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2-Methyl-4-isothiazolin-3-one hydrochloride

2-Methyl-4-isothiazolin-3-one hydrochloride structure

CAS No.: 26172-54-3

Chemical Name:: 2-Methyl-4-isothiazolin-3-one hydrochloride

Synonyms: 2-METHYL-4-ISOTHIAZOLIN-3-ONE HCL;2-Methylisothiazol-3-one hydrochloride;2-methyl-2H-isothiazol-3-one hydrochloride;3(2H)-Isothiazolone,2-methyl-,hydrochloride;KB-838;MIT·HCL;MIT HYDROCHLORIDE;ISO-THIAZOLINONE(KATHON);N-MethylisothiazoloneHCl;2-Methylisothiazol-3(2H)

CBNumber:: CB9302514

Molecular Formula:: C4H6ClNOS

Molecular Weight:: 151.61

MDL Number:: MFCD06804636

MOL File:: 26172-54-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-06-16 21:18:09

Product description	Number	Pack Size	Price
MIT HCl Ready Made Solution, (125-130 mg MIT HCl/mL in water)	SBR00032	50 mL	$72.9
MIT HCl Ready Made Solution, (125-130 mg MIT HCl/mL in water)	SBR00032	400 mL	$566
2-Methyl-4-isothiazolin-3-one hydrochloride ≥99%	M6045	1g	$166
2-Methyl-4-isothiazolin-3-one hydrochloride ≥99%	M6045	5g	$562
2-Methyl-4-isothiazolin-3-one Hydrochloride (MIT) Asreported	159692	5g	$638
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2-Methyl-4-isothiazolin-3-one hydrochloride Properties

Melting point	165-170°
Density	1.551 at 21℃
vapor pressure	0.777-1Pa at 20-25℃
storage temp.	2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
color	White to Off-White
BRN	3993054
Stability	Hygroscopic
Major Application	microbiology
InChI	InChI=1S/C4H5NOS.ClH/c1-5-4(6)2-3-7-5;/h2-3H,1H3;1H
InChIKey	SJXPQSRCFCPWQQ-UHFFFAOYSA-N
SMILES	O=C1C=CSN1C.Cl
LogP	-0.44 at 20℃ and pH2
Surface tension	71.3mN/m at 1g/L and 20℃
CAS DataBase Reference	26172-54-3(CAS DataBase Reference)
FDA UNII	3G9PNZ5P41
EPA Substance Registry System	3(2H)-Isothiazolone, 2-methyl-, hydrochloride (26172-54-3)
UNSPSC Code	51102829
NACRES	NA.76

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05,GHS06,GHS09
Signal word	Danger
Hazard statements	H301-H314-H317-H410
Precautionary statements	P260-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
PPE	Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Hazard Codes	C
Risk Statements	34-42/43
Safety Statements	26-36/37/39-45
RIDADR	UN 1759 8/PG 2
WGK Germany	3
TSCA	TSCA listed
HazardClass	8, 6.1
HS Code	2934100090
Storage Class	6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials
Hazard Classifications	Acute Tox. 3 Oral Aquatic Acute 1 Aquatic Chronic 1 Eye Dam. 1 Skin Corr. 1A Skin Sens. 1
REACH Registrations	Active
Excepted Quantities	Not Permitted as Excepted Quantity

2-Methyl-4-isothiazolin-3-one hydrochloride price More Price(48)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SBR00032	MIT HCl Ready Made Solution, (125-130 mg MIT HCl/mL in water)		50 mL	$72.9	2026-04-30	Buy
Sigma-Aldrich	SBR00032	MIT HCl Ready Made Solution, (125-130 mg MIT HCl/mL in water)		400 mL	$566	2026-04-30	Buy
Sigma-Aldrich	M6045	2-Methyl-4-isothiazolin-3-one hydrochloride ≥99%	26172-54-3	1g	$166	2026-04-30	Buy
Sigma-Aldrich	M6045	2-Methyl-4-isothiazolin-3-one hydrochloride ≥99%	26172-54-3	5g	$562	2026-04-30	Buy
Usbiological	159692	2-Methyl-4-isothiazolin-3-one Hydrochloride (MIT) Asreported	26172-54-3	5g	$638	2026-06-03	Buy

Product number	Packaging	Price	Buy
SBR00032	50 mL	$72.9	Buy
SBR00032	400 mL	$566	Buy
M6045	1g	$166	Buy
M6045	5g	$562	Buy
159692	5g	$638	Buy

2-Methyl-4-isothiazolin-3-one hydrochloride Chemical Properties,Uses,Production

Uses

2-Methyl-4-isothiazolin-3-one Hydrochloride is an isothiazolinone based biocide and preservative used in personal care products. It is also implicated as an allergen. It is also used for controlling microbial growth in water-containing solution.

Application

Methylisothiazolinone (MIT) has been used:
as a cytotoxic substance to investigate its effect on bronchial epithelial cells (BEAS-2B cells) and its role in apoptotic cell death
to study the effects of tyrosine phosphorylation on focal adhesion kinase (FAK) activity in the development of neural axons and dendrites

General Description

2-Methyl-4-isothiazolin-3-one hydrochloride (MIT) is a derivative of the synthetic isothiazolinone.

Biochem/physiol Actions

2-Methyl-4-isothiazolin-3-one hydrochloride (MIT) is a skin sensitizer known to cause contact dermatitis and allergy. It is extensively used in the cosmetic industry as a preservative. MIT is a neurotoxin and its prolonged exposure may lead to neuronal death and inhibition of neurite outgrowth.

storage

store at 2°C - 8°C,close container well.

2-Methyl-4-isothiazolin-3-one hydrochloride synthesis

Synthesis of 2-Methyl-4-isothiazolin-3-one hydrochloride from Sulfuryl chloride and 3-[(3-AMINO-3-OXOPROPYL)DITHIO]PROPANAMIDE

2-Methyl-4-isothiazolin-3-one hydrochloride Preparation Products And Raw materials

Raw materials

3-[(3-AMINO-3-OXOPROPYL)DITHIO]PROPANAMIDE Sulfuryl chloride

Preparation Products

2-Methyl-4-isothiazolin-3-one hydrochloride Suppliers

Global( 134)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.	+8618950047208	ellena@amitychem.com	China	43414	58
Hebei Chuanghai Biotechnology Co., Ltd	+86-15350571055	Sibel@chuanghaibio.com	China	8738	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21585	55
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19936	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258	factory@coreychem.com	China	29792	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32466	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +86-189 4982 3763	sales@tnjchem.com	China	34563	58
Shanghai UCHEM Inc.	+86-18930848214 +86-021-56762820	sales@myuchem.com	China	8873	58

Supplier	Advantage
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
BOC Sciences	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
SIMAGCHEM CORP	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Shanghai UCHEM Inc.	58

View Lastest Price from 2-Methyl-4-isothiazolin-3-one hydrochloride manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-31	2-Methyl-4-isothiazolin-3-one hydrochloride 26172-54-3	1Kg/Drum	99%	300tons	WUXI HONOR SHINE CHEMICAL CO.,LTD
2026-07-31	2-Methyl-4-isothiazolin-3-one hydrochloride 26172-54-3	1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-06-30	2-Methyl-4-isothiazolin-3-one hydrochloride 26172-54-3	1KG	99%	1000kgs	Shaanxi Dideu New Materials Co. Ltd

2-Methyl-4-isothiazolin-3-one hydrochloride
26172-54-3
$0.00
99%
WUXI HONOR SHINE CHEMICAL CO.,LTD

2-Methyl-4-isothiazolin-3-one hydrochloride
26172-54-3
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

2-Methyl-4-isothiazolin-3-one hydrochloride
26172-54-3
$0.00
99%
Shaanxi Dideu New Materials Co. Ltd

2-Methyl-4-isothiazolin-3-one hydrochloride Spectrum

2-Methyl-4-isothiazolin-3-one hydrochloride(26172-54-3)¹HNMR

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MIT HYDROCHLORIDE 2-METHYL-4-ISOTHIAZOLIN-3-ONE HYDROCHLORIDE N-MethylisothiazoloneHCl ISO-THIAZOLINONE(KATHON) 2-METHYLISOTHIAZOLONE (MIT) HCL, 99+% 2-Methyl-3-isothiazolone Hydrochloride 2-Methyl-4-isothiazolin-3-one hydrochloride,MIT 2-Methyl-4-isothiazolin-3-on hydrochloride 2-Methyl-4-isothiazolin-3-one hydrochloride ((Isothiazolinone)) Methylisothiazolinone hydrochloride 2-METHYL-4-ISOTHIAZOLIN-3-ONE HYDRO& 2-Methylisothiazol-3(2H) 2-methyl-3(2h)-isothiazolonhydrochloride 2-Methylisothiazol-3(2H)-one hydrochloride MIT·HCL 2-Methyl-3-isothiazolone Hydrochloride Discontinued See M314985 3(2H)-Isothiazolone, 2-methyl-, hydrochloride (1:1) Methylisothiazolinone HCl N-Methylisothiazolin-3-one KB-838 2-Methylisothiazol-3-one hydrochloride 2-methyl-2H-isothiazol-3-one hydrochloride 2-METHYL-4-ISOTHIAZOLIN-3-ONE HCL 3(2H)-Isothiazolone,2-methyl-,hydrochloride 26172-54-3 C4H5NOSClH C4H5NOSHCl C4H6ClNOSC4H5NOSHCl BioChemical Antibiotics Antibiotics A to Z Antibiotics G-M Amines Heterocycles Sulfur & Selenium Compounds