2-Bromo-6-(difluoromethyl)pyridine
- CAS No.
- 872365-91-8
- Chemical Name:
- 2-Bromo-6-(difluoromethyl)pyridine
- Synonyms
- 2-Bromo-6-(difluoromethyl)pyridine;Pyridine, 2-bromo-6-(difluoromethyl)-;2-Bromo-6-(difluoromethyl)pyridine 95%;2-Bromo-6-(difluoromethyl)pyridine 95+%;6-Bromo-alpha,alpha-difluoro-2-picoline
- CBNumber:
- CB92688340
- Molecular Formula:
- C6H4BrF2N
- Molecular Weight:
- 208
- MDL Number:
- MFCD16140194
- MOL File:
- 872365-91-8.mol
| Density | 1.703 g/mL at 25 °C |
|---|---|
| refractive index | 1.520 |
| Flash point | 110℃ |
| storage temp. | 2-8°C |
| form | liquid |
| Appearance | Colorless to light yellow Liquid |
| InChI | InChI=1S/C6H4BrF2N/c7-5-3-1-2-4(10-5)6(8)9/h1-3,6H |
| InChIKey | ZTBGDNNRDRISQZ-UHFFFAOYSA-N |
| SMILES | C1(Br)=NC(C(F)F)=CC=C1 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H315-H319 |
| Precautionary statements | P301+P310+P330-P302+P352-P305+P351+P338 |
| Hazard Codes | T |
| Risk Statements | 25-36/37/38 |
| Safety Statements | 26-45 |
| RIDADR | UN 2810 6.1 / PGIII |
| WGK Germany | 3 |
| HazardClass | 6.1 |
| HS Code | 2933399990 |
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) |
2-Bromo-6-(difluoromethyl)pyridine price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 741302 | 2-Bromo-6-(difluoromethyl)pyridine 95% | 872365-91-8 | 1g | $53.5 | 2025-07-31 | Buy |
| TRC | B699780 | 2-Bromo-6-(difluoromethyl)pyridine | 872365-91-8 | 500mg | $110 | 2021-12-16 | Buy |
| AK Scientific | 1187AF | 2-Bromo-6-(difluoromethyl)pyridine | 872365-91-8 | 1g | $116 | 2021-12-16 | Buy |
| Apolloscientific | PC49145 | 2-Bromo-6-(difluoromethyl)pyridine 95+% | 872365-91-8 | 5g | $127 | 2021-12-16 | Buy |
| Apolloscientific | PC49145 | 2-Bromo-6-(difluoromethyl)pyridine 95+% | 872365-91-8 | 1g | $28 | 2021-12-16 | Buy |
2-Bromo-6-(difluoromethyl)pyridine Chemical Properties,Uses,Production
Synthesis
34160-40-2
872365-91-8
Step 3. Preparation of 2-bromo-6-(difluoromethyl)pyridine To a solution of 6-bromopyridine-2-carbaldehyde (2.10 g, 11.29 mmol) in dichloromethane (20 mL) was slowly added diethylamino sulfur trifluoride (1.94 mL, 14.68 mmol) at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 18 hours. Upon completion of the reaction, the mixture was carefully poured into pre-cooled saturated sodium bicarbonate solution (300 mL). Extraction was carried out with ethyl acetate (2 x 120 mL) and the organic phases were combined. Subsequently, the organic phase was washed sequentially with saturated sodium bicarbonate solution (80 mL) and brine (2 x 50 mL), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to afford 2-bromo-6-(difluoromethyl)pyridine as a brown oil (2.17 g, 89% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 7.75-7.70 (m, 1H), 7.65-7.60 (m, 2H), 6.60 (t, J = 55.1 Hz, 1H).
References
[1] Patent: WO2017/201468, 2017, A1. Location in patent: Page/Page column 236
[2] Patent: WO2017/80979, 2017, A1. Location in patent: Page/Page column 124; 125
[3] Patent: US2009/253750, 2009, A1. Location in patent: Page/Page column 9
[4] Patent: US2016/221998, 2016, A1. Location in patent: Paragraph 0396; 0397
2-Bromo-6-(difluoromethyl)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 9029 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | sales@anbuchem.com | China | 3000 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39002 | 58 |
| Cochemical Co. Ltd. | +86-029-86115547 +86-17791676824 | sales@cochemical.com | China | 3952 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
View Lastest Price from 2-Bromo-6-(difluoromethyl)pyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-17 | 2-Bromo-6-(difluoromethyl)pyridine
872365-91-8
|
US $2.20-8.80 / kg | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD |
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- 2-Bromo-6-(difluoromethyl)pyridine
872365-91-8
- US $2.20-8.80 / kg
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
