintedanib impurities3;Nintedanib Impurity 125;Nintedanib Intermediate 4;Nintedanib ethanesulfonate intermediates;oxo-1h-indole-6-carboxylic acid methyl ester;3E-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-...
- CBNumber:
- CB92671010
- Molecular Formula:
- C18H15NO4
- Molecular Weight:
- 309.32
- MDL Number:
- MFCD28139165
- MOL File:
- 1168150-46-6.mol
Last updated:2026-05-28 04:58:41
(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Properties
| Boiling point | 523.8±50.0 °C(Predicted) |
|---|---|
| Density | 1.273±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 10.62±0.20(Predicted) |
| form | Solid |
| color | Light Yellow |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| REACH Registrations | Active |
(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 448004 | (E)-Methyl 3-(Methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate | 1168150-46-6 | 100mg | $403 | 2026-06-03 | Buy |
| Usbiological | 448004 | (E)-Methyl 3-(Methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate | 1168150-46-6 | 250mg | $638 | 2026-06-03 | Buy |
| TRC | TRC-M322025-500MG | (E)-Methyl 3-(Methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate | 1168150-46-6 | 500mg | $542 | 2026-06-03 | Buy |
| TRC | TRC-M322025-250MG | (E)-Methyl 3-(Methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate | 1168150-46-6 | 250mg | $288 | 2026-06-03 | Buy |
| TRC | TRC-M322025-100MG | (E)-Methyl 3-(Methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate | 1168150-46-6 | 100mg | $140 | 2026-06-03 | Buy |
(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Chemical Properties, Uses, Production
Uses
(E)-Methyl 3-(Methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate is an intermediate of (E)-Intedanib [I666670]. It is also used as a reactant in the preparation of deuterated derivatives of Nintedanib (N478290), which is angiokinase inhibitor with antitumor activity.
Synthesis
1174335-83-1
1168150-46-6
1. Methyl (3E)-1-(2-chloroacetyl)-2,3-dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylate (390.0 g, 1.0109 mol) was suspended in methanol (1562 mL) and heated to reflux. 2. A solution of potassium hydroxide (23.35 g, 0.35 equiv) in methanol (196.8 mL) was added slowly and the reaction was stirred for 40 minutes at reflux. 3. After the reaction is complete, the reaction mixture is cooled to 5 °C and stirring is continued for 30 min to promote product precipitation. 4. The precipitated product was collected by filtration, washed with cold methanol and subsequently dried under vacuum to afford methyl (E)-3-(methoxy(phenyl)methylene)-2-oxo dihydroindole-6-carboxylate 292.2 g in 93.5% yield.
References
[1] Patent: WO2012/68441, 2012, A2. Location in patent: Page/Page column 12; 13
[2] Patent: CN104003925, 2016, B. Location in patent: Paragraph 0161; 0163; 0178; 0179
(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester synthesis
Synthesis of (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester from Nintedanib
(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Preparation Products And Raw materials
(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester Suppliers
Global Suppliers ( 171)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9509 | 58 |
| TargetMol Chemicals Inc. | 021-021-33632979 15002134094 | marketing@targetmol.com | China | 7993 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Chengdu Climb Pharmaceutical Technology Co., Ltd. | 028-87608726 13540107218 | sales@cdclimb.com | China | 104 | 58 |
| Jinan XuanDe Chemical Co., Ltd. | 0531-88803958 19862127196 | zhangxu@shiningpharm.com | China | 202 | 58 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Shanghai SE Pharm Co., Ltd | 18112588827 | sales4@sepharm.com.cn | China | 285 | 60 |
| Lihe Wuhan New Chemical Materials Co., Ltd. | 027-88395709 | China | 427 | 50 | |
| Changzhou Fang Nan Medical Technology Co., Ltd. | 0519-85283268 | China | 116 | 55 |
View Latest Price from (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-06-08 | (E)-Methyl 3-(Methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
1168150-46-6
|
1kg | 99% | 1 | Jinan Ruitong Biotech Co., Ltd. | ||
 |
2025-04-04 | (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester
1168150-46-6
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
||
 |
2024-11-26 | (E)-methyl 3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
1168150-46-6
|
1kg | 98% | 1 ton | Nanjing Fred Technology Co., Ltd |
-
- (E)-Methyl 3-(Methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
1168150-46-6
- 99%
- Jinan Ruitong Biotech Co., Ltd.
-
- (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester
1168150-46-6
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- (E)-methyl 3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
1168150-46-6
- 98%
- Nanjing Fred Technology Co., Ltd
1168150-46-6 ((3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester) Related Search:
Methyl 2-oxoindole-6-carboxylate
1-Chloro-4-(trimethoxymethyl)benzene
Methyl 1-acetyl-2-oxoindoline-6-carboxylate
N-methyl-N-(4-nitrophenyl)-2-(piperazin-1-yl)acetamide
N-methyl-N-(4-nitrophenyl)-2-(piperazin-1-yl)acetamide
BIBF 1202
(Z)-methyl 3-(((4-(methylamino)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
Avibactam sodium
Nintedanib
1-(2-chloroacetyl)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester
1of4
(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester
BIBF1120 Intermediate4
Nintedanib ethanesulfonate intermediates
(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl este
1H-Indole-6-carboxylic acid, 2,3-dihydro-3-(methoxyphenylmethylene)-2-oxo-, methyl ester, (3E)-
Nintedanib Intermediate 4
(3E)-2
3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester
Nintedanib-017
oxo-1h-indole-6-carboxylic acid methyl ester
Nintedanib Impurity 125
3E-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-...
Nintedanib impurities3
3-[1-Methoxy-1-phenyl-meth-(E)-ylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester
Methyl (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylate
methyl (E)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
1168150-46-6
