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N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide

N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide Structure
N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide structure
CAS No.
262368-30-9
Chemical Name:
N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide
Synonyms
N-(4-Aminophenyl)-N,4-dimethyl-1-piperazineacetamide;Nidanib Impurities 61;Nintedanib Impurity 136;Nintedanib Intermediate 2;-N-methyl-2-(4-methylpiperazin-1-yl);N-(4-aminophenyl)-N-4-dimethyl-1-peperazineacetamide;N-(4-Aminophenyl)-N,4-dimethylpiperazine-1-acetamide;1-Piperazineacetamide, N-(4-aminophenyl)-N,4-dimethyl-;N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide;N-(4-Aminophenyl)-N-methyl-2-(4-methyl-1-piperazinyl)acetamide
CBNumber:
CB32520769
Molecular Formula:
C14H22N4O
Molecular Weight:
262.35
MDL Number:
MFCD12457658
MOL File:
262368-30-9.mol
MSDS File:
SDS
Last updated:2026-05-28 01:06:21
Product description Number Pack Size Price
N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide TRC-A628740-250MG 250mg $118
N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide TRC-A628740-100MG 100mg $71
N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide MKA36830 100g $688
N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide MKA36830 250g $892.5
N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide MKA36830 500g $1515
More product size
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N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide Properties

Melting point 152 - 154°C
Boiling point 434.8±40.0 °C(Predicted)
Density 1.151
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 7.43±0.10(Predicted)
color Off-White to Pale Beige
InChI InChI=1S/C14H22N4O/c1-16-7-9-18(10-8-16)11-14(19)17(2)13-5-3-12(15)4-6-13/h3-6H,7-11,15H2,1-2H3
InChIKey LBWNQLVDYPNHAV-UHFFFAOYSA-N
SMILES N1(CC(N(C2=CC=C(N)C=C2)C)=O)CCN(C)CC1
UNSPSC Code 12352200
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H315-H318-H412
Precautionary statements  P501-P273-P264-P280-P302+P352-P362+P364-P332+P313-P305+P351+P338+P310
WGK Germany  WGK 2
HS Code  2933998090
Storage Class 11 - Combustible Solids
REACH Registrations Active

N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC TRC-A628740-250MG N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide 262368-30-9 250mg $118 2026-06-03 Buy
TRC TRC-A628740-100MG N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide 262368-30-9 100mg $71 2026-06-03 Buy
Biosynth MKA36830 N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide 262368-30-9 100g $688 2026-06-04 Buy
Biosynth MKA36830 N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide 262368-30-9 250g $892.5 2026-06-04 Buy
Biosynth MKA36830 N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide 262368-30-9 500g $1515 2026-06-04 Buy
Product number Packaging Price Buy
TRC-A628740-250MG 250mg $118 Buy
TRC-A628740-100MG 100mg $71 Buy
MKA36830 100g $688 Buy
MKA36830 250g $892.5 Buy
MKA36830 500g $1515 Buy

N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide Chemical Properties,Uses,Production

Uses

N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide acts as a reagent for the preparation, angiokinase inhibitory, antitumor activity and pharmacokinectic properties of deuterated derivatives of nintedanib.

Synthesis

1-Methylpiperazine

109-01-3

2-CHLORO-N-METHYL-N-(4-NITROPHENYL)ACETAMIDE

2653-16-9

N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide

262368-30-9

GENERAL STEPS: 2-Chloro-N-methyl-N-(4-nitrophenyl)acetamide (210.0 g, 0.9185 mol) was suspended in toluene (1157.56 mL) and heated to 40 °C. The mixture was then purified by aqueous solution of N-methylpiperazine (252.65 mL, 2.48 eq.). N-methylpiperazine (252.65 mL, 2.48 eq.) was added dropwise over 30 min. The reaction mixture was stirred at 55 °C for 2 hours. After cooling to room temperature, the reaction mixture was washed with water (157.23 mL) and the organic layer was diluted with isopropanol (1075.33 mL). Palladium/carbon catalyst (18.81 g) was added and hydrogenated overnight at 20 °C under 1 bar hydrogen pressure. After the reaction was complete, the catalyst was removed by filtration and the filtrate was concentrated to about 150 mL and ground with ether (120.0 mL). The crystalline product was collected by filtration, washed with ether and dried under vacuum to afford N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide 170 g (70.5% yield).

References

[1] Patent: WO2012/68441, 2012, A2. Location in patent: Page/Page column 13; 14

N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide synthesis

109-01-3
79-04-9
100-15-2
262368-30-9
Synthesis of N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide from 1-Methylpiperazine and Chloroacetyl chloride and N-Methyl-4-nitroaniline

N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide Preparation Products And Raw materials

Raw materials

N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide 1-Methylpiperazine Chloroacetyl chloride 2-CHLORO-N-METHYL-N-(4-NITROPHENYL)ACETAMIDE N-Methyl-4-nitroaniline
Toluene Hydrogen Isopropyl alcohol

1of2

Preparation Products

(Z)-methyl 3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate Nintedanib

N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide Suppliers

Global( 294)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21533 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
Zhejiang ZETian Fine Chemicals Co. LTD 		18957127338 stella@zetchem.com China 2993 58
Jinan Finer Chemical Co., Ltd 		+86-531-88989536 +86-15508631887 sales@finerchem.com China 2949 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19935 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
Fuxin Pharmaceutical 		+86-021-021-50872116 contact@fuxinpharm.com China 9976 58
Neostar United (Changzhou) Industrial Co., Ltd. 		+86-0519-85551759 marketing1@neostarunited.com China 8827 58
Shanghai UCHEM Inc. 		+86-18930848214 +86-021-56762820 sales@myuchem.com China 8898 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Zhejiang ZETian Fine Chemicals Co. LTD 		58
Jinan Finer Chemical Co., Ltd 		58
BOC Sciences 		58
CONIER CHEM AND PHARMA LIMITED 		58
Fuxin Pharmaceutical 		58
Neostar United (Changzhou) Industrial Co., Ltd. 		58
Shanghai UCHEM Inc. 		58

View Lastest Price from N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide pictures 2025-04-04 N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide
262368-30-9
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide pictures 2024-11-26 N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide
262368-30-9
 1kg 98% 1 ton Nanjing Fred Technology Co., Ltd
N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide pictures 2022-02-25 N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide
262368-30-9
 $100.00 1KG 98% 10KG Hong Kong Tiansheng New Material Trading Co., Ltd

262368-30-9(N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide)Related Search:

Methyl 2-oxoindole-6-carboxylate (3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester 2-CHLORO-N-METHYL-N-(4-NITROPHENYL)ACETAMIDE 2-broMo-N-Methyl-N-(4-nitrophenyl)acetaMide N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide
1,3-DiMethyl 2-[4-(Methoxycarbonyl)-2-nitrophenyl]propanedioate Nintedanib esylate CHOLESTEROL ESTERASE Ethylamine FARNESENE
N-Aminoethylpiperazine 1-Methylpiperazine N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methacrylamide N'-(4-Amino-2-cyanophenyl)-N,N-dimethylformamidine BIBF-1120
1-Ethylpiperazine 1-Acetylpiperazine 4-Methylmorpholine

1of4

N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide N-(4-Aminophenyl)-N,4-dimethyl-1-piperazineacetamide N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine -N-methyl-2-(4-methylpiperazin-1-yl) Nintedanib Intermediate 2 N-(4-aminophenyl)-N-4-dimethyl-1-peperazineacetamide N-(4-Aminophenyl)-N-methyl-2-(4-methyl-1-piperazinyl)acetamide 1-Piperazineacetamide, N-(4-aminophenyl)-N,4-dimethyl- N-(4-Aminophenyl)-N,4-Dimethyl-1-Piperazineacetamide(Under Development) N- (4-aminophenyl) -N-methyl-2 - (4-methylpiperazine-1-yl) acetamide N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetami... N-(4-Aminophenyl)-n-methyl-2-(4-methylpiperazin-1-yl)acetamide 95% N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl) acetamide(Nintedanib acetamide compound) Nidanib Impurities 61 Nintedanib Impurity 136 N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide N-(4-Aminophenyl)-N,4-dimethylpiperazine-1-acetamide N-(4-Aminophenyl)-n-methyl-2-(4-methylpiperazin-1-yl)acetamide 95% 262368-30-9 Intermediate of BIBF-1120 and PKI587 262368-30-9